1AON,1AON,1IOK,1WF4,1SX4,1SX3


Conserved Protein Domain Family
GroEL

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cd03344: GroEL 
Click on image for an interactive view with Cn3D
GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found in eubacteria (GroEL) and in organelles of eubacterial descent (hsp60 and RBP). With the aid of cochaperonin GroES, GroEL encapsulates non-native substrate proteins inside the cavity of the GroEL-ES complex and promotes folding by using energy derived from ATP hydrolysis.
Statistics
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PSSM-Id: 239460
Aligned: 99 rows
Threshold Bit Score: 555.144
Created: 6-Jan-2006
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 11 residues -Click on image for an interactive view with Cn3D
Feature 1:ATP/Mg binding site [chemical binding site]
Evidence:
  • Structure:1AON_G; E.coli GroEL/GroES chaperonin
  • Citation:PMID 9285585

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                ###                                                  
1AON_H      3 KDVKFGNDARVKMLRGVNVLADAVKVTLGPKGRNVVLDKsfGAPTITKDGVSVAREIEledkfeNMGAQMVKEVASKAND 82  Escherichia coli
AAM63618   49 KEIAFDQHSRAALQAGIDKLADCVGLTLGPRGRNVVLDEf-GSPKVVNDGVTIARAIElpnameNAGAALIREVASKTND 127 thale cress
CAC27068   46 KKVVFGEESRKALVNGINSVADAVKITLGPKGRNVVLERsfGSPQVINDGVTIARDIElenplyNTGARLLQEVASKTDL 125 Guillardia theta
Q42694     37 KEIVFDQESRRRLQAGINKVADAVGVTLGPRGRNVVLEQkfGVPQVINDGVSIRRAIElkdpveNAGAQLIKEVAGRTND 116 Chlamydomonas rein...
EAN30941  117 KEIVLSDDCRNSLLNGILKVADTVRVTLGPRGRNILLEKefGSPIIVNDGVTIARNIElsdrkmNAGAKLIQEIASSSDD 196 Theileria parva
NP_197383  36 KRILYGKDSREKLQAGIDKLADAVSITLGPRGRNVVLAEk-DTIKVINDGVTIAKSIElpdtieNAGATLIQEVAIKMNE 114 thale cress
BAD04206    3 KKILYGKEARKALLQGVDAIANTVKVTLGPKGRNVILEKayDSPAIVNDGVSIAKEIElknpyqNMGAKLVYEVASKTND 82  Onion yellows phyt...
AAP56827    4 KELTFEQQARAKLLEGINKLAKAVKITAGPKGRNALIEKkyGAPLIVNDGVTIAREIElkdpveNMGAKLIAEAAISTND 83  Mycoplasma gallise...
NP_701671  70 KDIIYGNECRNELLKGILTVSDVVKLTLGPRGRNVLLEKeyGSPLIINDGVTIAKNISlkdrkkNNGVKLMQESTNISND 149 Plasmodium falcipa...
ABA27204    4 KNICYRDVIIKQIKKGLQDTTNILSLTLGPRGKNIVLWDktSKPQIINDGTSIINKINnqnfveHIGQFLVKDVIFNVND 83  Bigelowiella natans
Feature 1        #   #                                                          #             
1AON_H     83 AAGDGTTTATVLAQAIITEGLKAVAAGMNPMDLKRGIDKAVTAAVEELKALSVPCsdSKAIAQVGTISANsDETVGKLIA 162 Escherichia coli
AAM63618  128 SAGDGTTTASILAREIIKHGLLSVTSGANPVSLKRGIDKTVQGLIEELQKKARPVkdRDDIRAVASISAGnDDLIGSMIA 207 thale cress
CAC27068  126 KAGDGTTTSTVLTQSIVNQGIKAVSSGVNPLALKRGIEKTCRFLIEEIKKKSKPCngIEDIRNIATIASGgNDEIGRIIS 205 Guillardia theta
Q42694    117 AAGDGTTTASVLAREMIHYGLQSVTAGANPIAVKRGLDKTAEYLVAKLKEHAKPVkgRDDIKNVASISAGnDNAIGEMIA 196 Chlamydomonas rein...
