3SO6


Conserved Protein Domain Family
PTB_LDLRAP-mammal-like

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cd13159: PTB_LDLRAP-mammal-like 
Click on image for an interactive view with Cn3D
Low Density Lipoprotein Receptor Adaptor Protein 1 (LDLRAP1) in mammals and similar proteins Phosphotyrosine-binding (PTB) PH-like fold
The null mutations in the LDL receptor adaptor protein 1 (LDLRAP1) gene, which serves as an adaptor for LDLR endocytosis in the liver, causes autosomal recessive hypercholesterolemia (ARH). LDLRAP1 contains a single PTB domain. PTB domains have a common PH-like fold and are found in various eukaryotic signaling molecules. This domain was initially shown to binds peptides with a NPXY motif with differing requirements for phosphorylation of the tyrosine, although more recent studies have found that some types of PTB domains can bind to peptides lack tyrosine residues altogether. In contrast to SH2 domains, which recognize phosphotyrosine and adjacent carboxy-terminal residues, PTB-domain binding specificity is conferred by residues amino-terminal to the phosphotyrosine. PTB domains are classified into three groups: phosphotyrosine-dependent Shc-like, phosphotyrosine-dependent IRS-like, and phosphotyrosine-independent Dab-like PTB domains. This cd contains mammals, insects, and sponges.
Statistics
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PSSM-Id: 269981
Aligned: 19 rows
Threshold Bit Score: 154.412
Created: 10-Feb-2012
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
peptide bindingputative
Conserved site includes 16 residues -Click on image for an interactive view with Cn3D
Feature 1:peptide binding site [polypeptide binding site]
Evidence:
  • Structure:3S06; ARH PTB domain binds LDLR tail, contacts at 4A

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                      ##
3SO6_A         2 EGMVFSLKYLGMtlverp-----kgeelSAAAVKRIVATAKasgk---klqKVTLKVSPRGIILTDSlts-qlIENVSIY 72  Norway rat
XP_002414873  37 EGITFYAKYLGStlveep-----sgdkaTADAIRAIIGMAKasgk---klaKVALTVSPKGISTRDVatg-elQLDVSIY 107 black-legged tick
XP_967390     41 DVITFKLKYLGStvvekl-----vgdsiNTEAVKNIIKVTKasrk---klqRVNIAISLKGIAVTDLeg--ndILKISIY 110 red flour beetle
EFN90151      35 SEARFTLKYLGStlvetp-----sseeaTAEAIKTVITMAKasgk---klqRVSLAVSLRGIRMTDLate-edQLQVSIY 105 Harpegnathos sa...
XP_002424308  28 DEVMFRAKYLGStlveka-----sseetTAEAIKTILSMSKvggk---klqRVIVFLGLQGIKVVNIpte-eiHLDISIY 98  human body louse
ABA61315      38 EGMTFYLKYLGStlveeisdgesygdgiSTKAIQRVISMEKssgk---kwrKVALNVSPRGIKMCDMisn-emLLDVCIY 113 Doryteuthis pea...
ADD18958      61 IFQTYDIKYLGCtpietk-----rsekvTSEAIKTVIANAKaggrkiksqkRVKLNVSQDGIQVLDHatd-etLMHFSIY 134 Glossina morsit...
NP_001155918  41 DQTTFEVKYLGNtpvds-------tagaIVEAVKTILVMAKaskr---kpqNVTVTLNGQGIKVIETsdekktVLETPIE 110 pea aphid
BAM18177      39 AGEQGEVRYAGVvpvera-----asapaTALAVRSALHTIKssnk---klqRVTLDISAKGILVIDVdsq-qnVLSVSIY 109 Papilio xuthus
XP_002065032  43 LFATHQLKYMGYthie---------atrSEKLVANAIKTLKsnrtkgqaqrNVTINVLPTEVEIIDIvtq-eiILNLSIY 112 Drosophila will...
Feature 1        #######            #          #             #  ##  #  # 
3SO6_A        73 RISYCTADkmhDKVFAYIAQSq----qNESLECHAFLCTKRKVAQAVTLTVAQAFK 124 Norway rat
XP_002414873 108 RISFCSADasfDRVVAFIATHs-----NEVMECHAFLTAKRKVAQAAALTISQAFQ 158 black-legged tick
XP_967390    111 RISNCSTDpthRQVFSFVSTDa-----HETMECHAFICSKRKMAETVTLAVAHAFS 161 red flour beetle
EFN90151     106 RISYCSADathDHVFAFIATNl-----NETMECHAFLCPKRKMAQTVTLTVAQAFN 156 Harpegnathos saltator
XP_002424308  99 SISYCSADashSQVFAFIATNd-----NNTMECHAFLCPKRKTAQVMSLTLAKVFR 149 human body louse
ABA61315     114 RISFCTADrnhERVFAFIARNt----iNETMECYVYVCAKRKIAQAVTLTASQAFH 165 Doryteuthis pealeii
ADD18958     135 KISYCSVDashDHAFSFVGSEpdplsdQEKMSCHVFLCPKRKIAHEITLLVARCFE 190 Glossina morsitans morsitans
NP_001155918 111 RVSHCFTDsahSNVFAFVTASg-----LTMSECHAFMCAKRKMAQNMSVTIGQSIS 161 pea aphid
BAM18177     110 RISYCSADaanARVFAVVEGKkes-gsEENHVVHVFVCARAKQARALALSLAHAFN 164 Papilio xuthus
XP_002065032 113 DVSYCTAQ---HEFFALVGSEkcpsldQEKLLCYVFQCPKRKVAKQITLAVARSFG 165 Drosophila willistoni

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