2NYG


Conserved Protein Domain Family
Antibiotic_NAT

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pfam02522: Antibiotic_NAT 
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Aminoglycoside 3-N-acetyltransferase
This family consists of bacterial aminoglycoside 3-N-acetyltransferases EC:2.3.1.81, these catalyze the reaction: Acetyl-Co + a 2-deoxystreptamine antibiotic <=> CoA + N3'-acetyl-2-deoxystreptamine antibiotic. The enzyme can use a range of antibiotics with 2-deoxystreptamine rings as acceptor for its acetyltransferase activity, this inactivates and confers resistance to gentamicin, kanamycin, tobramycin, neomycin and apramycin amongst others.
Statistics
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PSSM-Id: 426815
Aligned: 108 rows
Threshold Bit Score: 137.742
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2NYG_E           34 LVHSSLSSIG-WVNGGA-----VAVIQALIDVVTEEG--TIVMPSQS------VelsDPKEWGNPPVPeewWDIIRESM- 98  Bacillus sub...
CCE24397         24 MVHSSWLPLN-GFKGRP-----VDMVSALKDVAGQSG--ILIMPTLT------------------------YQNKSS--- 68 
tigr:AHA_4186    21 MVHSDAMVVA-QFAGMGnaagiAAFWTCLEQWLG--G--HLLVPTFS------------------------YSPMAD--- 68 
CCB85723         25 LVHSDLLRLGiPEQAKNreailNFYLNAFQSILGKKG--TIAVPAYF--------------------------------- 69 
CDD74483         39 lIHTDL-----SFGLPTrelkrKELVEVLYDAICELGvkTLIFPTFT------------------------FSYGNR--- 86 
UCNUF:IALB_1029  19 IIHSSFKGISaSFPVSP-----DAVINSLKDIVTSNG--SIIFPTFT------------------------YFFKKSAGd 67 
Q97H17           33 FLHSDITVFG-KLILTDrkkffNDILSSVKDVVGKKG--VVIMPTFS------------------------YSFCNG--- 82  Clostridium ...
jgi:Mmc1_1157    61 LLHSSMDQLVaHVPELKp----FTLIQLLKDKLGPQG--TLLMPAYP---------------------------FRGAQ- 106
Q7MXQ7           56 IVTSGFGYLG-AEGYSP-----EDVVCLLQSLVTDEG--LIMMPYYP------------------------------PKn 97  Porphyromona...
WP_015234212     31 iAHASLRAFG-FLEGGA-----PTMLRALR---ARSA--TLVMPSFSyytlvwPeeqRQPDWAKPAPP---------PG- 89  Deinococcus ...
2NYG_E           99 -PAY-------NSNYT-PTtrG--MGQIVELFRSYPEVKRSNHPNYSFVAWGKHKNKI-LNQHPLE-FGLGEQSPLGKLY 165 Bacillus sub...
CCE24397         69 -RDFllsstpmDVTRS-PS--M--MGLLSEVFRRGKDVTRSLSPTHPLAVWGDKRDEFvQGHESCL-VPFGVGSPFEKLL 141
tigr:AHA_4186    69 -ECF-------DPAQTpSK-----VGLMTELFRQREGVVRTRDPVFSMAISGPQGPALvERECH---DCFGQESPFGWLA 132
CCB85723         70 -YEYarhgipfDTEYS-PV--SksLGAFSAHICTLQGKVRSGNPLQSIAAIGPHAEYI-SGGNSL--SGYGINSPWHRLH 142
CDD74483         87 -EDF-------DVKNTkCK-----MGMLNEYVRKMPESVRSKDPLMSVCVIGENKELAkVSGN----KSLGEGSFFDRFH 149
UCNUF:IALB_1029  68 yEIF-------DREISkSK-----VGLLSETFRLSKGVIRTSSPTHSFALWGKIKNDI-DETNSPE-SPLGKESVLEWLT 133
Q97H17           83 -EVF-------DVKKTkGT-----VGALNEFFRKSEDTVRTVQPIFSCSVWGERKNEF----LNISlDSFGQDSIFDKLF 145 Clostridium ...
jgi:Mmc1_1157   107 -ADYarqaapfNPART-PS--R--SGLLTEMLRRDRTAIRSWHPTHAMVGWGQHAEAL-LADHHKG-HPFGPTSPFQKLA 178
Q7MXQ7           98 sHEWasegevfDMNHT-KS--G--MGVLTNVFAQAAGVYMSVHPTKAVCVWGKDAEQI-VQGHECTeTPYAHNSPYGKVL 171 Porphyromona...