EAN30941  197 RAGDGTTSTAILAAEIASKGVQYVNEGHNSIPLQKGIQKAGKLIIEEIKQLSKPVagYNDLLNVGTVATSgNVVMGQVIA 276 Theileria parva
NP_197383 115 SAGDGTTTAIILAREMIKAGSLAIAFGANAVSVKNGMNKTVKELVRVLQMKSIPVqgKNDIKAVASISAGnDEFVGNLIA 194 thale cress
BAD04206   83 KAGDGTTTATVLAQSMIHRGFDAIDAGANPVLVKEGIELAALTVAKKLLAKSKKVdaQEDIQNVAAVSSG-SQEIGKIIA 161 Onion yellows phyt...
AAP56827   84 IAGDGTTTATILTHEIVNKAIEAINNGTNPVNLRIGIENAAKLVSEYLTSVSKPIksIDEITQVGAISSG-SKFIGELIA 162 Mycoplasma gallise...
NP_701671 150 KAGDGTSSTALMTATITKKGIEQVNRNHNPIPIQRGIQLASKMIIEKIKSLSTPIktYKDILNIATIASNnDVHMGQIIA 229 Plasmodium falcipa...
ABA27204   84 SVGDGTSTTGILTGNVLSRGLSLIHSGYTPYFFSNGIFKCTNILLNKLYKISWPLnnNKDILNIATNSSGgDKLLGKLIV 163 Bigelowiella natans
Feature 1                                                                                     
1AON_H    163 EAMDKVGKEGVITVEDGtglQDELDVVeGMQFDRGYLSPYFINKPetGAVELESPFILLADKKISNirEMLPVLEAVAKA 242 Escherichia coli
AAM63618  208 DAIDKVGPDGVLSIESSssfETTVEVEeGMEIDRGYISPQFVTNPekLLAEFENARVLITDQKITAikDIIPILEKTTQL 287 thale cress
CAC27068  206 SAFEKVGQNGSTTVEESqslQDEVDFTeGMELDRGYISPYFVKDMerQIAEFINPRILVTDKKISSvqELVPILEMIVKH 285 Guillardia theta
Q42694    197 DALDKVGSNGVLSIETSnstETVVEVQeGMEIDRGYISPQFVTNQerLLVEYDNCRVLVTDQKIDAirDIIPILEQVTRL 276 Chlamydomonas rein...
EAN30941  277 KAFDKLGGNAAVVLEDNpalEDELDFTeGYTFDRGFANPYFLLGEekESIEWSNPHILVYDGKIENaqSVLNILEFAAKN 356 Theileria parva
NP_197383 195 ETVEKIGPDGVISIESSstsETSVIVEeGMKFDKGYMSPHFITNQekSTVEFDKAKILVTDQKITSakELVPLLEKTSQL 274 thale cress
BAD04206  162 QAMQKVGKDGVINVDESkgfETELEVVeGLQYDKGYASPYFVSDResMTVQLENALVLVTDHKISTvqEIVPILEEVVKA 241 Onion yellows phyt...
AAP56827  163 KAMDIVGPSGVISIDDAksfDTTLDTTdGLEFKGGYSSPYMVTDSekMLSELANPKILVSLNKINTvkEILPLLEASVES 242 Mycoplasma gallise...
NP_701671 230 NAYDKLGKNAAIILDDNadiNDKLEFTeGYNFDRGIINPYLLYNEnkDYIEYSNVSTLITDQNIDNiqSILPILEIFAKN 309 Plasmodium falcipa...
ABA27204  164 NAYKRVGTDGLISIETSdknDTSLIVYgGLQIDRGYVSHKFINNFknSTCEYNDSAILVTDLPIDSikQAAAIMQSILQI 243 Bigelowiella natans
Feature 1                                                                                     
1AON_H    243 gkplLIIAEDVEGEALATLVVNTmrgiVKVAAVKapgfGDRRKAMLQDIATLTGGTVIseeigmelEKATLEDLGQAKRV 322 Escherichia coli
AAM63618  288 raplLIIAEDVTGEALATLVVNKlrgvLNVVAVKapgfGERRKAMLQDIAILTGAEYLamdmsllvENATIDQLGIARKV 367 thale cress
CAC27068  286 keplVIIAEDVTGEALSTLVVNKmrgvLDVCAIKspgfGERKKAYLEDISVLTGATFIaeevgltlDKIKIEQLGKANRV 365 Guillardia theta
Q42694    277 naplLIIAEDVSGEALATLVVNKlrgvLNVCAIKapgfGERRKSLLQDIAIVTGAEFIakdlgmkvEQAVVEQLGVARKV 356 Chlamydomonas rein...
