4FHM


Conserved Protein Domain Family
Nup160

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pfam11715: Nup160 
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Nucleoporin Nup120/160
Nup120 is conserved from fungi to plants to humans, and is homologous with the Nup160 of vertebrates. The nuclear core complex, or NPC, mediates macromolecular transport across the nuclear envelope. Deletion of the NUP120 gene causes clustering of NPCs at one side of the nuclear envelope, moderate nucleolar fragmentation and slower cell growth. The vertebrate NPC is estimated to contain between 30 and 60 different proteins. most of which are not known. Two important ones in creating the nucleoporin basket are Nup98 and Nup153, and Nup120, in conjunction with Nup 133, interacts with these two and itself plays a role in mRNA export. Nup160, Nup133, Nup96, and Nup107 are all targets of phosphorylation. The phosphorylation sites are clustered mainly at the N-terminal regions of these proteins, which are predicted to be natively disordered. The entire Nup107-160 sub-complex is stable throughout the cell cycle, thus it seems unlikely that phosphorylation affects interactions within the Nup107-160 sub-complex, but rather that it regulates the association of the sub-complex with the NPC and other proteins.
Statistics
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PSSM-Id: 432020
Aligned: 17 rows
Threshold Bit Score: 236.589
Created: 24-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4FHM_B            27 LWVPALENDSEDDSEaiet-------addNE-KLFKKECVAYDAGVYT---SNKSKGSQTLRWSi--FQNRTLT--IFDV 91   Schizosacc...
EAZ63899          22 ITLPLKYPSQNQEQN--------------TN-ERFHALLAETGAIIDL---SASQSYIDFVSWDl-lADLKTITlsPINS 82  
Q6C9U5            25 VEIDGSKLITKKVVDerkrk----lesddAE-EVFLRRYVSKEGQMFQ------SSTNGEFSVRf-fDESHIMEvtGVNH 92   Yarrowia l...
KIS72224          32 IAVPTPQHTGLEDE---------------PE-PINVAHHHAVDARLYFpsySSTDLDGGFALARv-vAGGRELQllWSNL 94  
Q9C811            28 ISVPSPSVSSSSIGAnssedne-cvqlplSE-DYASSSVIGEPSISFV--------------WRinkTSPNALE--LLQL 89   thale cress
jgi:OSTLU_27350   24 VVDVDAGVRASADDWraskr----hrgegGEtPSDGARGARGGGVVDS-------KTGDVIAWNvggEFGGDVC--VIKS 90  
Q9Z0W3            28 FTVCDIGTASAAFGTvk-----------ySE-SAGGFYYVESGKLFSI-------TRNRFIHWK---TSGDTLE--LVEE 83   house mouse
Q9VKJ3            28 VKINTGTQSTLQDLKtf--------------eTSGGYCYKNTKNVQTR---------NRFIYWR---TYQDVLE--LSEV 79   fruit fly
Q5BDZ2            23 IPIPTQTGSQNRARFaissltdlaepiakDE-DEFARRYIATQGSVYF---RKRNVYPRAFLWRv-vNESTVLEiqCVDL 97   Aspergillu...
Q0TZE8            28 FTLPASSLTTFGSRTaakrtvpperyadqDE-DAYTRRHLATDGSIYF---RQHHAYPRSLLWRv-lDNRRAIElqSVDL 102  Parastagon...
4FHM_B            92 SLNsk----kEPLSKFNVKIH----------------FPSNV---MKDGVAFSFSEHSD---TTIIYAITHARVLYYIRL 145  Schizosacc...
EAZ63899          83 SVKk------LELPLQNIQVT----------------LPHKIvssKSVSITYQSDQSGNedgYIIVDLVDENFLFVTLRF 140 
Q6C9U5            93 DRK-------------SVRIY----------------FPEGL---QNHCTCVTEKDG-----VLYIDSISNSFLLYSVKL 135  Yarrowia l...