WP_015234212     90 -PAY-------GRFSRvSS--D--IGRVPQTLADDATTLRSFHPALSFVALGERAEEV-LDAQSLE-SPYG---PIGKLY 152 Deinococcus ...
2NYG_E          166 IR-ESYVLLLGADFDSS-TCFHLAEYRI-----PYQKI--INRGA-PII-V-EGKr-----VWKEYKELEfre--elFQE 226 Bacillus sub...
CCE24397        142 QC-NGKILTIDAPFATI-TFTHYLEDRIas-flPFPLYdpSPMTG-QVIdYdKKLlevq-----vnviSEiansarcEQR 212
tigr:AHA_4186   133 EQ-DGWLLGLGCHPDRI-TFTHYVEQRLav------sYryHKMFAgQVRvDgRVRewq-adYYVRDLSlas---eidLSR 200
CCB85723        143 SL-NAKMVFIGIGMETM-TYVHHIEQEVgvphlYFKVYpyPVTRGdnpip-------gypvSAVRYLNygi---eynLKP 210
CDD74483        150 HTkNTRIMFFGAQLPQChTQMHYVEEKLrv------pYryDMKFEgNIIdEnGVStpdahiLYVKYRDvlp----cvpPS 219
UCNUF:IALB_1029 134 HQqNSFVLILGTDFSSL-SYGHYLEVAAkvpwfDFSPWdyLNVLPiGVStNgEQKl------------KEipgcakgFVK 200
Q97H17          146 KS-NGKLLFLGADFHSC-TYLHYIEQSFgi------pYryLKIFK-GKIkDgENEylseckFYVRYLDknv---vleTER 213 Clostridium ...
jgi:Mmc1_1157   179 QQ-QGEVMGLGVGLESY-SLLHVPETMVp---eLQRAVyyDQPYPmQIVvQaEQNitcm------vplLRmggayrrVER 247
Q7MXQ7          172 QL-GSKSIGLGVG---NaPMFHVFEDTWd---sPRSRYyqEQPYLlNVIlKdGSKte--vsTMVHRADmvds--atpISE 240 Porphyromona...
WP_015234212    153 DL-DGVAVLLGVDHRSN-TTIHYGEYWAg---vP------LLDRY-VVV---NGEv-----RRTSFPNCSa-----dFGR 207 Deinococcus ...
2NYG_E          227 VGQAFEAEhNMk-vGKVGSANCRLFSLTEAVDFAEKWFI 264 Bacillus subtilis
CCE24397        213 LVDRLNRC-GAmkhKRIGNTHLMLIECKTMADCVDDMVk 250
tigr:AHA_4186   201 LVALLQER-GAwrqTLCQRVPVWAVSCRDFILAASELLA 238
CCB85723        211 FESLLLQR-GLarsISVGKGNILSVSTEDTFQEGVKYLE 248
CDD74483        220 FEQELINE-GLflkKKVGNSSIACFTEQAAYDKEVEWLT 257
UCNUF:IALB_1029 201 FEKYLLDK-NLinkQEYKSLSSYFINIQLLFNEGMKYFQ 238
Q97H17          214 LKKHLLEE-KImseTLVGDGSILSVDARKLYDEVFKMLK 251 Clostridium acetobutylicum
jgi:Mmc1_1157   248 VARILRRE-QIlweQHVHGLRLSRMSAAPFIQRALTLQQ 285
Q7MXQ7          241 YIRNLNAPty--rrIKFGKSFVWIADNTELSEITKRRFE 277 Porphyromonas gingivalis
WP_015234212    208 IAPHVRGEs-----VTLGRGRITAFRVRELVDGARRLLA 241 Deinococcus peraridilitoris
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