EAN30941  357 kvnlLIIAEDYGTDAMQTFIINKmrgmLKIAAVKspsfGERRKDYLQDIAVATGATFVssdvgvdlNDITPEMLGHAKNV 436 Theileria parva
NP_197383 275 svplLIIAEDISAEVLEILVVNKkqglINVAVVKcpgmLDGKKALLQDIALMTGADYLsgdlgmslMGATSDQLGVSRRV 354 thale cress
BAD04206  242 srplLIVAEAVENEVLGVLVANKlrgtFNVVVTNapgfGDNQKEMLQDIAVLTKANFVskelnmklADLKMDDLGNINKA 321 Onion yellows phyt...
AAP56827  243 saplLIVASDIAEDVVTALAINKlrgtLNVVSVKcaefGEAQKNTLEDLAISVNTILVdsaagiefKDLELNKLGSAEKV 322 Mycoplasma gallise...
NP_701671 310 kqplCIIADDFSNEVLQTLIINKl--kGAIKVVHlc-iVTNSKYISADVGLDLNNLHNnms---sfDNNYLSLLGSANTL 383 Plasmodium falcipa...
ABA27204  244 dkplLIISDTISKKCLNAFLVNNkeknIKICAVKipsfGSYRKSILQDISIATGASFYssdsgmklKNLKPEDFGSLRKC 323 Bigelowiella natans
Feature 1                                                                               #     
1AON_H    323 VINKDTTTIIDGvgeeaaIQGRVAQIRQQIEEAtsdydREKLQERVAKlagGVAVIKVGAATEVEMKEKKARVEDALHAT 402 Escherichia coli
AAM63618  368 TISKDSTTLIADaaskdeLQARIAQLKKELFETdsvydSEKLAERIAKlsgGVAVIKVGAATETELEDRKLRIEDAKNAT 447 thale cress
CAC27068  366 VVAKEACTIISDstnqesVNKRIELIKKQIANTdsdfdREKGEERIARlggGIARIKVGAATETELKDKKLRYEDSINST 445 Guillardia theta
Q42694    357 TVANNTTTLIADaaskdeIEMRIAQLKKELAETdsvydTEKLSERIAKlsgGVAVIKVGAATEAELEDRKLRIEDAKNAT 436 Chlamydomonas rein...
EAN30941  437 VIKKDRTSIVTNpevlpqIKNRINSLIREKEMCtssydKTKLSERIAAlsgGIARIRIGAATETELKEKRLRYEDAINAV 516 Theileria parva
NP_197383 355 VITANSTTIVADastkpeIQARIAQMKKDLAETdnsylSKKIAERIAKltgGVAVIKVGGHTETELEDRKLRIEDAKNAT 434 thale cress
BAD04206  322 IIKKDNTTLISNsks-peLEKRIQVLKTQIKNAtsdyeTKNLQERLAKlsgGVALIKVGAATDTELKDKKLRIEDALNAT 400 Onion yellows phyt...
AAP56827  323 IISKDKTTVINGachkdvLAKYLNNLKAKSANLtskydKERITKRIANlsnGVAVIHVGGATEVAQKELKLRIEDALNST 402 Mycoplasma gallise...
NP_701671 384 IVKKDRTSLITKeeykkeIDERINVLKKEYEETtskydKEKLNERIAAlsgGIAKILIGGNSETEQKERKFKYEDATNAV 463 Plasmodium falcipa...
ABA27204  324 IVSENNCTLISKnrfknqIKSRIDYLEKLLSSTdstfeTNLLSERIAKlsgGIAVIRVGAPTELELIDKKLRLEDAKNAT 403 Bigelowiella natans
Feature 1                #                                                                    
1AON_H    403 RAAVEEGVVAGGGVALIRVASKLADLrg--------------------------------------------qnEDQNVG 438 Escherichia coli
AAM63618  448 FAAIEEGIVPGGGAALVHLSTVIPAIket------------------------------------------fedADERLG 485 thale cress
CAC27068  446 KAAIEMGILPGGGSTLISLIRLIPSIqek------------------------------------------ledEEEKLG 483 Guillardia theta
Q42694    437 FAAVEEGIVPGGGAALLHLSELVPAFket------------------------------------------ltdAEEKLG 474 Chlamydomonas rein...
