Conserved Protein Domain Family
Dpy19L3
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cd20181: Dpy19L3 
C-mannosyltransferase Dpy-19-like protein 3 (Dpy19L3)
Dpy19 proteins are C-mannosyltransferases that mediate C-mannosylation of tryptophan residues on target proteins. C-mannosylation is the attachment of alpha-mannose to the indole C2 carbon of the first tryptophan residue in the consensus amino acid sequence Trp-Xaa-Xaa-Trp/Cys through a C-C bond. This reaction takes place in the endoplasmic reticulum (ER) lumen. Dpy19 is a transmembrane domain family whose name is derived from the Caenorhabditis elegans Dumpy mutant. In humans Dpy19L3 (also called protein Dpy-19 homolog 3) is a C-mannosyltransferase of R-spondin.
Links
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Statistics
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PSSM-Id: 439134
Aligned: 6 rows
Threshold Bit Score: 1176.93
Created: 6-Feb-2019
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Feature 1: glycosylation site [posttranslational modification site], 1 residue position
Conserved feature residue pattern:NClick to see conserved feature residue pattern help
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                #       
NP_001166245  46 SLTIGGTIALCIGLLTSvYLATLHENDLWFSNIKEVEREISFRTECGLYYSYYKQMLQAPTLvqGFHGLIYDNKTESMKT 125
XP_005998407  43 STLLGTLAAVCLGLLTSvYVATLHENDLWFSNIKEIEREISFRTECGLYYSYYKQMVQAPSIrqGFYELMYDNKTESRRT 122 coelacanth
Q71B07        46 SSAVGGTVALCIGLLTSvYLATLHENDLWFSNIKEVEREISFRTECGLYYSYYKQMLQAPTLlqGFHGLIYDNKTESMRT 125 house mouse
AWP02021      49 WTSVGWSVSVGLGLLCCiYVATLHENDLWFSNIKEVEREISFRTECGLYYSYYKQMLQAPSIqeGLSDLIHDNLTESKRT 128 turbot
Q6ZPD9        46 SLTIGGTIALCIGLLTSvYLATLHENDLWFSNIKEVEREISFRTECGLYYSYYKQMLQAPTLvqGFHGLIYDNKTESMKT 125 chimpanzee
PKK25790      48 SVTVGGIVAISVGLLTSvYVATLHENDLWFSNIKEVEREISFRTECGLYYSYYKQMIQAASIqqGLHGLVYDNKTESVRT 127 rock pigeon

Feature 1                                                                                        
NP_001166245 126 INLLQRMNIYQEVFLSILYRVLPIQkYLEPVYFYIYTLFGLQAIYVTALYITSWLLSGTWLSGLLAAFWYVTNRIDTTRV 205
XP_005998407 123 INILKRMNIYQEVLLSVLYRLLPIQnYLEPVYFYIYSVFGLQTVYVIALYLTSWILSGTWLSGVLAAVWYILNRIDTTRV 202 coelacanth
Q71B07       126 INLLQRMNIYQEVFLSVLYRVLPIQkYLEPVYFYIYTLFGLQAVYVTALYITSWLLSGTWLSGLLAALWYVTNRIDTTRV 205 house mouse
AWP02021     129 INLLQRMNIYQEVFLSVLYRLLPIQsYLEPVYFYIYTVFSLQAVYVIALYLTAWLLSGSWLAGTLTGVWYILNRVDTTRV 208 turbot
Q6ZPD9       126 INLLQRMNIYQEVFLSILYRVLPIQkYLEPVYFYIYTLFGLQAIYVTALYITSWLLSGTWLSGLLAAFWYVTNRIDTTRV 205 chimpanzee
PKK25790     128 INILERMNVYQEVFLSILYRILPIQqYLEPVYFYIYTLFGLQAVYVIALYVTSWLLSGTWLSGLLAACWYITNRVDTTRV 207 rock pigeon

