Conserved Protein Domain Family
trimeric_dUTPase

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cl00493: trimeric_dUTPase Superfamily 
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Trimeric dUTP diphosphatases
Trimeric dUTP diphosphatases, or dUTPases, are the most common family of dUTPase, found in bacteria, eukaryotes, and archaea. They catalyze the hydrolysis of the dUTP-Mg complex (dUTP-Mg) into dUMP and pyrophosphate. This reaction is crucial for the preservation of chromosomal integrity as it removes dUTP and therefore reduces the cellular dUTP/dTTP ratio, and prevents dUTP from being incorporated into DNA. It also provides dUMP as the precursor for dTTP synthesis via the thymidylate synthase pathway. dUTPases are homotrimeric, except some monomeric viral dUTPases, which have been shown to mimic a trimer. Active sites are located at the subunit interface.
Links
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Taxonomy: root
PubMed: 23 links
Protein: Related Protein
Related Structure
Statistics
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Accession: cl00493
PSSM Id: 444938
Name: trimeric_dUTPase
Created: 8-Feb-2008
Updated: 4-Oct-2023
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