1E8V,1Z4W,4JF7,1E8T,4FZH,1Z4X,3T1E,1V3D,1V2I,4MZE,4MZA


Conserved Protein Domain Family
HN
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cd15469: HN 
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Hemagglutinin-neuraminidase (HN) of parainfluenza virus 5, Newcastle disease virus, and related paramyxoviridiae
The hemagglutinin-neuraminidase (HN) found in this family of viruses has a variety of functions during viral infection; it participates in virus attachment to host cells, cleaves sialic acid off host oligosaccharides, and has a stimulating effect on membrane fusion during the entry of the virus into the host cell. This model characterizes the global ectodomain of HN. Hemagglutinin-neuraminidase ectodomains of these viruses attaches the virion to sialic acid receptors on host cells; the neuraminidase cleaves sialic acid moieties from host cell molecules as well as virus particles, this removal may happen in the trans Golgi network.
Links
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Statistics
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PSSM-Id: 271233
Aligned: 32 rows
Threshold Bit Score: 417.075
Created: 8-May-2014
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 7 residues -Click on image for an interactive view with Cn3D
Feature 1: active site [active site], 7 residue positions
Conserved feature residue pattern:R D E R R Y EClick to see conserved feature residue pattern help
Evidence:
  • Structure:1Z4W: Parainfluenza Virus 5 (Sv5) hemagglutinin-neuraminidase (HN) binds ligand AC1L9KL8 (DAN), contacts at 4A
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                   #                       #                                         
1E8V_A     37 LNFIPAPTTGSGCTRIPSFDMSatHYCYTHNVILSGCRDHsHSHQYLALGVLRTTATGRIFFSTLRSISLDDTQNRKSCS 116 Newcastle disease ...
1Z4W_A    116 PSFIPTATTPEGCTRIPSFSLTktHWCYTHNVILNGCQDHvSSNQFVSMGIIEPTSAGFPFFRTLKTLYLSDGVNRKSCS 195 Parainfluenza virus 5
4MZA_A     43 PGLLAMPTTVDGCVRTPSLVINdlIYAYTSNLITRGCQDIgKSYQVLQIGIITVNSDLVPDLNPRISHTFNINDNRKSCS 122 Human parainfluenz...
AFX75117  165 IPLVDYPGFSKSCTRFPSFSEGskFWCFTYAVVKEPCSDIsSSIQVVKYGAIKANHSDGNPYLVLGTKVLDDGKFRRGCS 244 Achimota virus 2
AHH02040  168 RDFVPSPGTFHGCSRFPSYSNHygLWCYSHTVSNDTCDGSnPSVQILSVGKLITGDNGQPEHKTLYTQQLSQTDRLYHCS 247 Sosuga virus
AFX75109  178 LNFVPNTGKLNGCTRTPSFSVYngFWCYTHAESDWNCNGSsPYMQVFRVGVVTSDYDYNVIHKTLHTKTSRLANVTYQCS 257 Achimota virus 1
Q91MJ8    177 LTFVRPIKNPQSCSRFPSYSVSfgVHCFANAVTDQTCELNqNTFYRVVLSVSKGNISDPSSLETKAETRTPKGTPVRTCS 256 Menangle virus
Q49HN3    177 PSFIPGSTKPGGCVRLPSFSLGleVFAYAHAITQDDCTSSsTPDYYFSVGRIADHGTDVPVFETLAEWFLDDKMNRRSCS 256 J-virus
Q287X2    182 PSFAPGSTKPGSCVRLPSFSLSttVFAYTHTIMGHGCSELdVGDHYFSVGRIADAGHEIPQFETISSWFINDKINRRSCT 261 Beilong virus
Q6YIS0    172 NSQIPGSTYSTGCVRIPTFSLGsmIYSYSHNVIYEGCNDHsKSSQYWQLGYISTSKTGEPLQQVSRTLTLNNGLNRKSCS 251 Fer-de-Lance param...