Feature 1                                                                                        
NP_001166245 206 EFTIPLRENWALPFFAIQIAAITYFLRPNLqplsERLTLLAIFISTFLFSLTWQFNQFMMLMQALVLFTLDSLDMLpavk 285
XP_005998407 203 EFTIPLRENWSLPFFALQIAAVTYFLRTPInslqQRLTLALVLMSTLFFSLTWQFNQFILLIQALTLFMLDCLDMVptak 282 coelacanth
Q71B07       206 EFTIPLRENWALPFFAIQIAAITYFLRPNLqplsERLTLLAIFVSTFLFSLTWQFNQFMMLLQALVLFILDSLDMLpamk 285 house mouse
AWP02021     209 EFTISLRENWSLPFLALQVTTITCYLRPQLtalqQKVMVWLMYVTTFFFCLTWQFNQFILLVQALIIYTLDCVDFLtttq 288 turbot
Q6ZPD9       206 EFTIPLRENWALPFFAIQIAAITYFLRPNLqplsERLTLLAIFISTFLFSLTWQFNQFMMLMQALVLFTLDSLDMLpavk 285 chimpanzee
PKK25790     208 EFTIPLRENWALPFFAVQIAAITYLLRTHLqpvqEKMTLLAVFISTFLFSLTWQFNQFMMLIQALALFILDCFDMLptak 287 rock pigeon

Feature 1                                                                                        
NP_001166245 286 atwLYGIQITSLLLVCILQFFNSMILGSLLISFNLSVFIARkLQKNLKTGSFLnrlgKLLLHLFMVLCLTLFLNNIIKKI 365
XP_005998407 283 vswLYIVQVVCLLLVWILQFFNSMILGSLVLSFILAALIVKhLQKNVKTGGFLvrigKLLAHVALVLCLTLLVNNFVKKI 362 coelacanth
Q71B07       286 atwLYGIQISCLLLVCTLQFFNSMILGSLLISFNLSVLIVRkLQKNLKTGSFLtriwKLLLHLLLVFCLTLFLNNIIKKV 365 house mouse
AWP02021     289 vttLYLVQVSGLLSVWLLQFCNSMILGSLVLSFIVAALFVRhCQSGLKTGSLLarlgKLLLHTAMVLLLTFTINYLAKKA 368 turbot
Q6ZPD9       286 atwLYGIQITSLLLVCILQFFNSMILGSLLISFNLSVFIARkLQKNLKTGSFLnrlgKLLLHLFMVLCLTLFLNNIIKKI 365 chimpanzee
PKK25790     288 vmwLYIIQISGLLLVCVLQFFNSMILGSLLLSFNASVLIARtIQKNLKKGTLLnrlgKLILHVLLVMWLTFLINKFIKKI 367 rock pigeon

Feature 1                                                                                        
NP_001166245 366 LNLKSDEHIFKFLKAKFGLGATRDFDANLYLCEEAFGLLPFNTFGRLsdTLLFYAYIFVLSITVIVAFVVAFhnlsdstn 445
XP_005998407 363 LQLESDEHIFKFIKAKFGFGATRDFDAKLYLCEEAFGVLPFDTFERLsdTLLFCAHIFILLALIIIAAVSVLqilsgyai 442 coelacanth
Q71B07       366 LNLKSDEHIFKFLKAKFGFGATRDFDANLYLCEEAFGLLPLNTFQRLseTLLFYAYMFVLVVTVVTASVVAFhnlsdsts 445 house mouse
AWP02021     369 LQLKSDEHIFKFIKSKFALGPTRDFDASLYLCEEAFGLLPFDTLERLagTLLLYPYVLTLLLLGGMMAVSALhnlrpkgv 448 turbot
Q6ZPD9       366 LNLKSDEHIFKFLKAKFGLGATRDFDANLYLCEEAFGLLPFNTFGRLsdTLLFYAYIFVLSITVIVAFVVAFhnlsdstn 445 chimpanzee
PKK25790     368 LHLESDEHIFKFLKAKFGFGATRDFDANLYLCEEAFGLLPLNTFSRLsdTLLFYVYVFVLFLVTVAAVIVAFqnlsdsnq 447 rock pigeon