EAN30941  517 RAAMETGYVPGGGVTYLQMQNPEFTRklmeyikntvdkelseltpldtstdagatpvpsefdkldsqeemeseiELQQAG 596 Theileria parva
NP_197383 435 FAAMREGIVPGGGATYIHLLDEIPRIkknl-----------------------------------------medSYEQIG 473 thale cress
BAD04206  401 KAAITEGIVVGGGKALVEVYQELKDTlvs-------------------------------------------dnKEVQQG 437 Onion yellows phyt...
AAP56827  403 KAAVEEGIVAGGGIALMNAIEVLKQVke--------------------------------------------snPEIALG 438 Mycoplasma gallise...
NP_701671 464 KSAIDIGYVPGGGVTYLEIIKSNFIQeihkkieedlqissnn----------------dekkylelignlesemELQKMG 527 Plasmodium falcipa...
ABA27204  404 FSAVTQGVVTGSAVSLVHLSNFLKYFmal------------------------------------------sscMEESLG 441 Bigelowiella natans
Feature 1                   #                                        # #                      
1AON_H    439 IKVALRAMEAPLRQIVLNCGEEPSVVANTVKGGdg--nYGYNAateeyGNMIDMGILDPTKVTRSALQYAASVAGLMITT 516 Escherichia coli
AAM63618  486 ADIVQKALLSPAALIAQNAGVEGEVVVEKIMFSdw--eNGYNAmtdtyENLFEAGVIDPAKVTRCALQNAASVAGMVLTT 563 thale cress
CAC27068  484 ASILAKAMEAPILQIAKNSGQEGEVVLDKCKKMef--gMGYNAatnsyENLLESGVVDPAKVTCWALENSCSIASMVLTT 561 Guillardia theta
Q42694    475 ADIVMKSLRAPCRLIADNAGVEGEVIVQRLLGKpf--eVGYNAmidkvENLLDAGVIDPAKVTRNGLLNSVSIAGIMLTT 552 Chlamydomonas rein...
EAN30941  597 AKIVLDSMSIITKQIANNAGVDGEKVVERILKSgkpfgYGWNAktnsyGDMIKQGVIDPSKVVMSAVEHSTSVAGLLLTT 676 Theileria parva
NP_197383 474 ADIVAMALTAPAMAIATNAGVDGSVVVQKTRELew--rSGYNAmsgkyEDLLNAGIADPCRVSRFALQNAVSVAGIILTT 551 thale cress
BAD04206  438 IDVVVQSLLVPTYQIAYNAGFSGKDVVKQQLLQpl--nFGFNAkegkyVCLLKEGIIDPTKVTRQAVLNAASISALMITT 515 Onion yellows phyt...
AAP56827  439 YEIVRSSLTAPARQIIENAGQNSSKIINNIINSkq-lgYGYNAetnefVNMINNGIIDPTKVTKTALEKACSVAALLITT 517 Mycoplasma gallise...
NP_701671 528 ANIVVSSLDVITKQIADNAGVNGDNVVKIILNSkdkygFGYDVntnkfVNMVEKGIIDSTNVIISVIKNSCSIASMVLTT 607 Plasmodium falcipa...
ABA27204  442 MQLLRKSIVVPNRNIILNSDEDGYLMEKKIVNYpf--eIGYDAeykclTNLVGEGVVDPSLLLYNSLISLCKISSVLMHT 519 Bigelowiella natans
Feature 1           
1AON_H    517 ECMVTD 522 Escherichia coli
AAM63618  564 QAIVVD 569 thale cress
CAC27068  562 EALVVE 567 Guillardia theta
Q42694    553 QAVMVE 558 Chlamydomonas reinhardtii
EAN30941  677 EGMMVE 682 Theileria parva
NP_197383 552 QAVLVE 557 thale cress
BAD04206  516 EAAVVS 521 Onion yellows phytoplasma OY-M
AAP56827  518 EVAIND 523 Mycoplasma gallisepticum R
NP_701671 608 ECMMVD 613 Plasmodium falciparum 3D7
ABA27204  520 QAVISK 525 Bigelowiella natans

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