Feature 1                                                                                     
1E8V_A    117 VSATPLGCDMLCSKVTETEEEDYNSAVPTLMAHGRLGf--dGQYHEKDLDvttl--fedWVANYPGVGGGSFIDGRVWFS 192 Newcastle disease ...
1Z4W_A    196 ISTVPGGCMMYCFVSTQPERDDYFSAAPPEQRIIIMYy--nDTIVERIINppgv--ldvWATLNPGTGSGVYYLGWVLFP 271 Parainfluenza virus 5
4MZA_A    123 LALLNTDVYQLCSTPKVDERSDYASSGIEDIVLDIVNh--dGSISTTRFKnnnisfdqpYAALYPSVGPGIYYKGKIIFL 200 Human parainfluenz...
AFX75117  245 ITSSLYGCYLLCSTANVSEVNDYAHTPAYPLTLELISk--dGITTDLSPTytvq--ldkWSALYPGIGSGVIFKGYLMFP 320 Achimota virus 2
AHH02040  248 VTMTTLGCYILCSKPRVNETQDYETIGIEPMIIGMLGl--dGVYTDLGNPvgis--dnsLYAMYPGPGGGVMYKDFLVFP 323 Sosuga virus
AFX75109  258 TISTGYECYFLCSTPNVDEITDYKTPGIESLQIYKIDn--rGTFAKFPITdqln--kelLTALYPGPGNGVLYQGRLLFP 333 Achimota virus 1
Q91MJ8    257 IISSVYGCYLLCSKATVPESEEMKTIGFSQMFILYLSmdskRIIYDNIVSsts----aiWSGLYPGEGAGIWHMGQLFFP 332 Menangle virus
Q49HN3    257 VTAAGKGGWLGCSILVGSFTDELTSPEVNRISLSYMDt--fGKKKDWLYTgsevradqsWSALFFSVGSGVVIGDTVYFL 334 J-virus
Q287X2    262 VAAGAMEAWMGCVIMTETFYDDRNSLDTGKLTISYLDv--fGRKKEWIYTrseilydytYTSVYFSVGSGVVVGDTVYFL 339 Beilong virus
Q6YIS0    252 TVAQGRGAYLLCTNVVEDERTDYSTEGIQDLTLDYIDi--fGAERSYRYTnnevdldrpYAALYPSVGSGTVYNDRILFL 329 Fer-de-Lance param...

Feature 1                                                                                     
1E8V_A    193 VYGGLkpnsps---dtvqeGKYVIYKryndtcpdEQDYQIRMAKSSYkpGRFGGKRIQQAILSIKVstslgEDPVLTVPP 269 Newcastle disease ...
1Z4W_A    272 IYGGVikgtsl---wnnqaNKYFIPQmvaalcsqNQATQVQNAKSSYysSWFGNRMIQSGILACPLrqdltNECLVLPFS 348 Parainfluenza virus 5
4MZA_A    201 GYGGLehp---------inENAICNTt------gCPGKTQRDCNQAShsPWFSDRRMVNSIIVVDKglnsiPKLKVWTIS 265 Human parainfluenz...
AFX75117  321 VYGGLpfksplisaswvgpGNKWPVDfscs-edqYSTFNFSNPYSALysPHFSNNIVVSALFVCPLnenlpYSCEVQVLP 399 Achimota virus 2
AHH02040  324 LHGGVrfseaskmlgknitFRGFPPSdtc---teHEKSLTQEPANMLtsPYYGEVLVLDFLYVCTLldnipGECSIQLIP 400 Sosuga virus
AFX75109  334 MHGGMqsselnkvnlnntvLSQFNDNkgc---naTEIKLESEFPGTFtsPYYSNQVMLNYILICEMienlpGNCDLQIVA 410 Achimota virus 1
Q91MJ8    333 LWGGIpfltplg-qkilnsTLDIPEVgsk--cksDLTSNPAKTKDMLfsPYYGENVMVFGFLTCYLlsnvpTNCHADYLN 409 Menangle virus
Q49HN3    335 VWGGLnhp---------inVDAMCRAp------gCQSPTQSLCNYAIkpQEWGGNQIVNGILHFKHdtnekPTLHVRTLS 399 J-virus
Q287X2    340 IWGSLssp---------ieETAYCFAp------dCSNYNQRMCNEAQrpSKFGHRQMVNGILKFKTtstgkPLLSVGTLS 404 Beilong virus
Q6YIS0    330 GYGGLmtp---------ygDQAMCQAp------eCTSATQEGCNSNQliGYFSGRQIVNCIIEIITvgtekPIIRVRTIP 394 Fer-de-Lance param...

