1BFB,1BAS,1BFF,1BFG,1BLA,1CVS,1FGA,1II4,2BFH,2M49,4FGF,6L4O


Conserved Protein Domain Family
beta-trefoil_FGF2

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cd23314: beta-trefoil_FGF2 
FGF domain, beta-trefoil fold, found in fibroblast growth factor 2 (FGF2) and similar proteins
FGF2, also called basic fibroblast growth factor (bFGF), or heparin-binding growth factor 2 (HBGF2), acts as a ligand for fibroblast growth factor receptors, FGFR1, FGFR2, FGFR3, and FGFR4. It also acts as an integrin ligand which is required for FGF2 signaling. FGF2 plays an important role in the regulation of cell survival, cell division, cell differentiation, and cell migration. It functions as a potent mitogen in vitro. It can induce angiogenesis. FGF2 contains a FGF domain with beta-trefoil fold, which is characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry.
Statistics
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PSSM-Id: 467000
Aligned: 19 rows
Threshold Bit Score: 241.286
Created: 2-Apr-2021
Updated: 27-Apr-2023
Structure
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Program:
Drawing:
Aligned Rows:
 
ligand binding
Conserved site includes 7 residues -Click on image for an interactive view with Cn3D
Feature 1:ligand binding site [chemical binding site]
Evidence:
  • Structure:1BFB; Homo sapiens FGF-2 in complex with heparin fragment, contacts at 4A
  • Citation:PMID 8599088

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                #                                                                       
1BFB_A        20 DPKRLYCKNGGFFLRIHPDGRVDGVREKsDPHIKLQLQAEErGVVSIKGVsANRYLAMKEDGRLLASKSVTDECFFFERL 99  human
1BFF_A         2 DPKRLYCKNGGFFLRIHPDGRVDGVREKsDPHIKLQLQAEErGVVSIKGVcANRYLAMKEDGRLLASKCVTDECFFFERL 81  human
1FGA_A        19 DPKRLYCKNGGFFLRIHPDGRVDGVREKsDPHIKLQLQAEErGVVSIKGVcANRYLAMKEDGRLLASKCVTDECFFFERL 98  human
2BFH_A         1 DPKRLYCKNGGFFLRIHPDGRVDGVREKsDPHIKLQLQAEErGVVSIKGVcANRYLAMKEDGRLLASKCVTDECFFFERL 80  human
4FGF_A        19 DPKRLYCKNGGFFLRIHPDGRVDGVREKsDPHIKLQLQAEErGVVSIKGVcANRYLAMKEDGRLLASKCVTDECFFFERL 98  human
P12226        28 DPKRLYCKNGGFFLRINSDGRVDGSRDKsDSHIKLQLQAVErGVVSIKGItANRYLAMKEDGRLTSLRCITDECFFFERL 107 African clawed ...
P48800        31 DPKRLYCKNGGFFLRINPDGRVDGVREKsDPHIKLQLQAEErGVVSIKGVsANRFLAMKEDGRLLALKCATEECFFFERL 110 chicken
NP_997988     27 DPKRLYCKNGGFFLRINADGRVDGARDKsDPHIRLQLQATAvGEVLIKGIcTNRFLAMNADGRLFGTKRTTDECYFLERL 106 zebrafish
P09038       161 DPKRLYCKNGGFFLRIHPDGRVDGVREKsDPHIKLQLQAEErGVVSIKGVcANRYLAMKEDGRLLASKCVTDECFFFERL 240 human
XP_005994763  28 EPKRLYCKNGGYFLRINPDGRVDGTREKnDPYIKLQLQAESiGVVSIKGVcSNRYLAMNEDCRLFGLKYPTDECFFHERL 107 coelacanth
Feature 1                            ##    #        ###       
1BFB_A       100 ESNNYNTYRSRKYtSWYVALKRTGQyKLGSKTGpGQKAILFLPMS 144 human
1BFF_A        82 ESNNYNTYRSRKYtSWYVALKRTGQyKLGSKTGpGQKAILFLPMS 126 human
1FGA_A        99 ESNNYNTYRSRKYtSWYVALKRTGQyKLGSKTGpGQKAILFLPMS 143 human
2BFH_A        81 ESNNYNTYRSRKYtSWYVALKRTGQyKLGSKTGpGQKAILFLPMS 125 human
4FGF_A        99 ESNNYNTYRSRKYtSWYVALKRTGQyKLGSKTGpGQKAILFLPMS 143 human
P12226       108 EANNYNTYRSRKYsSWYVALKRTGQyKNGSSTGpGQKAILFLPMS 152 African clawed frog
P48800       111 ESNNYNTYRSRKYsDWYVALKRTGQyKPGPKTGpGQKAILFLPMS 155 chicken
NP_997988    107 ESNNYNTYRSRKYpDWYVALKRTGQyKSGSKTSpGQKAILFLPMS 151 zebrafish
P09038       241 ESNNYNTYRSRKYtSWYVALKRTGQyKLGSKTGpGQKAILFLPMS 285 human
XP_005994763 108 ESNNYNTYRSKKYsDWYVALKRTGQyKPGPKTGlGQKAILFLPMS 152 coelacanth

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