2PEF,3LE2,2DUT,2ZV6,2V95,4AJT,5C98


Conserved Protein Domain Family
Serpin

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pfam00079: Serpin 
Serpin (serine protease inhibitor)
Structure is a multi-domain fold containing a bundle of helices and a beta sandwich.
Statistics
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PSSM-Id: 459662
Aligned: 113 rows
Threshold Bit Score: 181.286
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2PEF_A    11 YNTADFSIELFKNSIDDKe----NSLISPLSAMLALAMTANGADNETLAQMEKALg-----------KDIS----IEDLN 71  Caldanaerobacter su...
Q5FW33   114 IINANFGFNLYRAIKNNTda-sdNILLAPVGISTAMATISLGTKGQALDQVLFTLgfknfinasskyEILTlhnvFRKLT 192 tropical clawed frog
CAF92600  35 AANREFAFRLYRSLAAQPdsrgkNVFFSPLSVSVALAALAVGARGETHQQLFRGLglsn-----tslSQAQvdqaFQSLF 109
Q8R4Z1    50 RHNMEFGFKLLQRLASNSrq--gNIFLSPLSISTAFSMLSLGAQNSTLEEIREGFnfk-------emSDRDmhmgFHYLL 120 Norway rat
P07758    46 TNLGDFAISLYRELVHQSnt--sNIFFSPVSIATAFAMLSLGSKGDTHTQILEGLqfnl-----tqtSEADihksFQHLL 118 house mouse
O54762    47 PNLAEFAFSLYRVLAHESnt--tNIFFSPVSIATALGSLSLGTKADTHTQIMEGVgfnl-----teiSEAEihqgFQHLL 119 thirteen-lined grou...
P20848    55 YNVTDLAFDLYKSWLIYHn---qHVLVTPTSVAMAFRMLSLGTKADTRTEILEGLnvnl-----tetPEAKihecFQQVL 126 human
Q9DCQ7    46 LTICNVSITLFKKMAQLSgn--gNILFSPIRVIAAISMLSLGSNGNLSKHILETLrfnk-----tglPEAEihkcFWYLL 118 house mouse
2V95_A    11 PTNVDFAFNLYQRLVALNpd--kNTLISPVSISMALAMVSLG---SAQTQSLQSLgfnl-----tetSEAEihqsFQYLN 80  Norway rat
Q5RIH8    31 IKNADFATRLYSKIASSSd---dNVAVSTLGATLALATLAAGAGGATQSELLQGIgvd------smvKDGEqe-rIQNIL 100 zebrafish
2PEF_A    72 KYLYTymkklpNEEKSKLTIANSIWFkENDFMPSKDFLQIIADYYKADIFKAAFDSS--TVSDINNWVKSKTNGMIDKIL 149 Caldanaerobacter su...
Q5FW33   193 HRLFR------RNFGYTLRSVNDIYV-KKDFVIREPFKNNLKNYYFAEAQMVDFGSKd-FLTKANKRIQQLTKGLIKEAL 264 tropical clawed frog
CAF92600 110 EQTRR-------TSSQVTREGTAVFV-DHLFKAQPGFLHTLKQSYFADGFAVDFSKSseSTDTINKYVKEKTSGKIDKLV 181
Q8R4Z1   121 QKLNR------ETQDVKMSIGNALFM-DQRLRPQQRFLKLAKNLYDADMILTNFQDLenTQKNINKYISRKTHNRIENMV 193 Norway rat
P07758   119 QTLNR------PDSELQLSTGNGLFV-NNDLKLVEKFLEEAKNHYQAEVFSVNFAESeeAKKVINDFVEKGTQGKIAEAV 191 house mouse
O54762   120 QNLNK------SNSQLQLTTGNGLFI-DHNMKLLDKFLEDIKNLYHSEAFSTDFTNTeeAKKQINTYVEKGTQGKIVDLV 192 thirteen-lined grou...
P20848   127 QALSR------PDTRLQLTTGSSLFV-NKSMKLVDTFLEDTKKLYHSEASSINFRDTeeAKEQINNYVEKRTGRKVVDLV 199 human
Q9DCQ7   119 HSIHQ------TEETSSLQTGSSVFI-HQDLTSVDKFVKGVKELYHSDMISINFTDSsqAKTQINNYVMEISQKAIVNIV 191 house mouse
2V95_A    81 YLLKQ------SDTGLEMNMGNAMFL-LQKLKLKDSFLADVKQYYESEALAIDFEDWtkASQQINQHVKDKTQGKIEHVF 153 Norway rat
Q5RIH8   101 QQLRE---------DAAQIPATGLFI-KQDVKADDSFSNQVKQYYNADVQNVNYANGqqAKGSINDYVRGRTGEKVRDVV 170 zebrafish
2PEF_A   150 NkIDPEDVMYLINAVAFDAEWETVYEKASVHEDIFTDVYGNRqKVEFMnSEENLYI---EEENavGFVK---PYaKNHYS 223 Caldanaerobacter su...
Q5FW33   265 TnVDPALLMLLVNCIYFKGTWENKFPVEYTQNMNFRLNEKELvKVPMM-KTKGNFLv--AADPelDCAVlqlPY-VGNIS 340 tropical clawed frog
CAF92600 182 KdLDPSTVMYLISYIYFKGKWESPFDPDLTQEDVFTVDEETKvPVQMM-NLERRFEt--YHDQtvNTSVlrlPF-NSSHS 257
Q8R4Z1   194 KnIDPGTVMLLTNYIYFQGRWQYEFDPKQTKEEDFFIEEGKTvKVPMM-FQRGMYDm--AYDSqlSCTIlemPY-RGNIT 269 Norway rat
P07758   192 KkLDQDTVFALANYILFKGKWKKPFDPENTEEAEFHVDESTTvKVPMM-TLSGMLHv--HHCStlSSWVllmDY-AGNAT 267 house mouse
O54762   193 KdLDRDSGLALVNYIFFKGTLEKPFKADHTMEQDFHVDEATTvRVPMM-NRLGMFDl--HYCPtlSSMVlkmKY-LGDIT 268 thirteen-lined grou...
