2NRA


Conserved Protein Domain Family
Rep_3

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pfam01051: Rep_3 
Initiator Replication protein
This protein is an initiator of plasmid replication. RepB possesses nicking-closing (topoisomerase I) like activity. It is also able to perform a strand transfer reaction on ssDNA that contains its target. This family also includes RepA which is an E.coli protein involved in plasmid replication. The RepA protein binds to DNA repeats that flank the repA gene.
Statistics
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PSSM-Id: 460042
Aligned: 159 rows
Threshold Bit Score: 42.6515
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2NRA_C                 11 KKTKIRHRNELNHTLaq--------lPLPAKRVMYMALALIDSKEPlergrvfkiraEDLA-------ALAKITpslaYR 75  Escher...
EAY25477               13 QDARVTLSNKFLL-------------SEMEINIFYLLVSQIRQDDDdlkey--vinlKDLEllt--grTQKKGTllkvCE 75 
Q7WWW9                 19 RGQSVTEAPKDLGFRrsnafvkiidlSLAGRRLIDVAYFLVAEDQEvr-------reYRVDvglfkwlLATTSNnrrhLS 91  Cupria...
Q6U5H5                 22 VIHLVPNSKQSIQPK-----------SLLRLGVFVPTVKDGSDPMArg-------hvIDATtelcrlsSIAGEG----YE 79  Klebsi...
WP_011906524           17 THQLTVTSNSSVQPA-----------ILLRLGVFVPASRAIPKGLKs---------gIDVSssfsqleFARKEG----YD 72  Entero...
Q71TA8                 18 AKELTVNSNNTVQPV-----------ALMRLGVFVPKPSKSKGESk----------eIDATkafsqleIAKAEG----YD 72  Escher...
Q6U5J6                 22 VVKLDVNSTSTVQPV-----------ALMRLGLFVPTLKSTSRSKAnrk------nvTDATeelvqlsIAKSEG----YT 80  Klebsi...
CAS07437                8 VVNLTPNASNTVQPV-----------ALMRLGVFVPTLKSLKNSKKntl------srTDATeeltrlsLARAEG----FD 66 
wugsc:KPN_pKPN4p07092  20 NKKLMPSRNATVQPV-----------ALMRLGLFLPSLKRKGKDTEni--------sIDASselqsleLARAEG----YT 76 
Q8E8A8                 20 GKLLTISSTTSVQPN-----------VLLRTGVFTPVGRRTNANDVk---------aQDLSndlvnldVCQKEG----YD 75  Shewan...
2NRA_C                 76 QLKEGGKLLGaskisLRGddiialakelnllstaknsseeldlniieWIAYSPdeGYLSLKFTRTIEPYISSLigkKNkF 155 Escher...
EAY25477               76 KLKKQTIVLkd---vVSVtdgkeyef--------------ivenligAIKKPKnkQEIRTTISPDVRQFYINL---KKhY 135
Q7WWW9                 92 KLVREAQKAAielneIDVedpskdrw--------------gavplmgSAFIEK--GEFIFELPERLQRAIKNP---KS-- 150 Cupria...
Q6U5H5                 80 KISIFGPRLDmd-tdFKV-----------------------------WLGIVDtlANTFLEPDGTVRVNFIDF---AF-S 125 Klebsi...
WP_011906524           73 EVRIFGERLNis-tdFSV-----------------------------WMGIIGafSKYGL-KSNTIELPFTEF---AA-L 117 Entero...
Q71TA8                 73 DIKITGPRLDmd-tdFKT-----------------------------WIGVIYafSKYGL-SSNTIQLSFQEF---AK-A 117 Escher...
Q6U5J6                 81 DVKITGSRLDmd-tdFKV-----------------------------WLGIIRsmSEYGV-KSDTLELSFVEF---VK-M 125 Klebsi...
CAS07437               67 KVEITGPRLDmd-ndFKT-----------------------------WVGVIHsfARHKV-IGDKVELPFVEF---AK-L 111
wugsc:KPN_pKPN4p07092  77 DIRITGPRLSme-tdFKV-----------------------------WVGIILafSKYGL-NSSTIELPFSEF---AT-F 121
Q8E8A8                 76 LVTVRGQRLNie-tdFKV-----------------------------WCGIVLvfSKYGY-SSNTVKLTFSEF---AK-F 120 Shewan...
2NRA_C                156 TTQLLTASLR-LSSQYSSSLYQLI-----RKHysn----------------fkkKNYFIISV-------D---------- 196 Escher...
