1RVK


Conserved Protein Domain Family
MR_like_4

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cd03329: MR_like_4 
Click on image for an interactive view with Cn3D
Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 4. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues, a Lys-X-Lys motif and a conserved histidine-aspartate dyad. This subgroup's function is unknown.
Statistics
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PSSM-Id: 239445
Aligned: 8 rows
Threshold Bit Score: 491.912
Created: 6-Oct-2005
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
metal bindingputative active
Conserved site includes 3 residues -Click on image for an interactive view with Cn3D
Feature 1:metal binding site [ion binding site]
Evidence:
  • Structure:1RVK; Agrobacterium tumefaciens hypothetical protein with bound Mg

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                       
1RVK_A        2 IITDVEVRVFrtttrrhsdsa----ghahpgpahqvEQAXLTVRTEDGQEGHSFTapei----vrpHVIEkfVKKVLIGe 73  Agrobacterium tu...
EAN04475     18 TIARVELFLFkqemqnvafdvsp-sgidmpdvrssrTRLAITLETRDGCKGEYIGgrs------diVPHLsfGAKRVLGq 90  Mesorhizobium sp...
BAC69118      2 KITHVEVHRIdvpaasppfrw----rdglsgsapvgDGAVLHIGTDEGAEGVSVFarpga-ystlrDLVDrvFRAELVGa 76  Streptomyces ave...
AAV47756      4 TITKIESREFeypledvgtdkhgfnlvyapgetitrKLFGVQIHTDEGITGEYVGgns------paAAQYniIAQYLIGk 77  Haloarcula maris...
YP_052164     2 KIESIDVTVFtyptrrvsdsa----ghshpgaenqaKMALLTITADDGQKGYAFAppev----irpHIVNafFRKVLIGq 73  Erwinia carotovo...
EAN08336      8 EITRIGVRVFsytsqirrafg-----hshpgpantaRQTLLEIETRGGAKGYAFGmq--------pELVDrvLVPMLIGe 74  Mesorhizobium sp...
ZP_00508822   2 KITDVTLTLFawenipatsyg-----ahtgrfsgesKLGLLAVTTDQGVTGHAFLgsafyaadmdgASLIryLKPLLLGq 76  Polaromonas sp. ...
EAN06298     85 KITDVTITMFekpippasyg------rhtlpgsgklTMGLLKVSTDEGVDGHAFLgspvrtaeldaASLIiaLKPVVVGr 158 Mesorhizobium sp...
Feature 1                                                                                       
1RVK_A       74 dhrdrERLWQDLAHwqrgsaaqltdrTLAVVDCALWDLAGRSLGQPVYKLIGgyrdKVLAYGSIxcgdeleg-glatped 152 Agrobacterium tu...
EAN04475     91 safdrERFYTDLRRhlrk----edriGLSQLDIVLWDWLGKQLGASVSDLLGggkdRLPAYASTwfggdgs--glehpea 164 Mesorhizobium sp...
BAC69118     77 dpfqrEWLWHRVWEldrih--elplpTLGLIDIALWDLAGRYHGEPVWRLLGgfreAIPAYASTstfs--------svae 146 Streptomyces ave...
AAV47756     78 dplkrEKHWSECKRalrk----ydrmGIGPIDIALWDFAGKYYDAPIHELLGtyreRIPTYASTyhgddag--gldspea 151 Haloarcula maris...
YP_052164    74 npfdrERLWQDLVHwqrgsanqltdrALSIVESALWDLQGRVLNMPVHKLLGgyreKVPAYGSTmcgdeleg-glstpee 152 Erwinia carotovo...
EAN08336     75 nalyrEKIWQKLSElqrgngatlsdaMMALVDVALWDLAGRAVGLPVQQLLGafrdKIPAYASTmvgdadlkggltspea 154 Mesorhizobium sp...
ZP_00508822  77 dpldrERLYKAMWKrvrt----ttvrAIGAVDIALWDIAGKAAGLPIHRLLGsyrdRVPAYISSavla--------spqa 144 Polaromonas sp. ...
EAN06298    159 dplqrEAIYKDLARragl----stwrCVGAIDVALWDIAGKVAGLPIYQLIGgfreKAPAYASSpgwa--------eveq 226 Mesorhizobium sp...
Feature 1                                                            #                          
