Conserved Protein Domain Family
bHLH_TS_dAS-C_like

cd19744: bHLH_TS_dAS-C_like

basic helix-loop-helix (bHLH) domain found in Drosophila melanogaster achaete-scute complex (AS-C) proteins and similar proteins

Drosophila melanogaster AS-C proteins includes lethal of scute (also known as achaete-scute complex protein T3 or AST3), scute (also known as achaete-scute complex protein T4 or AST4), achaete (also known as achaete-scute complex protein T5 or AST5), and asense (also known as achaete-scute complex protein T8 or AST8). They are involved in the determination of the neuronal precursors in the peripheral nervous system and the central nervous system, as well as in sex determination and dosage compensation.

Links

Source:	cd19723
Taxonomy:	Ecdysozoa
PubMed:	8 links

Protein:	Representatives
	Specific Protein
	Related Protein
	Related Structure
	Architectures
Superfamily:	cl00081

Statistics

PSSM-Id:	381587
Aligned:	6 rows
Threshold Bit Score:	76.8601
Created:	6-Aug-2018
Updated:	2-Oct-2020

Structure

Conserved Features/Sites?
PubMed References ?

putative DNAputative dimer

Feature 1:putative DNA binding site [nucleic acid binding site]

Evidence:

Comment:The N-terminal basic region of bHLH mediates high-affinity DNA-binding to specific hexanucleotide sequences
Comment:Based on the structure evidence that Mus musculus myoD (1MDY) basic region binds DNA.
Citation:PMID 8181063

Scroll to Sequence Alignment Display

Sequence Alignment

include consensus sequence

Format: Row Display: Color Bits: Type Selection:

Feature 1      #   # ### #    #                                    ####                  
P09774     84 SVARRNARERNRVKQVNNGFVNLRQHLPQtvvnsls---------nggrgssKKLSKVDTLRIAVEYIRGLQDML 149 fruit fly
P10083     25 SVIRRNARERNRVKQVNNGFSQLRQHIPAaviadlsng-----rrgigpganKKLSKVSTLKMAVEYIRRLQKVL 94  fruit fly
EFX72751   82 SVARRNARERNRVKQVNMGFAVLRQHIPTsfceastasdsgrsssgggssksRKVSKVDTLRCAVEYIRSLQEML 156 common water flea
P10084    100 SVQRRNARERNRVKQVNNSFARLRQHIPQsiitdltk--------gggrgphKKISKVDTLRIAVEYIRRLQDLV 166 fruit fly
P09775    160 AVARRNARERNRVKQVNNGFALLREKIPEevseafea-------qgagrgasKKLSKVETLRMAVEYIRSLEKLL 227 fruit fly
KRY38273   28 QVARRNARERNRVRQVNMGFVILRDHIPHyg-------------------knKKLSKVETLRAAANYIQHLQNLL 83  Trichinella spiralis

Citing CDD

Jiyao W et al.(2023). "The conserved domain database in 2023.", Nucleic Acids Res. 51(D1):D384-D388.

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Conserved Protein Domain FamilybHLH_TS_dAS-C_like

Conserved Protein Domain Family
bHLH_TS_dAS-C_like