3PGB


Conserved Protein Domain Family
Cu_amine_oxid

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pfam01179: Cu_amine_oxid 
Copper amine oxidase, enzyme domain
Copper amine oxidases are a ubiquitous and novel group of quinoenzymes that catalyze the oxidative deamination of primary amines to the corresponding aldehydes, with concomitant reduction of molecular oxygen to hydrogen peroxide. The enzymes are dimers of identical 70-90 kDa subunits, each of which contains a single copper ion and a covalently bound cofactor formed by the post-translational modification of a tyrosine side chain to 2,4,5-trihydroxyphenylalanine quinone (TPQ). This family corresponds to the catalytic domain of the enzyme.
Statistics
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PSSM-Id: 460100
Aligned: 299 rows
Threshold Bit Score: 344.825
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3PGB_A        328 PVMIAPDGARYSVdaeRKYVTWMDFSFYIAFNRDTGLSLFDIKYKGQRVLYELGLQEALAHYAANDPVQSSVAYLDSYYG 407  Aspergillus n...
XP_011424911  482 ANTVEPTGPRYRLk--GHTISWLGWEFSVTTSQHRGPAVFNVKFKGERVVYENALNDIGLLYSADGSGQDSIFYTDSTFG 559 
EEN53695      328 PELIEPDGRRYKVt--GRHVEYMGWSFDWRLATSSGPHLFDVRMNGERILYELALKEIATWYSGTDPV-TTAKFVDCGLP 404 
EEN53711      276 PELFEPDGRRYKAr--GRHVECMGWSFDWRLGITQGLQLYDVRVNGQRIVYELSSREAAAIYSGHDPKMLRSFFTDSGWS 353 
EDO40674      339 PEQYQPDGQRYAVd--DRRIEYMGWEFEFGNDPSYGLAAYDIRFNGERVVYELSLQEAVATYGGYFPSQTSMNFLDASWR 416 
XP_001627145  275 PELYEPDGKRYEVr--GRHVEYMNWAFDFRIDTLKGFQIYDIRFNGTRIIYELSLQEAIATYTGFSPVQGSNNFVDSNWF 352 
EKC26441      303 PILIEPDGKRYSVk--GQHVKYMNWDFDFRMSSTRGPQLYDIRFQNDRIVYELALQEVSVFYSGYKPTQMFSNYFDSTAM 380 
EKC41230      206 PIEVEPDGKRYSIk--DQTVTSDHWKFSFGISPTHGPQLYDIRYKGDLIVYELGLQEICVFYSSSEPFGRFANYFDSIVM 283 
EKC29982     1417 PMEIEPDGKRYSIk--DQAVTSDNWKFSFGISPTHGPQLYNIRYKDDLIVYELGLQEVCVFYSSTEPFGMFANTFDSIVM 1494
EKC36639      405 PKLVEPDGRRYRVd--GQHVSYMHWDFDFKMRPSTGLQVFDVRFQEERIAYEISLQDAVVFYSGYGPVQGTSMYFDASWM 482 
3PGB_A        408 FGPYAFELLKGYDCPSYASYLNTSFYKd--EETHTHVDSLCLFEFDADyPMARHSTSe------fVSVTKNVYFTLRSVS 479  Aspergillus n...