KIS72224          95 KEStsaagpsSKVLTKQHSFSaslspklasepartflFPAPL---LPGLGMFVDPSSN----RLYVIAATTTGFLYRLEF 167 
Q9C811            90 SAK-------SGFPITGLRFV----------------FAQTL---SPFAFVYADEGGDSgrlVYFLYSLTPSGVVYVLKL 143  thale cress
jgi:OSTLU_27350   91 TRG------------WAVRVV----------------TPSAL---APSCACASDGER-----VDVVLATADGAFVVRVRV 134 
Q9Z0W3            84 SLD-------LNLLNNAVRLK----------------FQNYNi--LPGGVHVSETQN-H---VIILILTNQTVHRLILPH 134  house mouse
Q9VKJ3            80 SLD-------ISLQRNHLRLR----------------FTDSA----VLNVSLTEQGTS----VTLLVVTVSSVHRYVFPL 128  fruit fly
Q5BDZ2            98 TKGgi----eNHEYNITLRLD----------------FQDKI---LPSGVALADLEDHD---VLNLFVITASKELHTLAL 151  Aspergillu...
Q0TZE8           103 DHNag----dRFEANLTLVLQ----------------FPSPI---RPFCIALAESADRD---ALIIFGITTANDLYVLTI 156  Parastagon...
4FHM_B           146 S-KTWFQ---------LPDARLDD--DW--CLCYRPISF-LNQKPDLM-----------AAISTSEICVSFFNGGLTKII 199  Schizosacc...
EAZ63899         141 AlSDFIVan------nSSKFSLGNfdQW--GHISVPYSFeMRSDPYLV-----------KTVDPLKVIVSLKDGGFLIFK 201 
Q6C9U5           136 P-FALFN---------EDNTEHYDtsRF--FQQQEDYGI-RSRKPLLLk---------sLKGQSNELVLSLCDGGLMKLE 193  Yarrowia l...
KIS72224         168 SaPHLFH---------QAKLASNWssEYriQHIASSESViTASLRGAAnaa------qlYVVDSGLALVTCADGTIIKLS 232 
Q9C811           144 SnTLAYK-----------SGSVFPldHL--IHLDVRPYLnESRVTS-------------VAASPGFIFLGRSDGCV---- 193  thale cress
jgi:OSTLU_27350  135 R----------------LDGDFDDdgSYeaIVGRAPSSMsGVQRIG-------------ACGAAAAILCDASGCAIVRTD 185 
Q9Z0W3           135 P-SRMYRselv--tesQMQSIFTDigKV--DFRDPCNSQlIPSVPGLSpgsttsaawlsSDGEAL-FALPSASGGIFVLK 208  house mouse
Q9VKJ3           129 K-VAGQEggaaspedlLSQSIFYDvnDK----INDPSTYyVTDGFGTMpnaav--syltQDSQSAYFAVAYQSKLLLHVM 201  fruit fly
Q5BDZ2           152 R-PEFFR---------KPASIDQNisDW--CKSYIPAPL-AFSHPHRL-----------HASSPLELFISLDSGALLRLT 207  Aspergillu...
Q0TZE8           157 P-RDFFV---------NPAASEQDieGW--CKRSEPTLF-SGRIPYRL-----------VAVNVDELLVALDDGAICRIH 212  Parastagon...
4FHM_B           200 Lnp------kdASHYEQHIDDSSYLFSLKKYLS--LQAFkaDYRSPNTIISMIFLS------TYNVLVMLSLDYKLKVLD 265  Schizosacc...
EAZ63899         202 Rsa------ilEDVEVGTFSEASSILPFTFLSGifKKDP--RQEVVLEGISSNTIVdvi-qiDSNTIASLTVRKVLKLWS 272 
Q6C9U5           194 Rqe------knGLFLTSLFSDPSYLTSLKDRFFs------kDKIASMPHLSIHAIIsm--tnFENHLLTVSVNQTLKKWD 259  Yarrowia l...