Feature 1             #                #                                                      
1E8V_A    270 NTVTLMGAEGRILTV--GTSHFLYQRGSSYFSPALLYPMTVsn----ktATLHSPYTFNafTRPGSIPCQASARCPNSCV 343 Newcastle disease ...
1Z4W_A    349 NDQVLMGAEGRLYMY--GDSVYYYQRSNSWWPMTMLYKVTItftngqpsAISAQNVPTQqvPRPGTGDCSATNRCPGFCL 426 Parainfluenza virus 5
4MZA_A    266 MRQNYWGSEGRLLLL--GNKIYIYTRSTSWHSKLQLGIIDItd----ysDIRIKWTWHNvlSRPGNNECPWGHSCPDGCI 339 Human parainfluenz...
AFX75117  400 QGNLTIGAEGRLYVI--DQDLYYYQRSTSWWPYLQLYKLNIritnrvfrVRSLSLLPIKstTRPGYGNCTYFKLCPHICV 477 Achimota virus 2
AHH02040  401 PDNMTMGSESKLYKL--NNSLLLYKRSSSWWPYTEVYQLSLrvsknsmkVRESVRLNITstTRPGVEGCNINKVCPKVCV 478 Sosuga virus
AFX75109  411 PKNMSMGSESQLYSI--NNKLYLYQRSSSRWPYPLIYEVGTrltnrqfrLRAINRFLIKstTRPGSEGCNIYRVCPKVCV 488 Achimota virus 1
Q91MJ8    410 STVLGFGSKAQFYDY--RGIVYMYIQSAGWYPFTQIFRITLqlkqnrlqAKSIKRIEVTstTRPGNRECSVLRNCPYICA 487 Menangle virus
Q49HN3    400 PDNNWMGAEGRLFHFhnSGKTFIYTRSSTWHTLPQVGILTLg------wPLSVQWVDITsiSRPGQSPCEYDNRCPHQCV 473 J-virus
Q287X2    405 PSVVPFGSEGRLMYSeiTKIIYLYLRSTSWHALPLTGLFVLg------pPTSISWIVQRavSRPGEFPCGASNRCPKDCV 478 Beilong virus
Q6YIS0    395 NSQVWLGAEGRIQTL--GGVLYLYIRSSGWHALAQTGIILTl------dPIRISWIVNTgySRPGNGPCSASSRCPAQCI 466 Fer-de-Lance param...

Feature 1                                        #                            #               
1E8V_A    344 TGVYTDPYPLIFyrn----htlRGVFGTMLDSEQARLNPASAVFDs-tSRSRITRVSSSsTKAAYTTSTCFKvvktnKTY 418 Newcastle disease ...
1Z4W_A    427 TGVYADAWLLTNpsststfgseATFTGSYLNTATQRINPTMYIANn-tQIISSQQFGSSgQEAAYGHTTCFRdtgsvMVY 505 Parainfluenza virus 5
4MZA_A    340 TGVYTDAYPLNPt--------gSIVSSVILDSQKSRVNPVITYSTs-tERVNELAIRNKtLSAGYTTTSCIThy--nKGY 408 Human parainfluenz...
AFX75117  478 TGVYQSPWLISIrdkrpheeknILYFIGWSPDEQIRQNPLVSLCHetaCFINRSLATNK-THAGYSESHCVQsfernKLT 556 Achimota virus 2
AHH02040  479 TGVFQAPGIIRKalspkesnedLLFFQAWTSDSIARQGPLISLCRadsCVLTIPLGNSD-VFIGYTDSFCLSdrdneKIY 557 Sosuga virus
AFX75109  489 TGVYQAPWILHVskagsqsiakVLYAVAWSKDHMSRKGPLFSICDndtCFLTKSLASEH-VHSGYSITRCYLenserHII 567 Achimota virus 1
Q91MJ8    488 TGLFQVPWIVNSdaitskevdnMVFVQAWAADFTEFRKGILSLCSqvsCPINDLLSKDN-SYMRDTTTYCFPqtvpnILS 566 Menangle virus
Q49HN3    474 TGVYTDLFPLGVs--------yEYSVTAYLDQVQSRMNPKIALVGa-qEKIYEKTITTNtQHADYTTTSCFAyk--lRVW 542 J-virus
Q287X2    479 TGVYTDLFPLGSr--------yEYAATVYLNSETYRVNPTLALINq-tNIIASKKVTTEsQRAGYTTTTCFVfk--lRVW 547 Beilong virus
Q6YIS0    467 TGVYTDIFPLSQn--------yGYLATVTLLSGVDRVNPVISYGTs-tGRVADSQLTSSsQVAAYTTTTCFTfn--qKGY 535 Fer-de-Lance param...

Feature 1          #                 
1E8V_A    419 CLSIAEISNTLFGEFRIVPLLVE 441 Newcastle disease virus
1Z4W_A    506 CIYIIELSSSLLGQFQIVPFIRQ 528 Parainfluenza virus 5
4MZA_A    409 CFHIVEINHKSLDTFQPMLFKTE 431 Human parainfluenza 3 virus (strain NIH 47885)
AFX75117  557 CTVFYELTAKPWAEMRVQSLLFQ 579 Achimota virus 2
AHH02040  558 CVALLELDNMPYSEMTIRSFLYL 580 Sosuga virus
AFX75109  568 CVVIMELDASPWAEMRIQSVIYN 590 Achimota virus 1
Q91MJ8    567 CTSFVEWGGDSGNPINILEIHYE 589 Menangle virus
Q49HN3    543 CVSIVEMSPGVITTRQPVPFLYH 565 J-virus
Q287X2    548 CISVVELAPSTMTAYEPIPFLYQ 570 Beilong virus
Q6YIS0    536 CYHIIELSPATLGIFQPVLVVTE 558 Fer-de-Lance paramyxovirus

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