Conserved Protein Domain Family
4HBT_3

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pfam13622: 4HBT_3 
Thioesterase-like superfamily
This family contains a wide variety of enzymes, principally thioesterases. These enzymes are part of the Hotdog fold superfamily.
Statistics
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PSSM-Id: 463937
Aligned: 235 rows
Threshold Bit Score: 77.757
Created: 25-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_014171578          39 ARPPWHPPGArGiYGGSVVSMCLAAGQRTV-------------EpdFaphSCHCYFLLAGNAAiPILLHVERVRDGRSFA 105 
EEP82916              27 LRLEWCIGTV-P-HGGYITSAFLNVACTHMrlnhpt-rhngcaDp-M---TMHLTFLRRTEAG-PATFRVEDTKLGARTS 98  
WGS:ABKH:PAAG_07230   28 LAREWAVGNA-A-NGGYITAILYRLAITHFqnahpt-hhssqpRp-I---NMQLSFLRRSLVG-PAFLTVRDVKLGARIS 99  
GAD96031              27 LRDEWCIGAV-P-HGGYTTCVMAKLAKTHFahthpn-lstspaTp-I---SIQLSFLRRTDVG-PALLTVEDMKIGARTS 98  
XP_002379152          29 LRDEWCIGTV-P-HGGYTTAVIYRLALTHFahthpt-lydapaTp-I---SLQLSFLRRTAAG-PAILTVQDMKLGARTS 100 
EPS25953              26 LHRDWCIGTV-P-HGGYTAALLYNLALTHFahthpk-qydapaTp-I---SLQLSFLRRTAAG-PAILHVQDVKIGLRTS 97  
EED53099              27 LHQDWCIGNV-P-HGGYTTAILYRLTTTHFarsdaspyrskpvLp-I---SFQLSFVRATQVG-PATLSVQEVKLGARTS 99  
XP_661866            936 LQKSFCIGTV-P-HGGYTSAVLYRLALVHFatahpnlykgepaTp-I---SMHLTFLRRTAEG-PAKLRVHDMKLGKRTS 1008
EDO00963              26 LPSSFSFGPR-I-FGGLVMSMVQQTVKQYFaevhs---eynqaDv-L---GMQWQFFRLLFPS-AAKIDIKDIHLGKASS 95  
CCG83458              24 LLRPWCIGAV-P-HGGYLLSVLLNAAKEHSkllhk---dlkqtDp-I---QMSVAFIVKAQVG-SARVVVEELKIGRGYS 93  
XP_014171578         106 TRTVQARQ--------------RGRCIFTLTVSFARMP-------------PKDtstsmsttAPLhhavaMPT------S 152 
EEP82916              99 TLHITLSQtdk---------nggLREEVAAYITMSNFDteegps-mvtgfeL-T--------PKP-----EPGsggsapV 154 
WGS:ABKH:PAAG_07230  100 TIQVTMSQadssfp---tgsrgRKIDKVTGFVTISDPVseagvs-apcswtV-Y--------PPP-----PDSkapqfsP 161 
GAD96031              99 TIHVLLKQrst--------skkEEEVKVAGYITLSPAAaetgit-aetswtL-H--------PPP-----PLGss--gpV 153 
XP_002379152         101 TIHINLCQpsekk-----akkgELEIKVAGYITVSPSTaevgis-sntgwdL-Q--------PAA-----QPGtgpngsV 160 
EPS25953              98 TIHVQLLQpsek-------apdQLAVNVAGYITVSPPSaevgis-aptgwtP-Y--------PVP-----PPGslpngqV 155 
EED53099             100 TIQVTLSQdaa---------skgPQTKVVGYITVSPVEtdqkgpvvngnsiL-Y--------PNP-----PSGskpdggI 156 
XP_661866           1009 SLHVELLQpkdqaqsgteiderEMEVKVAGYITVSPASsevgvs-aktnweL-H--------PKP-----VSGsrsdggV 1073
EDO00963              96 TILVTVSQk--------------gKDCMMGFVTITNMLlsrgfs-fttswkLDP--------PPI-----Q--------A 139 
CCG83458              94 NYRLSLQQqdegg---------hwitcIHALIIMGSFArevgpvipttsyyV----------PRL-----EDC------P 143 
XP_014171578         153 rPLQpPAdWDd----------DGGIEPRLlRALGiaPVEqPVVAGpmhivgdvdalphRKKTQQWVRVRgrisaAGGRa- 221 
EEP82916             155 -DLA-KL-ARdgkdg-awsqfAVAFTSMR-TASK--QLE-IYTPKsle-------rvkRGFVEQWVRFK-----PYGSla 214 
WGS:ABKH:PAAG_07230  162 -GHN-GQ-LVpgsp---wkktILCYPEFR-RASS--NSE-FWEPVdprl------derRAITDQWARLR-----PNGPkg 220 
GAD96031             154 -NLR-AL-AAngrdg-nwiqiPAPFVQFR-RAAA--NIE-LYGPDpasfsp-etnagrRAIVDQWARFR-----PLGAdk 219 
XP_002379152         161 -NLA-AL-GQtgrdg-kwvllQPPYPKFR-RATL--QLE-LYGPDpalg--------kpkVIDQWSRFR-----PGGDre 219 