KIS72224         233 RsasgskdnndGAWKETVLRPTSFLSGVSRFFGr-SNAIseSESSPSFALSLDVYPge---vGNTMAFAASRDRKLRVWN 308 
Q9C811           194 ----------------SCFQPIVYFQKSSGFHQelRDDTgfGRLGTVVAAVQDLFIse--vhGRNYLCVLHADGALRVWD 255  thale cress
jgi:OSTLU_27350  186 R-----------------------LTTVCELQTstLSRVwnTIKGSSGQAVVDVTPrcvrvgAKDLVATLSSDGFVQVWD 242 
Q9Z0W3           209 Lpp------ydVPGIASVVELKQSSVMQRLLTGw-MPTAirGDHGPS-DRALSLAVhc--veHDAFIFALCQDHKLRMWS 278  house mouse
Q9VKJ3           202 Kcs------tgHTITHEIKEPKLMPWFLSNLKG--------ALTGRSETLEAATSMafseigGEIFILVLYRNNELRLWS 267  fruit fly
Q5BDZ2           208 Rraa----ddgSNWSPLTLDERTWGSSLRGLVRw-NAQSsiKYGGRT--LDTNVANavattsDQTYVFAVCLNHTLKIWN 280  Aspergillu...
Q0TZE8           213 Wdk------dtKAWDGSRYQHSNW--SVRGLLSw-KAQPtvRFEGAD--LAISAAAavtmspDRQHILSVCLDHTIRAWN 281  Parastagon...
4FHM_B           266 LSTNQCVET-IELSqt------------iLPLQSFPYLTSDHTTNSFIALY-----------------------Y---PD 306  Schizosacc...
EAZ63899         273 TDNLVPTSTpIELT---------------EINDSSSWLTSVPAKYFQVISSktgqs-------------ylslyYstnSA 324 
Q6C9U5           260 LNTLTGTEIkFDSD----------------------KSKLDTEPVTRVCASgeff----------------itfC----- 296  Yarrowia l...
KIS72224         309 LLTDSCIRT-IDLPlqmdspvsnetrlviATDESSSATEGSDTLAYFSSVSrpfvkvfapsrddrdghalyvlvYvpaSP 387 
Q9C811           256 ILTYSRVLC-QSIAakn----------leGVMCVRLWLGKADYDSGIIPLAv---------------------lY---RK 300  thale cress
jgi:OSTLU_27350  243 VTNAIHASQaRTTDgslk--------patAKVSRVCGSHLPPAPGTKTPAPdrvat------------------sfacAP 296 
Q9Z0W3           279 YKDQMCLMV-ADMLe-------------yVPVNKDLRLTAGTGHKLRLAYSpsmgl-------------ylgiyM---HA 328  house mouse
Q9VKJ3           268 VDNLQTVAS-INCSt-------------eLGQDSAAQ---GPQNSQLRKISdqnf----------------clfL---SH 311  fruit fly
Q5BDZ2           281 LATNKLVAT-KDLLgr-----------emQQ-NSLTY-SLNPAESSFIRVFnveraldg-------gyryyavtY---SP 336  Aspergillu...
Q0TZE8           282 VVSGKLGAH-MDLLgqt---------draLEKSGSSY-FIGPSQSTLMAVIpgppdgpasg---lggaqyflltY---SP 344  Parastagon...
4FHM_B           307 NSHGS---FSIYK-LNANAH----SFKLNVVIEKgiipPSLPDDefipw---mlsdFQLISSegsqSKFLLI-------- 367  Schizosacc...
EAZ63899         325 DNSKSryvFKTWK-IRKSDTiv-eLELLDHLTFQ----PELPNI------------LLLSSSaqpsFQNTLWfiqdyqtq 386 
Q6C9U5           297 --GET---IYFWD-----------QNFVQVFS------SKIPDIglws-----lkdMAFRQNe---GQFEVS-------- 338  Yarrowia l...