XP_011424911  560 LGESK-TAISDIDCPAHASYIKSVMWSp-tAMRGSELLTICIFEVDAQePLYRHKGDd------iEVGMRNRYLVARYPT 631 
EEN53695      405 AGG-YFELARGIDCPTTATFFDTVHMMd-rADPVIYKNSVCVFELNTGiPLRRHYESnfydgqsfYGGLVDNALVLRTIQ 482 
EEN53711      354 QGR-SYEVVRGVDCPKTAIFFDALHHRd-tAGPRRFKNAVCLFEMNSGiPLRRHFDSdyaggyefYGGMVAHALVLRHIF 431 
EDO40674      417 LGRSSYELVRGVDCPGHATFFDLTNFIg-tGEEETMRNAVCVFELNTGiPLRRHYDNdfagsykfYGGMVNTALVMRTVS 495 
XP_001627145  353 TGSNNHDLVPGVDCPGTATFFDVVHMAd-tSGPYTIKNAACLFELNSGiPLRRHYANdfssayrfYGGMTNQVLVLRTIA 431 
EKC26441      381 IGPQDKGLVPGVDCPSHATFKDVSHVMeasDKPITYKNAFCVFELNTGmPLRRHHSFssfh-gtmYEGVPNYVLVLRSIL 459 
EKC41230      284 IGRNMRTLVPGVDCPSHATFIDATWMSetsNKPFTSKKAICVFEHNTGiPLRRHYAAnefp-sgyFEGAPNVVLVLRMIG 362 
EKC29982     1495 IGRYVKTLVPGVDCPSHATFIDATFMSetsNTPVTNKKAICVFEHNTGsPLRRHHAPtenp-sgyYEGAPNVVLILRVIA 1573
EKC36639      483 MGATCNELVPGVDCPETAVFLDADFLTn-tQDPWRIKNSVCIFENTGNiPLRRHYTnfpg-gysgYAGLVDYHLIVRTIT 560 
3PGB_A        480 TIGNXDYMFSYNFHMDGTIGVEVRASGYIQSAYYAn-N----------QDFGYQIHDSLSGSM-HDHVLNFKADFDIlGP 547  Aspergillus n...
XP_011424911  632 QLGNYDYLIDFQFHMDGKIVTTATATGFIQASYYYinSqfvnpnnpgqTPFGYKVSNDIIGPI-HDHTFAFKVDLDVvSE 710 
EEN53695      483 TIGNYDLLYDFIFHQNGVLEVKASLNGYVWTSYYQa-Sq---------APYGYPTWGGSIANV-HQHFFNFKVDLDVgGT 551 
EEN53711      432 TIGNYDYIYDYIFHQNGVLEVSVTMTGYLQATFYTq-Ae---------AAYGYPAWANQVGNL-HQHGFSFKVDIDVlGT 500 
EDO40674      496 TVYNYDYIWDFIFYQNGVIEVKISASGYVMGSLYTd-Ev---------KNYAYKLY-KQLTSAtHDHLLNIKVDLDVaGI 564 
XP_001627145  432 TVGNYDYVHDAIFYQNGVIEVKMSASGFVFGSFYTp-Dv---------SPYGYPIHTNHLTSTtHDHLLHYKVDLDVeGT 501 
EKC26441      460 AVVNYSYLLDVIFYQTGAIEVKVVSTGYILATPFTa-Na---------KQFGVQVSDNINGNL-HHHMFSYKVDLDIeGT 528 
EKC41230      363 TLVNYDYIFDFIFYQNGAFETKVTSSGIIVSSFKTa-G----------SKYGFQVNEQALGTV-HNHFFNFKVDLDIgGA 430 
EKC29982     1574 TLANYDYLFDFMFYQNGVIETKVTASGIIASSYKSa-G----------PKYGFQVNEQALGTL-HNHFFNFKVDLDIgGP 1641
EKC36639      561 NIWNYDYIFDYIFHQNGAVQVRVSATGYVQATYALy-Ge---------RKFGYPIYNDVVANI-HQHLFNYKVDLDInGV 629 
3PGB_A        548 nNTIELVSVvpv--------tkqFSw----Sg-nK--TRNTMQLGRSFIHSEdeARL-NWGFNgQTQLHVVNQDKPNKFG 611  Aspergillus n...
XP_011424911  711 eNDFQLIHWkygnimdalktvkkENi----TfpgYffHNQTRYVEWEHVKNEraLNI---DSKnPKFWTFVNNNKLNSWG 783 
EEN53695      552 eNRFETVDIild--------nvtLPfrp-------nvRHFLTRFERNQKTREteATV-QYDFTkPKYYNFYSDNNKNRFN 615 
EEN53711      501 eNRQHTIDVvle--------nitNPerp-------dlRHIQTRLQRSVKNTEkeEAI-HYRFEqPKYYNFYNNLKKNRFG 564 
EDO40674      565 kNSYETIEIgie--------nvtSKwed-------nqRRVRKVLKRSTKSTEkdALY-KFDFDhPKYLNFYSE-KENRNG 627 
XP_001627145  502 aNSYETIEIgie--------nttNRfm-----pdYppHLFRKVLKPSVKKTEqeALY-KFNFDtPKYLNFFNEGKKNKMG 567 
EKC26441      529 qNRYRTLDIstt--------dspNRfh-----pnPnaKITQGQFVVSEKKSEmeAAY-KFNFDtPKYHLFYSNLKNNKFG 594 
EKC41230      431 qNSYSTYNIevd--------evpNPfskatPas----nWFQEKIVKVDYTTErdAAL-KFDFNiPKYHIFYNEDNLDEFG 497 
EKC29982     1642 qNSYSTYNVevd--------evpNNfskanSps----nWFQEKIVKVDYATEreAAY-KFDFNkPKYHVFYNENNLDKYG 1708
EKC36639      630 qNSYATLDVsth--------rteVAwsk-------gvHKTEMVFEKNIQENEldAGPgQLNNTkPKYDVILNMDATSKFK 694 
3PGB_A        612 EPRGYRILPsag---taHLTVLNSSNLVHAAHWAEYDVQVTRQHDFEPTSA-HPYNsQDIHNpp---vDFSTFF-NGESL 683  Aspergillus n...
