5A6W,7NLJ,6FUB,6FUD,6R8M,7B1I,7BNT,7A8W,7NMM


Conserved Protein Domain Family
AVR-Pik_HID
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cd23000: AVR-Pik_HID 
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HMA interaction domain found in Pyricularia oryzae AVR-Pik and similar proteins
Microbial plant pathogens secrete effector proteins that can be recognized by plant intracellular nucleotide-binding leucine-rich repeat (NLR) receptors, initiating an immune response. AVR-Pik protein is an effector from the rice blast fungus Pyricularia oryzae (also known as Magnaporthe oryzae). It binds and stabilizes rice heavy metal-associated (HMA)-domain containing NLR proteins to co-opt their function to suppress immunity. AVR-Pik adopts a six-stranded beta-sandwich structure. There are four AVR-Pik alleles, AVR-PikA, AVR-PikC, AVR-PikD, AVR-PikE.
Links
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Statistics
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PSSM-Id: 439386
Aligned: 13 rows
Threshold Bit Score: 110.605
Created: 15-Oct-2021
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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HMA domain
Conserved site includes 14 residues -Click on image for an interactive view with Cn3D
Feature 1:HMA domain interaction site [polypeptide binding site]
Evidence:
  • Structure:5A6W: Pyricularia oryzae Avr-pik protein in complex with HMA domain of Pikp1 from rice (Oryza sativa); contacts at 4A
  • Structure:7NLJ: Pyricularia oryzae APikL2A in complex with host target sHMA25 from Setaria italica; contacts at 4A
  • Structure:6FUB: Pyricularia oryzae AVR-Pik protein in complex with the HMA domain of Pikm-1 from rice (Oryza sativa); contacts at 4A
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1          #  # # #  #                                      # #    #  # ####    #        
5A6W_C        17 RERDPNFFDHPGIPVPECFWFMFKNn------------------------VRQDAGTCYSSWKMDMKVGPNWVH-IKSDD 71  Pyricularia oryzae
7NLJ_B        17 RERAPNFVDHPGIPPSDCFWFLYKNy------------------------VRQDAGVCQSDWSFDMKIGQYWVT-IHTDE 71  Pyricularia ory...
6FUB_B        17 RERDPNFFDNPGIPVPECFWFMFKNn------------------------VRQDAGTCYSSWKMDMKVGPNWVH-IKSDD 71  Pyricularia oryzae
6FUD_B        17 RERDPNFFDNADIPVPECFWFMFKNn------------------------VRQDAGTCYSSWKMDMKVGPNWVH-IKSDD 71  Pyricularia oryzae
6R8M_C        16 RERDPNFFDNPGIPVPECFWFMFKNn------------------------VRQDAGTCYSSWKMDMKVGPNWVH-IKSDD 70  Pyricularia oryzae
7B1I_C        18 RERDPNFFDNADIPVPECFWFMFKNn------------------------VRQDAGTCYSSWKMDKKVGPNWVH-IKSDD 72  Pyricularia oryzae
7BNT_C        18 RERDPNFFDHPGIPVPECFWFMFKNn------------------------VRQDAGTCYSSWKMDMKVGPNWVH-IKSDD 72  Pyricularia oryzae
7A8W_CCC      17 RERDPNFFDNPGIPVPECFWFMFKNn------------------------VRQDDGTCYSSWKMDMKVGPNWVH-IKSDD 71  Pyricularia ory...
7NMM_I        19 RERAPNFVDHPGIPPSDCFWFLYKNy------------------------VRQNAGVCQSDWSFDMKIGQYWVT-IHTDE 73  Pyricularia ory...
XP_029750031  37 REPDPNFIDHPGIPKPECFWFMFHDg------------------------QRVEAGTCYSNWEFGMQVGPSWVT-IQSDE 91  Pyricularia pen...
QBZ66555      37 REPDPNFIDHAGTPPAECFWFMYYNg------------------------QRIDAGTCYSAWSFGLKVGSSFVD-IKTDE 91  Pyricularia oryzae
QBZ58487     190 DYPDPPIDKHIDVAPGDCVWFWFEYaqpttkssdgwfrsgkkkptgpkqwIMRRSGDMCSDNSISMNVGLKGVItVTSDE 269 Pyricularia oryzae
TLD30795     145 HYDDPDVIDHAGQAPSDCFYFLFEYahptrtvkggwfkkdtkepmgpkkwILRDRGSQQSGNSLSYQLFPLDAI-FKTDD 223 Pyricularia sp....

Feature 1                           
5A6W_C        72 NCNLSGDFPpGWIVLGKKR 90  Pyricularia oryzae
7NLJ_B        72 GCRLSGIIPaGWLILGIKR 90  Pyricularia oryzae Y34
6FUB_B        72 NCNLSGDFPpGWIVLGKKR 90  Pyricularia oryzae
6FUD_B        72 NCNLSGDFPpGWIVLGKKR 90  Pyricularia oryzae
6R8M_C        71 NCNLSGDFPpGWIVLGKKR 89  Pyricularia oryzae
7B1I_C        73 NCNLSGDFPpGWIVLGKKR 91  Pyricularia oryzae
7BNT_C        73 NCNLSGDFPpGWIVLGKKR 91  Pyricularia oryzae
7A8W_CCC      72 NCNLSGDFPpGWIVLGKKR 90  Pyricularia oryzae 70-15
7NMM_I        74 GCRLSGIIPaGWLILGMKR 92  Pyricularia oryzae B157
XP_029750031  92 HCNLLGTYTpGWMVLGKKR 110 Pyricularia pennisetigena
QBZ66555      92 DCNLYGTYApGWIVLGKKR 110 Pyricularia oryzae
QBZ58487     270 RCDISGDFPtGWTVVGRKR 288 Pyricularia oryzae
TLD30795     224 DCNVKANLPsNWWVVGRKR 242 Pyricularia sp. CBS 133598

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