Feature 1                                                                                        
NP_001166245 446 qqs--vgkmekgtvdLKPETAYNLIHTILFGFLALSTMRMKYlWTSHMCVFASFGLCSPEIWELLLksvhlynpkricIM 523
XP_005998407 443 pqn-sdgkeeesafmLRPEVAYNFLHNFLFGILAISTMRMKYlWTSHVCVLASFGICSTELWRLVLkmirlytpqkvqVL 521 coelacanth
Q71B07       446 lks--mdqtrkravdLKPEAAYNLIHTILFGVLALSTMRMKYlWTSHMCVFASFGLCSSEVWELLLrlvhlcnpkriwVL 523 house mouse
AWP02021     449 saeerkgagegheaaLRPDVAYNLLHTLFYGLLAFSTMRMKYiWTGHMCAVAAYGVCGTELWTPLLttlrcnskvmlrLV 528 turbot
Q6ZPD9       446 qqs--vgkmekgtvdLKPETAYNLIHTILFGFLALSTMRMKYlWTSHMCVFASFGLCSPEIWELLLksvhlynpkricIM 523 chimpanzee
PKK25790     448 vqf--mekmeectitLKPDAAYNFIHTVLFGCLAFSTMRMKYlWTSHMCVFASFGLCSTEVWKLILkcihlytpqrtrMM 525 rock pigeon

Feature 1                                                                                        
NP_001166245 524 RYSVPILILLYLCYKFWPGMMDELSELREFYDPDTVELMNWINSNTPrkAVFAGSMQLLAGVKLCTGRTLTNHPHYEDSS 603
XP_005998407 522 RFAVPVLLLLYLSYKFWPRLIEELSDLREFYDPDTVELMNWIKSKTPkdAVFAGSMQLLAGVKLCTGRTITNHPHYEDKN 601 coelacanth
Q71B07       524 RYLVPVLTLLYLCYKSWPGVMDELSELKEFYDPDTVELMTWINSNTPrkAVFAGSMQLLAGVKLCTGRTLTNHPHYEDKS 603 house mouse
AWP02021     529 RYAVPLAMIGCLYYKFWPKLMEELSELREFYDPDTVELMTWISTKTPkrAVFAGSMQLLAGVKLCTGRVVTNHPHYEDKD 608 turbot
Q6ZPD9       524 RYSVPILILLYLCYKFWPGMMDELSELREFYDPDTVELMNWINSNTPrkAVFAGSMQLLAGVKLCTGRTLTNHPHYEDSS 603 chimpanzee
PKK25790     526 KYSIPIITLLYISYKFWPGIMDELSELREFYDPDTVELMNWIKSNTPntAVFAGSMQLLAGVKLCTGRTLTNHPHYEDKN 605 rock pigeon

Feature 1                                                                                        
NP_001166245 604 LRERTRavYQIYAKRAPEEVHALLRSFGTDYVILEDSICYERRHrRGCRLRDLLDIANGHMMDGPGENDPDLKPADHPRF 683
XP_005998407 602 LRERTKqvYQIYAKQPPEKVYGTLRSFGTNYVILEDSICYERRHsRGCRLRDLLDTENGHIMDGPGENAPGLKPSSYNRF 681 coelacanth
Q71B07       604 LRERTQavYQIYAKRSPEEVHALLRSFGTDFVILEDSICYERRHhRGCRLRDLLDVANGHEMDGPGESDPDLRPADHPRF 683 house mouse
AWP02021     609 LRERTRqvYQVYARQSAEDVHDILRAAGADYVVLENSICYERRHrRGCRLRDLLDLANGHIMDGPGDNDPDLTPASHPRF 688 turbot
Q6ZPD9       604 LRERTRavYQIYAKRAPEEVHALLRSFGTDYVILEDSICYERRHrRGCRLRDLLDIANGHMMDGPGENDPDLKPADHPRF 683 chimpanzee
PKK25790     606 LRERTKqiYQIYAKRSPEDVYRILRSFGTDYVILEDSICYERRHsRGCRLRDLLDIANGHIMDGLGENEPDLKPSLYPRF 685 rock pigeon

Feature 1                                     
NP_001166245 684 CEEIKRNLPPYVAYFTRVFQNKTFHVYKL 712
XP_005998407 682 CDEIKANVSSFSIYFTRVFQNKTFHVYKL 710 coelacanth
Q71B07       684 CEEIKRNLPSYAAHFTRVFQNKTFHVYKL 712 house mouse
AWP02021     689 CEAIKTDTADYAALFTRTFENKTFHLRRE 717 turbot
Q6ZPD9       684 CEEIKRNLPPYVAYFTRVFQNKTFHVYKL 712 chimpanzee
PKK25790     686 CEEIKKNLPSYTVHFTRVFQNKTFHVYKL 714 rock pigeon

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