1CRB,1JBH,5H8T,5LJB,5LJD,5LJC,5LJE


Conserved Protein Domain Family
CRBP1

?
cd19462: CRBP1 
cellular retinol-binding protein 1
Cellular retinol-binding proteins (CRBPs) participate in the cellular uptake of vitamin A in the form of free retinol. Retinol achieves a higher chemical stability when bound to CRBPs, and its interaction with retinol-binding proteins allows the solubilization in the aqueous medium of the hydrophobic retinol molecule. There are four human CRBP types (CRBP1, -2, -3, -4) which differ in their tissue-specific expression pattern, as well as in their different ligand affinities. CRBP1 (also known as Retinol-Binding Protein 1, CRBP, RBPC, CRBP1, CRBPI, CRABP-I) is widely expressed in numerous tissues: it has highest abundance in the liver, kidney, lung, and retinal pigment epithelium cells of the eye. CRBP1 has a high affinity for retinol. It accepts retinol transported from the plasma to cytosol via a cell surface receptor named STRA6, which interacts with serum retinol-binding protein. CRBP1 can bind all-trans-retinol, all trans-retinal and 13-cis-retinol, but not 9-cis-retinol. CRBPs belong to the intracellular fatty acid-binding protein (FABP) family, members of which are small proteins that bind hydrophobic ligands in a non-covalent, reversible manner, and, besides CRBPS, include the cellular retinoic acid-binding proteins (CRABPs) and the fatty acid-binding proteins (FABPs).
Statistics
?
PSSM-Id: 381237
Aligned: 9 rows
Threshold Bit Score: 255.68
Created: 13-May-2008
Updated: 2-Oct-2020
Structure
?
Program:
Drawing:
Aligned Rows:
 
retinol bindingligand binding
Conserved site includes 14 residues -Click on image for an interactive view with Cn3D
Feature 1:retinol binding site [chemical binding site]
Evidence:
  • Structure:1CRB, Rattus rattus cellular retinol-binding protein with bound retinol, contacts 4A
  • Citation:PMID 7683727

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Feature 1                  #   #        #   #  #   #          # #   ##   #              #     
1CRB_A      3 DFNGYWKMLSNENFEEYLRALDVNVALRKIANLLKPDKEIVQDGDHMIIRTLSTFRNYIMDFQVGKEFEEDLTGIDDRKC 82  black rat
AAH68742    4 NFNGYWKMLSNEHFEDYMKALDVNIAIRKIANLLKPDKEIIQNGDHMIIKTLSTFKNYIMEFDVGREFEEDLSGVDDRKC 83  African clawed frog
1JBH_A      4 DFNGYWKMLSNENFEEYLRALDVNVALRKIANLLKPDKEIVQDGDHMIIRTLSTFRNYIMDFQVGKEFEEDLTGIDDRKC 83  Norway rat
AAI55567    5 DMNGYWKMTSNENFDEYMEALDVNVVIRKIASYLILDKEIVQNGDHLYIKTLTTFRNYDMEFDVGKEFEEDLVGVDDRKC 84  zebrafish
5H8T_A      3 DFTGYWKMLVNENFEEYLRALDVNVALRKIANLLKPDKEIVQDGDHMIIRTLSTFRNYIMDFQVGKEFEEDLTGIDDRKC 82  human
5LJB_A      4 DFTGYWKMLVNENFEEYLRALDVNVALRKIANLLKPDKEIVQDGDHMIIRTLSTFRNYIMDFQVGKEFEEDLTGIDDRKC 83  human
5LJD_A      4 DFTGYWKMLVNENFEEYLRALDVNVALRKIANLLKPDLEIVQDGDHMIIRTLSTFRNYIMDFQVGKEFEEDLTGIDDRKC 83  human
5LJC_A      4 DFTGYWKMLVNENFEEYLRALDVNVALRKIANLLKPDKEIVQDGDHMIIRTLSTFRNYIMDFQVGKEFEEDLTGIDDRKC 83  human
5LJE_A      4 DFTGYWKMLVNENFEEYLRALDVNVALRKIANLLKPDLEIVQDGDHMIIRTLSTFRNYIMDFQVGKEFEEDLTGIDDRKC 83  human
Feature 1                            # #                         
1CRB_A     83 MTTVSWDGDKLQCVQKGEKEGRGWTQWIEGDELHLEMRAEGVTCKQVFKKV 133 black rat
AAH68742   84 MTTVNWRNDQLVCEQKGEKIGRGWTQWMEGDELHLEMRVGDVVCKQVFKKV 134 African clawed frog
1JBH_A     84 MTTVSWDGDKLQCVQKGEKEGRGWTQWIEGDELHLEMRAEGVTCKQVFKKV 134 Norway rat
AAI55567   85 MTTVNWEEDKLVCVQKGEKEGRGWTQWVKGDELHVEMRVCGVVCKQVFKRQ 135 zebrafish
5H8T_A     83 MTTVSWDGDKLQCVQKGEKEGRGWTQWIEGDELHLEMRVEGVVCKQVFKKV 133 human
5LJB_A     84 MTTVSWDGDKLQCVQKGEKEGRGWTQWIEGDELHLEMRVEGVVCKQVFKKV 134 human
5LJD_A     84 MTTVSWDGDKLQCVQKGEKEGRGWTQWIEGDELHLEMRVEGVVCKQVFKKV 134 human
5LJC_A     84 MTTVSWDGDKLQCVQKGEKEGRGWTLWIEGDELHLEMRVEGVVCKQVFKKV 134 human
5LJE_A     84 MTTVSWDGDKLQCVQKGEKEGRGWTLWIEGDELHLEMRVEGVVCKQVFKKV 134 human

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap