Conserved Protein Domain Family
TMEM108

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pfam15759: TMEM108 
TMEM108 family
This family of proteins is found in eukaryotes. Proteins in this family are typically between 258 and 575 amino acids in length.
Statistics
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PSSM-Id: 464851
Aligned: 6 rows
Threshold Bit Score: 547.746
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EGW05644      14 VMTRNPKPD-----GPsSQAAATMETTvSHPEGYPPTDTVSTV-VT---AAIPHPESPLPTGSPPAAM--ATTASHSEGR 82 
EHB11476     104 VVTLGPAPD-----GP-SQATATMATTiPHQDRHPPINTTSTViVT---ANIPHSESPLPTGSPPVTM--ATIASHSESR 172
XP_003789447  63 LVTLTPHPD-----GPsSQATAPMGTT-ALPDGHPPTDSVSTIvAT---ATSPHSERPLPTGPPPMAM--TTTTSHSEGR 131
XP_005634500  61 VVTLTPHPD-----GPsSQATAPMAMTtPHPDGHPPTNTISTItVT---ATTPHSEGPLPTEPLPAAM--ATTSSYSEGH 130
XP_005162650  13 YSPLENHEHcgggaGPhDTMKRSLQVL--------PHQLLSILlIL---FV-------------PAGLvfSTEELHP--- 65 
XP_023394610 162 ptilltkptgitshppgeaiptvlltkpagvtsHPPGEAAPTIlLTkptEVTSHPPGEAL----PTIL--MTKSTGVTNH 235 African savanna...
EGW05644      83 PPGDATPTILPTKPAGATSRPTMSP-RSTTRRAPRPPGSSRKGASGSSRPLLPVPSGHSARKEGQRGRNQSSTHLGQ--- 158
EHB11476     173 PPGDAAPTILLTKPTGTTSHPTTAApRAITRRPPRLPGSSRKGTGASLRPVPPAPGGHSGRKEGQRGRNQSSTHLGQ--- 249
XP_003789447 132 PPGEATPTILLTKPPRATSHPTTASpRAATRRIPRPPGSSRKGAGSSARPVPPVPGGHAGRKEGQRGRNQSSTHLGQ--- 208
XP_005634500 131 TQGEAVPTILLTKPTATTSRPTTAPtRATTRRPPRPPGSSRKGANSSSRSVLPAPSGHSGRKEGQRGRNQSSTHLGQ--- 207
XP_005162650  66 ---------------------------S------QPPR-DLVSMSTSSRTLSP---GLLSWQEGSSTGNLHNQALASlea 108
XP_023394610 236 PPGEVVPTILLTKPMGATSRTTTAPtRSTTRRPPRPPGSSRKGAGSSSRPVSPASSGPLGRKESQRGRNQSSTHqGQ--- 312 African savanna...
EGW05644     159 -KRPLG-KIFQIYKGNFTGSV-----------------------------EpdpsalSPrtplwgYSSSPQPQTVSPATA 207
EHB11476     250 -KRPLG-KIFQIYKGNFTGSL-----------------------------E------TP------YFSLPQPQTVAATTA 286
XP_003789447 209 -KRPLG-KIFQIYKGNFTGSM-----------------------------EpepsalTPrtplwgYPSSPQPRTVTTTTA 257
XP_005634500 208 -KRPLG-KIFQIYKGNFTGSV-----------------------------EpdpstlTSrnplwgYSSLPQPQTVATTMA 256
XP_005162650 109 iRRPTAvDFFQTPKTTVPSAIvqtttvgvhhfapreqaqpgiplnkaevpEltpgsiFSrtnskvFSTRTQDQNFSTNTD 188
XP_023394610 313 -KRPLG-KIFQIYKGNFTGSV-----------------------------EpdpfalTPrnplqdYSSSPQTQTVAATTV 361 African savanna...
EGW05644     208 LRSTSWVPPTTSLVPAK-------DKPGL----IRANQGSGPTFTSAAGEPDA--TAASGAPAST-QPAPVPSQ----SP 269
EHB11476     287 PRSTSWVPPTTLLVPAE-------DKPGL----STADQGGGSIFTSPGRELNT--TAAAGAPISS-QATPVPSQ----HP 348
XP_003789447 258 PSSTLWAPPTTPLVPAE-------DKPGL----HTATPGGGSTITSRRGEPDT--TAASGAPASP-RPAPVPSQ----RP 319
XP_005634500 257 PSRTSWAPPTNPLVPTE-------DKPGL----SRAGQGDGSTFTSQGGELDT--TVASGAPASP-QPAPVPSQ----HP 318
XP_005162650 189 KPSTISRKPVNQFEPSGllrtnqiSTPGLvsgqRATNSGSGHSFVS-GTEHDVadTEKMSKPIDPiQHQSSPSSfslfKA 267
XP_023394610 362 PNSTRGIIH-HPLVPVE-------TKPGL----SRADQGGGPTFTSQGGELNA--TAASGAPSSP-QPAPVPSQ----RH 422 African savanna...