EPS25953             156 -DLA-AL-ARtghdg-awtklDPPYADFR-RAAS--QLE-LYGPGkgqtq---qqrtgTMAIDQWARFR-----PGGEas 219 
EED53099             157 -DFA-AL-AEtgrdg--ewtrfPTIPAM--AVSQ--HTE-LYGALpastv----qeriKTTVDQWARFR-----PGGQvp 217 
XP_661866           1074 -DFD-RL-SKtgrde-awarqDPPFAQFR-KATT--QVE-LYGIDpalk------krkNGIVDQWARLK-----PEGQlt 1134
EDO00963             140 -SVS-AL-AKdndprwisyqtPYHPESFR-RVQS--YLK-YFVPYem---------qePSIRDQWITWS-----NPQTt- 197 
CCG83458             144 -EM------------------EAVYSDFR-AVAK--NFK-YWEPKdv---------ksPAVENHWLEFK-----D-GRp- 184 
XP_014171578         222 ------AHLCALAYLSDRyFigTiCRLHRLWrlpfsvesvLGeddvgdekddddddtTtynqlvrsspslrqlirqhvea 295 
EEP82916             215 -----pWTNPALGFLVDM-F--P-MMLETFD---------SKpw-----------ekKqeq------------------- 246 
WGS:ABKH:PAAG_07230  221 g--lgrWTGEALAYLVDI-F--P-VALGNLE---------IMt-------------aKem-------------------- 252 
GAD96031             220 kplegrWTDDTIGFLVDM-F--P-MMLDGFD---------VIsts----------aqDptkgn---------------sp 261 
XP_002379152         220 ----arWTNEAVAFLVDM-F--P-MALGGLD---------QMas-----------asTpsq------------------- 252 
EPS25953             220 ----grWTDAAVVYLLDM-F--P-MALEGFD---------TMsa-----------taVakek-----------------g 254 
EED53099             218 ----arWTNEALMCLLDL-F--P-MALDRLG---------AMats----------awTstnd-----------------p 253 
XP_661866           1135 -----rWSNEAVVFLTDM-F--P-MALDGFD---------TMad-----------grEsgsa------------------ 1167
EDO00963             198 ------FTNETLGFVLDIsF--P-ILDNFYP---------EVstgg-------qaatVaagleqk-----------rere 241 
CCG83458             185 ------MDLLAMALITDL-M--TpLPLRVCD---------NE---------------R---------------------- 209 
XP_014171578         296 esgGVpleayrgrprLGMVV----SLDHTVYFHE-PdrvcAd---DWMLVEMDSPWANSGRGVVTQRIFSKDGMLLATCV 367 
EEP82916             247 kkeDGt--------rRFWYP----TVLLNVEFKKrL----PkegvQWLYSRVHTKTLHNGRMDLDIVVLDEAGDIVALSN 310 
WGS:ABKH:PAAG_07230  253 --gSEp---------PFWFP----TIVLHIDFKKpL----PkggvEWLYSRITTKVVRNGRTDIEVVVMDEQGDVVALAT 313 
GAD96031             262 nknQKap------rgTFWYP----TVTLNVDYKKrL----PaegvEWLYCRVQTKAVRNGRTDIDVTVLDESGDIVALST 327 
XP_002379152         253 elaEKt--------aRFWYP----TVTLNIDFKKrL----PaqgaEWLYSRIHTKVVRDGRTDLNVVILDEQGDVVALST 316 
EPS25953             255 epvPEsm-------aNFWYP----TVTLNIDMKKrL----PregvEWLYSRVVTKVVRDGRTDLEVTVLDEKGEVVALST 319 
EED53099             254 edrQDrs------pgPFWFP----TVSFNVDLKKsI----PnegaAWLHSRVVTQTLRAGRADLSVEIFDENGELIAISS 319 
XP_661866           1168 tggAGpt-------aKYWFP----TVSLSIDFKKrL----PpageEWLYSRVVTKEVRDGRTDLDVTILDAKGEIVALST 1232
EDO00963             242 agiTKvida---ssgSYRAPamitSLSTSIEIKKlL----PpegtKWLFLRAQAKEIKNGRMSMEVLVFDEHMELVALSQ 314 
CCG83458             210 ----G------------WYP----TLSLDLQFKQaP----Kpg-glYTYLQAESDSIHNGRFDITTRCFDADHKLIALAR 264 
XP_014171578         368 QEVRA 372 
EEP82916             311 HVALV 315 
WGS:ABKH:PAAG_07230  314 QLGLV 318 
GAD96031             328 QVGLV 332 
XP_002379152         317 QVGLV 321 
EPS25953             320 QVGLV 324 
EED53099             320 QVCMV 324 
XP_661866           1233 QIGLV 1237
EDO00963             315 QLCPI 319 
CCG83458             265 HSALM 269 
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