EAY25477              136 NKFQLKNLLQ-LKGRHSKRLYMIL-----CAFq--------------------dTGWYYASI-------D---------- 172
Q7WWW9                151 SHFLSLRYVF--KSVHSKVLYDRLqqfmvEGI----------------------TPW--FEV-------Q---------- 187 Cupria...
Q6U5H5                126 CGLATKRVDSrLRKRFSDSLTRLQhthfqFIKnstvegkkvkidmslvstsyydEGTDEVIIrpnpdlnTlyrvdgktrl 205 Klebsi...
WP_011906524          118 CQYDSRQFNKrLRDTIFDALTRIGtktvqFNSkktgdkfft----qllksgkytKDTDTITLqaderlhElyqidynill 193 Entero...
Q71TA8                118 CGFPSKRLDAkLRLTIHESLGRLRnkgiaFKRgkdakggyqt---gllkvgrfdADLDLIELeadsklwElfqldyrvll 194 Escher...
Q6U5J6                126 CGFDSRRSNKkMRDRISNSLFKLAsvtlqFQSetkgwtth------lvqsayydINEDIVEIkaepklfElyhmdrrvll 199 Klebsi...
CAS07437              112 CGIPSSQSSRkLRERISPSLKRIAgtvisFSRttekhtkeyi--thlvqsayydTEKDIVQLqadprlfElyqfdrkvll 189
wugsc:KPN_pKPN4p07092 122 CGFSSKDKDKgLRTRLADSLIRLRsttikLASekdrngvvs----gllsrgkwdEKDDIMELtadeslwElyqfdrqvll 197
Q8E8A8                121 CSYPSRRFDKnLRKQIGDSLGRIQsqslsFRRknsekavht----gmllramydGEEDIVELmadetlwDlyrldyqvlv 196 Shewan...
2NRA_C                197 ELKE--------EL-IAytfdkdgniEYKYPDFPIFKRDVL-NKAIAEIKK--------KTEIsFVGFTVHek---egRK 255 Escher...
EAY25477              173 ELLN--------IFaSKvgedgqievKKYTAGS--LKKHIL-GKAKEE-----------IEDVtELRFEIEekk--sgRK 228
Q7WWW9                188 ALRA--------WLeCE---------KKTYDLFKHFRSKVL-EVAISE-----------IREVtGLHIEMLtlnvpgsKK 238 Cupria...
Q6U5H5                206 YLKIlktlsrkeSAqALylylvelpdHFYRIGFDRLRERLQlTSHKGAQNAtikkaleqLDEAgFLKYTIE-------KN 278 Klebsi...
WP_011906524          194 RKRPyhmlkgkeVAqTLytyiaslpdNPAPIRFDRIIERLNlTSPVKEQNRlikaalkqLHDIgYIEYSIV-------KD 266 Entero...
Q71TA8                195 QHHAlralpkkeAAqAIytfieslpqNPLPLSFARIRERLAlQSAVGEQNRiikkaieqLKTIgYLDCSIE-------KK 267 Escher...
Q6U5J6                200 RLKAidalqrkeSAqALytyieslpqNPAPISMKRMRDRLNlTSNVYTQNHtvrkameqLRDIgYLDYTEF-------KR 272 Klebsi...
CAS07437              190 QLKAinalkrreSAqALytfieslprDPAPISLARLRARLNlKSPVFSQNQtvrrameqLREIgYLDYTEI-------QR 262
wugsc:KPN_pKPN4p07092 198 QMFIirqlankgTAqALytfieslpeRPIPLSFARIKRRLMlTSPNNQQNRvinkaideLKAVgYLDGDVV-------KK 270
Q8E8A8                197 SLRVleklpraeVAqCLylyftslpeNPHPVSFERLRERLRlETSKKEANRkiktgiqkLESIgYLSGSFA-------VK 269 Shewan...
2NRA_C                256 --ISKLKFEF 263 Escherichia coli
EAY25477              229 --VVGYKFNI 236
Q7WWW9                239 --IGQVRFRL 246 Cupriavidus necator
Q6U5H5                279 --RGDYVLVI 286 Klebsiella pneumoniae
WP_011906524          267 grTLTVLIHK 276 Enterobacteriaceae
Q71TA8                268 g-RESFVIVH 276 Escherichia virus P1
Q6U5J6                273 --GRATYFSV 280 Klebsiella pneumoniae
CAS07437              263 --GRTKLFCI 270
wugsc:KPN_pKPN4p07092 271 dgEWHLIITR 280
Q8E8A8                270 ---NGEQYYL 276 Shewanella oneidensis
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