XP_011424911  784 VSRGYRLVPmhsgtqniQD----DHPEAQHLSFTQHHLTVTKRKENEQYVKpI-YSpGNTKDpepsrkYVESMV-DGESI 857 
EEN53695      616 AHRGYRIQLngi---akNLLPKDGATAVNGAAWMDYQVAVTRRKDSEPSSS-SIFNqNDLYDpv---vNFQSFIdDDENI 688 
EEN53711      565 VHRGYRLQVngi---akTLLRREDWPAMRGVSWMDYQLAVTRRKESEPSSS-SIYNqNDLYDpv---vDFQSYInDNETI 637 
EDO40674      628 VKRGYRIQHagi---mkQLYP-EDWMIVPMVSWSLYQLAVTRYNESERRSS-SIYNqNSPTDtq---vDFRNFV-SDESI 698 
XP_001627145  568 VKKGYRIQHhgi---mkQLYP-EDFGMIPMISWSLYQLAVTRQKDSEPSST-SLYNqNAPSTph---iDFRDFVrDDEDI 639 
EKC26441      595 VPKSYRLLNrgm---skQLLP-ENVGNEPAMAWMRYQMAVTKRKEDERTSS-TIYSgLDALSpv---vNFDEFLnDDESI 666 
EKC41230      498 NVRAYRLLPkgf---akQVLP-EGVGNEPGCSWTRYQMAVTKRKENEPYSS-SKYVtYDGENpt---vDFEGFI-GNENI 568 
EKC29982     1709 NLRAYRLLPkgl---akKVMP-DGVGNEPGAPWMRYQMAVTQRKESEPYSS-SKYAsFDGENrt---vNFEDFI-GDENI 1779
EKC36639      695 SERGYRILNhgi---skFIL--QENEATKAANWAKYPLAVTKYHDFEDTSS-SIYAqNDPWDpl---lDFDKFIqNNDSI 765 
3PGB_A        684 NQTDLVVWLNLGMHHVPHTGDLPntVFTTAHSGVAFTPLNYLPGDPSR 731  Aspergillus nidulans
XP_011424911  858 ENTDIVAWVALGFLHIPTAEDVP--MTTKVTSGFTLKPFNFFDKTAVF 903 
EEN53695      689 VDEDLVAWVTLAAHHLPHSEDYPvtATAGNQLQFFIRPFHFYDEDPSM 736 
EEN53711      638 VDRDLVAWVTLGSHHIPDTSDYPttTTTGNHLKFFLRPFNYFDEDPSM 685 
EDO40674      699 VNQDLVAWVTMGMIHVPHSEDLPntGTVGSSASFFIRPFNYFDEDPSI 746 
XP_001627145  640 VNQDLVAWVTTGVMHVPHSEDIPttATPANAAGFFIRPFNYYDEDPSV 687 
EKC26441      667 VDEDLVAWVSMGVQHIPHTEDLPvtHTPGMDLSFFLLPYNYFPEDPAM 714 
EKC41230      569 INEDLVAWVTVGLHHIPRQEDIPimTTPGSEVSFYLLPFNYFPEDPSV 616 
EKC29982     1780 RNEDLVAWVTLGVHHIPRTEDLPimPTPGTEMSFLLLPFNYFPEDPSV 1827
EKC36639      766 VNTDIVAWVTMGLLHIPHTEDVPstTTAGSQVTFYLLPFNYFTECPSV 813 
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