3AQG,3APA


Conserved Protein Domain Family
Jacalin_ZG16_like
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cd09611: Jacalin_ZG16_like 
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Jacalin-like lectin domain of the zymogen granule protein 16 and related proteins
ZG16p is a conserved secreted vertebrate protein with tissue-specific expression profiles, which might play a role in glycoprotein secretion, perhaps as a linker protein that participates in the formation and/or transport of the zymogen granule. Its paralog ZG16b (PAUF) has been associated with roles in gene regulation and cancer. This domain family also contains mammalian proteins labelled as prostatic spermine-binding protein (SBP) and salivary-gland specific secreted proteins.
Links
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Statistics
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PSSM-Id: 187707
Aligned: 12 rows
Threshold Bit Score: 128.979
Created: 12-Nov-2010
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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putative sugar
Conserved site includes 16 residues -Click on image for an interactive view with Cn3D
Feature 1:putative sugar binding site [chemical binding site]
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1            ##                        ##              # #                      ##        
3AQG_A          7 GPGGGKYFSTted----ydhEITGLRVSVGLl-------------LVKSVQVKLGD-----SWDVKLGALGG--NTQEVT 62   human
3APA_A         13 GSGGGKRFSHsgnq---ldgPITALRVRVNTy-------------YIVGLQVRYGK-----VWSDYVGGRNG--DLEEIF 69   human
P15501         22 GNAAGKYFYVqged--qgqlKGMRIFLSVFK--------------FIKGFQLQFGS-----NWTDVYGTRSD--NFIDFL 78   house mouse
P08723         22 GNNVGTYFYVage----ehgQLRGIRIFLTVi------------dLIKGIQLRFGG-----NWSDVYGSRSL--KYKEFL 78   Norway rat
AAA16140       23 GSETGKHFCIvap----egePVTGIWASLKNn-------------ILSSIRLKFGN-----NWSQEYGSSGR--AEIEVK 78   Norway rat
O60844         31 GSGGGKRFSHsgnq---ldgPITALRVRVNTy-------------YIVGLQVRYGK-----VWSDYVGGRNG--DLEEIF 87   human
Q96DA0         57 GPGGGKYFSTted----ydhEITGLRVSVGLl-------------LVKSVQVKLGD-----SWDVKLGALGG--NTQEVT 112  human
ACD54718       21 GFNTDNAFNDideigydavyTPRLIIIKAGS--------------SIDAIQINYGAasgiiRQASQHGGTGG--SECKFS 84   Adineta vaga
ACM09774       30 GQGGGTPFASyg------egRITGVRVWETNnnyyyyyyyynsnaYISGFQLRYGS-----TWSPVFGREGG--EKQEME 96   Atlantic salmon
YP_003086222   35 GPYSHNPFTGvd------gqPITKIIAHSNNa------------sTLCGLEVFYDG-----RSSGLKGARGT--NSSSIV 89   Dyadobacter f...
XP_002943205   33 GSGGGTAFSFsseq---vygPITGLRVRENPs-------------HVIGLQFRYGD-----TWGTYYGYTSG--PILEIL 89   western clawe...
XP_002950250  999 ADDEGEFFDDlsyas-wgknVITRIVHKAGE--------------YVESIQVVYGS-----MPARVHGGDSDgeLHDHRV 1058 Volvox carter...

Feature 1                       ##  # #                  #                                #   # # 
3AQG_A         63 LQpGEYITKVFVAFQA--FLRGMVMYTSK-DRYFYFGKLD----GQISSAYPsq------eGQVLVGIYGQYQl-LGIKS 128  human
3APA_A         70 LHpGESVIQVSGKYKW--YLKKLVFVTDK-GRYLSFGKDS----GTSFNAVPlh------pNTVLRFISGRSG--SLIDA 134  human
P15501         79 LEdGEHVIKVEGSAVI--CLTSLTFTTNK-GRVATFGVRR----GRYFSDTGg-------sDKHLVTVNGMHApgLCVRG 144  house mouse
P08723         79 LEdGEHVTQVSGTRKL--CLTSLSFTTNK-GRVVTFGVRR----GLSFNESGg-------sDKYLVTVNGLYApgLCLNG 144  Norway rat
AAA16140       79 LNpDETVLGFSGSFYI--FMHQIIITTSQ-PRELIIGPLT----GRYVYTSYpe-----npNHVFRGICGYYVt-GGLKG 145  Norway rat
O60844         88 LHpGESVIQVSGKYKW--YLKKLVFVTDK-GRYLSFGKDS----GTSFNAVPlh------pNTVLRFISGRSG--SLIDA 152  human
Q96DA0        113 LQpGEYITKVFVAFQA--FLRGMVMYTSK-DRYFYFGKLD----GQISSAYPsq------eGQVLVGIYGQYQl-LGIKS 178  human
ACD54718       85 IDaDERIVKVEGSVGT--AVSGLMFTTNKgRKSPRCGAAAs---NKDFVEQYp--------GYVLSYISGRSG--NYLNQ 149  Adineta vaga
ACM09774       97 LFnDESIVEVSGKYNPvdYICKLVLTTNT-GRTLSAGQPS----QVSFNFYPan------mGNELRLLSGRFNg-AGITS 164  Atlantic salmon
YP_003086222   90 LEeGEYITSVYGYLRN--IIEGVWFTTQK-GNTVGAGNRAphyaRHLFCADIad-----sfNPKLAKISGSYNg-DTIEH 160  Dyadobacter f...
XP_002943205   90 LRpGESITQVSGKTAA--YVNELIFVTNH-GRIFRFGQPS----GNCFNDFPly------sNTVLRYVSGRYS--SVIHS 154  western clawe...
XP_002950250 1059 EG-GEFINSAVVYYDEn-AVHGMDLGTNV-GRQIVIGSLRd--gVRRAVATPcpadeqhegRYRLIALAGTAD--RYLRS 1131 Volvox carter...

Feature 1               
3AQG_A        129 IGFEWN 134  human
3APA_A        135 IGLHWD 140  human
P15501        145 IGFKWG 150  house mouse
P08723        145 MGFKWK 150  Norway rat
AAA16140      146 MRYLWG 151  Norway rat
O60844        153 IGLHWD 158  human
Q96DA0        179 IGFEWN 184  human
ACD54718      150 IRFYWT 155  Adineta vaga
ACM09774      165 IGAHWG 170  Atlantic salmon
YP_003086222  161 LTFHWE 166  Dyadobacter fermentans DSM 18053
XP_002943205  155 IGFHWG 160  western clawed frog
XP_002950250 1132 VTLLWS 1137 Volvox carteri f. nagariensis

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