1RVK_A      153 YGRFAETLvkrGYKGIKLHTwxppvswapdvkxdLKACAAVREAvgpdIRLXIDAFHwys-rtDALALGRGLEklgFDWI 231 Agrobacterium tu...
EAN04475    165 YADFAEECyglGYRAFKMHGwvdgn-----vereRSAILKLGDRvggrMNLMHDAAChlitfaDALAVGRACDeagFFWY 239 Mesorhizobium sp...
BAC69118    147 FLDVADQClalGYRGIKLHAwgda-------rrdAELCLALRDHvgpdVPLMYDGSAgfd-lpDAIRLGRALSeadYLWY 218 Streptomyces ave...
AAV47756    152 FADFAEECrdeGFGGFKIHGwgggdda-rsldreVEAVHAVGEAvgdeMDLMHDPACeletfaDALELGRALDeqdFFWY 230 Haloarcula maris...
YP_052164   153 FGQFAEKLvqrGYKAIKLHTwmppvsfapspkidVKACAAVREAvgpdVCLMLDGYHwys-rsDALYIGRELQkldFTWF 231 Erwinia carotovo...
EAN08336    155 YADFAIQCkeeGYTAYKMHPwmppvpgapsvdrdLAMATAVRKAvgpeMHLMFDPYHqys-rqEAKRLGRGLEelgFLWM 233 Mesorhizobium sp...
ZP_00508822 145 YAEEALHYkslNMAAYKIHPpqaw-------rddIKVCEAVRKAvgddYLLMLDSVWsyd-yaAALRVGQAIEalgYYWY 216 Polaromonas sp. ...
EAN06298    227 YVEEAQTVkahGYAAYKVHPprlg------wemdLKVARAVRRVvgdhYRLMFDSTGvyt-yaEALKVGRELEelgYYWF 299 Mesorhizobium sp...
Feature 1       #                           #                                                   
1RVK_A      232 EEPXdeq--slSSYKWLSdnldIPVVGPESAagkhWHRAEWIka-gACDILRTGVNDVggITPALKTXHLAeafgXECEV 308 Agrobacterium tu...
EAN04475    240 EDPYsdlglsaHSHRRLRellkTPILLGEHVrg-lESLATLVla-gGTDFVRADPNFDigITGTMKIAHFAealgIDVEL 317 Mesorhizobium sp...
BAC69118    219 EEPIref--siSAYQRLAeavdVPLLVAETSdgahMNAADFIragaATFGVRAGTTLRggITGAMRTAHLAdafrLRAEV 296 Streptomyces ave...
AAV47756    231 EDPFrdggisqHAHKKLAqkldTPILQTEHIrg-lEIKSDFAas-eATDFLRADPEYDagITGAIKVARMAeafgLDVEF 308 Haloarcula maris...
YP_052164   232 EEPMeeq--smASYSWLTksldIDVIGPESLsgkyFSRADWVke-gACDILRAGVQGVggLWPCLKVASLAesfgMDCEI 308 Erwinia carotovo...
EAN08336    234 EEPMrea--siSSYRWLCdeldLPICGPETApgqiWTRAEWVla-gACDILRTGVLDVggITPMMKTIHLAeahgMSIEL 310 Mesorhizobium sp...
ZP_00508822 217 EDPLada--diYNYVELRkklrIPIMATEYPagglDAYAPWIme-rATDFLRGDVAVKggITTLIKTAHLAeafhLNYEL 293 Polaromonas sp. ...
EAN06298    300 EDPLpfe--diYNYTKLKqkleIQIMATELSpgafHAYEPWVsq-kATDALRGDVALKggITACLKTAHLAeafrLNYEL 376 Mesorhizobium sp...
Feature 1                                                                                       
1RVK_A      309 Hgn-----tAXNLHVVaatk-ncrWYERgllhpfleydd---ghdylkslsdPXDRDGFVHVPDRPGLGEDIDFTFIDNN 379 Agrobacterium tu...
EAN04475    318 Hgc-----gPAHRQCMaair-ntnYYELsmvspsrgqpvnpfyaggysdlldDVDSDGSFPVPKGPGLGVEYDWDVVTRN 391 Mesorhizobium sp...
BAC69118    297 Hgs-----dIPNHHLCmais-nttYYESlvtsvn-------------vvrerHVDDQGLVHAPAGPGIALPLDFGYGNEL 357 Streptomyces ave...
AAV47756    309 Hap-----gPAQRHCIaacr-nsnYYEMalvhpdcqntqppvyeggysdlmdAVDNDGTVSVPDGPGLGVEYDWDYIEDN 382 Haloarcula maris...
YP_052164   309 Hgn-----gAPNLNVVgaik-ncrWYERgllhpfldyde---paaylnsivdPMDDEGFVHLPQRPGLGEDINFDWIEEH 379 Erwinia carotovo...
EAN08336    311 Hqn-----gAATLHALgamqipgrFYERgllhplikyes---ktpwlatiddPMDAEGFVHVPKGPGMGWDIDWDFIAGN 382 Mesorhizobium sp...
ZP_00508822 294 HhggnslnnFANLHVImaiq-nteFFEVllpaesqk---------ygllqdiVIDSDGMVYAPTGSGLGATIDFELIERK 363 Polaromonas sp. ...
EAN06298    377 HhggnslnnVANLHVFcaip-nteFFEVvlpdeaqk---------cglvvdlSVGSDGFVHVPKGPGLGAEIDFDLIEKS 446 Mesorhizobium sp...

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