P20848   200 KhLKKDTSLALVDYISFHGKWKDKFKAERIMVEGFHVDDKTIiRVPMI-NHLGRFDi--HRDRelSSWVlaqHY-VGNAT 275 human
Q9DCQ7   192 KnLESDTFLAVVNYIIWNAKLDSNFGCRSVKVKDYHLGYGMTiKVPMI-HNMAMHYlfrVGDL--SSTVlmlTLlTGNFA 268 house mouse
2V95_A   154 SdLDSPASFILVNYIFLRGIWELPFSPENTREEDFYVNETSTvKVPMM-VQSGSIGy--FRDSvfPCQLiqmDY-VGNGT 229 Norway rat
Q5RIH8   171 EnVDPQSMAILISAAFFTGQWLQPFNATFTQEDRFYVNKYNIvQVPMM-LRSGKYYla--ydPtfKVGIlklPC-ENGIA 246 zebrafish
2PEF_A   224 FVAILPde--nISvnEYIKTLTGQKFIDLIKNAKITLVR---ASLPKFKYEYTIKMNETLESLGMTDAFLpdKADFSKLG 298 Caldanaerobacter su...
Q5FW33   341 MLIVLPhklsgMK--LLEKQISPQVVERWQNIMTNRTRE---VFLPRFKLEKSYNLQEVLSNMGVTDLFT--HGDFSGVS 413 tropical clawed frog
CAF92600 258 MLLLLPe---hMA--QLEQALSPAHISKWLKWMKSRTFn---VYVPKFSIKTSASLKDVLTEMGMADMFGd-RADLTGIS 328
Q8R4Z1   270 ATFVLPds-gkLR--LLEQGLQADIFAKWKSLLS---KRvvdVWVPRLHISATYNMKKVLSRLGISKIFEe-HGDLTRIS 342 Norway rat
P07758   268 AVFLLPdd-gkMQ--HLEQTLSKELISKFLLNRR---RRlaqIHFPRLSISGEYNLKTLMSPLGITRIFNn-GADLSGIT 340 house mouse
O54762   269 AIFIMPkv-grME--YVEETLTKEFLDKLLKKDY---TGkntVHFPKLSISGTIDLKPVLTRLGITKVFSh-EADLSGIT 341 thirteen-lined grou...
P20848   276 AFFILPdp-kkMW--QLEEKLTYSHLENIQRAFD---IRsinLHFPKLSISGTYKLKRVPRNLGITKIFSn-EADLSGVS 348 human
Q9DCQ7   269 TYFIIPdp-gkMQ--KVEQSLTYPHFRRMRRQLL---TRlvdLEIPELSLSETHDLESMMSLLGITYVFNs-GTNSSDMN 341 house mouse
2V95_A   230 AFFILPdq-gqMD--TVIAALSRDTIDRWGKLMT---PRqvnLYIPKFSMSDTYDLKDVLEDLNIKDLLTn-QSDFSGNT 302 Norway rat
Q5RIH8   247 MLVLLPdedvdYT--YVDESMTGEVFRGWVAKLK---KTkleIQLPRFSLKQSNSLSVSLPSLGVKEIFGs-TANLTGIS 320 zebrafish
2PEF_A   299 ksdiGNLYISEVLHKTFISVDELGTKAGAVTsv---dITAAGIPVNFKTVKLNRPFIFAIIDNSTnLPIFIGTVLSL 372 Caldanaerobacter subte...
Q5FW33   414 d---KNMNIGLFQHQGTITVNEEGTEAAAVT------VVGFMPLSTQARFVADRPFLFLIYEHRTnCLIFMGRVANP 481 tropical clawed frog
CAF92600 329 e--gGRLSVSEVVHQATLDVDEAGATAAAATg----iGITLFSFHHVPVLKFDRPFMVIITEHSTeSILFLGKITNP 399
Q8R4Z1   343 s--hRSLKVGEAVHKAELRMNEKGTEGAAGS------GAQTLPMETPRRMKLNAPFLMMIYENLMpSMIFLARIYNP 411 Norway rat
P07758   341 ee-nAPLKLSQAVHKAVLTIDETGTEAAAVTvlqmvpMSMPPI------LRFDHPFLFIIFEEHTqSPIFLGKVVDP 410 house mouse
O54762   342 e--dAPLRVSQALHKAVLTIDEKGTEAERHTvkgpmaLTLAPE------VKFNRPFLVTLYDRSTkSPLFVGRVVNP 410 thirteen-lined ground ...
P20848   349 q--eAPLKLSKAVHVAVLTIDEKGTEATGAP------HLEEKAWSKYQTVMFNRPFLVIIKEYITnFPLFIGKVVNP 417 human
Q9DCQ7   342 d---TLQKSFKVVSKAVLTIDEKGSKPSTNS------CFKKLGSTDMGRMQLNRPFLIFIQDHTNdVPLFLGRVVNP 409 house mouse
2V95_A   303 k--dVPLTLT-MVHKAMLQLDEGNVLPNSTN------GAPLHLRSEPLDIKFNKPFILLLFDKFTwSSLMMSQVVNP 370 Norway rat
Q5RIH8   321 s--sEGLKLSEVVQKVAVDVDESGGSLAEAS-------GNLFMNPLPPRLTFNRPFIFVVYHEVTkCILYIGRVVDP 388 zebrafish
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