Conserved Protein Domain Family
FHA_TIFAB
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cd22715: FHA_TIFAB 
forkhead associated (FHA) domain found in TRAF-interacting protein with FHA domain-containing protein B (TIFAB)
TIFAB, also called TIFA-like protein, inhibits TIFA-mediated TRAF6 activation possibly by inducing a conformational change in TIFA. It regulates USP15-mediated p53 signaling during stressed and malignant hematopoiesis. It contains an FHA domain, which is a small phosphopeptide recognition module.
Links
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Statistics
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PSSM-Id: 438767
Aligned: 3 rows
Threshold Bit Score: 233.978
Created: 9-Sep-2020
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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putative
Feature 1:putative phosphopeptide binding site [polypeptide binding site]
Evidence:
  • Comment:Based on the structure evidence that Homo sapiens TIFA binds its Thr9 phosphorylated N-terminal peptide 1-15.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                            ###      # ## ##                          # 
Q6ZNK6         5 LTVLRVSLYHPtlgpsaFANVPPRLQHDt-sPLLLGRGQdAHLQLQLPRLSRRHLSLEPYLEKGSAlLAFCLKALSRKGC 83  human
XP_028668361   9 LAKIDITLYHPegqngiFQDVTKKDQCCifqNFSIGRSPkCNLQLNHKFISRRHFELEPYFIKGNPyLCFSLKNLSHKGI 88  reedfish
XP_007473421   5 MTILQISLYHPnqdkgvFEEIPHHLQLDt-tHLIIGRGRnAHLKFRLPGISRHHLSLEPYLEKGNVcLTFCLKILSRSSS 83  gray short-tail...

Feature 1                                                          
Q6ZNK6        84 VWVNGLTLRYlEQVPLStVNRVSFSGIQMLVRVEEGTSlEAFVCYFHVSP 133 human
XP_028668361  89 LKVNGMNIEYlQKTPIHaKNTILFSGFQMLVTVDQSVSwDGYVCEIHVSD 138 reedfish
XP_007473421  84 VWVNGLTLKYlEQVPLTaVSKVIFSGVQMVIDIQGGASkGKFACCIHFSC 133 gray short-tailed opossum

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