EGW05644     270 H-GDVQDSPSHSDSW----LAVTPDTDRPLSASSRVFtaatxxxxxxxxxxxxxxxxxxxsmfcTAATGPTQAAFDTSVS 344
EHB11476     349 H-SDTQDSPSLSDSW----LTVTSVTNRPLSASSKVF---------------------------TAVIGPSQAAFNATVS 396
XP_003789447 320 H-SNAQGGPNHNDSW----LTVSPSTSRPLSASAEVF---------------------------TTTMGPTQAAFDASVS 367
XP_005634500 319 R-GDPQDGPSHSDSW----LTVTPGINRPPSTSSGVS---------------------------TATAGPTQAAFNASVS 366
XP_005162650 268 HrSQNVNKVSAQHTItlrsLSITENPTLPLDTVGGALa-------------------------qTYIQSPPPA-----LA 317
XP_023394610 423 H-SGPQDGPSHSNSL----LTVTTGTNRRLSASSGVF---------------------------TTATGPTQAAFDASVS 470 African savanna...
EGW05644     345 VPSQGIPQGTSATPQAPTWPSGVSESTVS--LAEEKAEASPTTTDRG-----PRALSTVLSTATGNFLNRLVPAGTWKPG 417
EHB11476     397 APSQGIPQGTSTTPQAPAHPPGVSESTVS--LAEEEAAASPFMTDRV-----PSPLSTVVSTATGNFLNRLVPAGTWKPG 469
XP_003789447 368 APSQGIPQGASTTPRAPTRPPGVSESTVS--PAREEATATIPVTDRV-----PSPLSTVVSTATGNFLNRLVPAGTWKPG 440
XP_005634500 367 APSKGTPQGTSSTSQAPSHPTEGSESTIS--QAKEEATATPTMTNRV-----PSPLSTVVSTATGNFLNRLVPAGTWKPG 439
XP_005162650 318 PPSNHISTESSNTVEVGTN--GTTNMTVEflISPTNATDVLNSTDSLrpaanDSDMSEVPSTDSGSFMNRQVPATTQGPW 395
XP_023394610 471 APSKGIPQGASTTPRAPTRPPGFSESTVS--QAEEEATATSSMTGRV-----PSPLSTVVSTATGNFLNRLVPAGTWKPG 543 African savanna...
EGW05644     418 TVGNISHVAEGDKPQHRATICLSKMDIVWVILAISVPISSCSVLLTVCCMRRRKkTANPENNLSYWNNAITMDYFNRHAV 497
EHB11476     470 TAANISHVAEGDKPHHRATICLSKMDIAWVILAISVPISSCSVLLTVCCMRRKK-TANPENNLSYWNNAITMDYFNRHAV 548
XP_003789447 441 TAGNISHVAEGDKPQHRATICLSKMDIAWVILAISVPISSCSVLLTVCCLRRKKkAANPEHSLSYWNNAITMDYFNRHAV 520
XP_005634500 440 TAGNISHVAEGDKPQHRATICLSKMDIAWVILAISVPISSCSVLLTVCCLRRKKkTANPENNLSYWNNAITMDYFNKHAV 519
XP_005162650 396 GSGNQSGPALG-PPHEKNTICLDKMDIVWLVLAISVPVSTCSVLLTVCCMRKKKkSASQENNLSYWNDAITMDYFTRHAV 474
XP_023394610 544 TVGNISHVAEGDKPQHRATICLSKMDIIWVILAISVPISSCSVLLTVCCMRRKKkTAKPENNLSYWNNAITMDYFNKHAV 623 African savanna...
EGW05644     498 ELPREIQSLETSEDQLSEPRSPANGDYRDTGMVLVNPFCQETLFVGNDQVSEI 550
EHB11476     549 ELPREIQSLETSEDQLSEPRSPANGDYRDTGMVLVNPFCQETLFVGNDQVSEI 601
XP_003789447 521 ELPREIQSLETSEDQLSEPRSPANGDYRDTGMVLVNPFCQETLFVGNDQVSEI 573
XP_005634500 520 ELPREIQSLETSEDQLSEPRSPANGDYRDTGMVLVNPFCQETLFVGNDQVSEI 572
XP_005162650 475 ELPREIQSLEAEE---QETCLPPNGDYSDSGVVLVNPFCQETLFINRDKASDI 524
XP_023394610 624 ELPREIQSLETSEDQLSEPCSPANGDYRDTGMVLVNPFCQETLFVGNDQVSEI 676 African savanna elephant
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