KIS72224         388 PSGNF---FSLYG-VELEDSkgssGGLGEVTLLWqkrcDAETRGrnve-----lrdVVFTPQgehgDGWVMW-------- 450 
Q9C811           301 SMNDS---MDVIT-----------VYGLHFSSAEgialSLDSGLqnipleegelrdVRFTSD-------KIW-------- 351  thale cress
jgi:OSTLU_27350  297 SEKGL---TLNVV-VSSRLApv-eADDEAAAATTtietAADAATlafyt--vkhgaLAFGSSiegsKGVARA-------- 361 
Q9Z0W3           329 PKRGQ---FCVFQlVSTENNryslDHISSLFTSQetl-----------------vdFALTST-------DIW-------- 373  house mouse
Q9VKJ3           312 NSRAE---FICVS-IMPDADda---sVINLVQNM----VPAPQTdl--------vdFDATSS-------HIW-------- 357  fruit fly
Q5BDZ2           337 FEDGC---FKFWA-IKGGLTt--pLEIEDLFPAAtl-rPLDPDStgnmf--wsiadFQVKPAee-gKRMELW-------- 398  Aspergillu...
Q0TZE8           345 -KQHQ---FKLWG-VRDADDa--qHGLYDVCEDAel-iPPIDELmdttv--wtleeFHIVPGpagwRGTELW-------- 406  Parastagon...
4FHM_B           368 ---------IAWKSNLNTV--------IQKCNLSLDQDESF--------------SCVWsh---sLDSFSLIEKTFFDVP 413  Schizosacc...
EAZ63899         387 lsddsikfhILWKSNTSSV--------LVTLAINFQTGAIE--------------SKKW------SHSQEGKTFEELGPY 438 
Q6C9U5           339 ---------TVWMSGVSHV--------VKKATVNRNG------------------DIQWse---cGTPLRMLPPLTVHDY 380  Yarrowia l...
KIS72224         451 ---------ALWDGGVGPV--------LKYAKVGVEAANADessisirsmaedlsKDDWrt----vSSERIYRPLHGEDF 509 
Q9C811           352 ---------TLKANELTSYmlcqksstMEAQSYTLQEDYIS--------------EQLFlssrssSHDLLLTTHSLFSSA 408  thale cress
jgi:OSTLU_27350  362 ---------LALTPDS-----------VVAALENFDDDDASsts--------tstLLSWp----lDALHRARDLRCGDVE 409 
Q9Z0W3           374 ---------ALWHDAENQ---------TIVKYINFEHNV----------------AGQWnp---vFMQPLPEEEIVIRDD 416  house mouse
Q9VKJ3           358 ---------ALWSNAEGD---------FHVSAAYFASNN----------------AIKWvs----aALEPPPDRYCLTME 399  fruit fly
Q5BDZ2           399 ---------VLWRNSGLYQ--------LYTLHFNFESLVSDw-------------ANNWtt---aASDTRRQELPPPLPI 445  Aspergillu...
Q0TZE8           407 ---------IRARSGPSSR--------IYSLKFDPSDDADTlta---------swKNDWes---vDAGLLTLDSLKSNPA 457  Parastagon...
4FHM_B           414 TNMSSgdi--------seiWLQHIFAHNT-SIESIQVAL--LSFQnsssqvsknkldKFGALTISELKNAVLSSIVSTIq 482  Schizosacc...
EAZ63899         439 HDSEY--------------YRNKILNSGRyNDLILQTSL--DVFR------------SYKGLDSVDKKSFIRDSTEETI- 489 
Q6C9U5           381 ERAVS-----------------------LySVPLLKAAL--SIFSrh---------gGGGNTISEAISSQLRLYTN---- 422  Yarrowia l...
KIS72224         510 EATLEatkevv---daadiFLDRVLEPGRfSEATLRLAL--STYKevpm-----ssnHPPSTLFASLRDEVASVVASNCq 579 
Q9C811           409 KDQIMgfi--------ssiFLRRLLCPGIfHNVALRLTL--LDHNknw------tdsEFQSLSLDELTSEILLLVEHEV- 471  thale cress
jgi:OSTLU_27350  410 ANVLAewghagrgngaaveLLRRFGKLNGyTAASVANSLasEIALrglss--elalqNTCDELGLDEAKTASDALVAAA- 486 
Q9Z0W3           417 QDPREm-------------YLRSLFTPGHfINAALCKAL--QIFCrg--------teRNLDLSWNELKKEITLAVENELq 473  house mouse
Q9VKJ3           400 QGVDPre-----------tYCSYIFHPGRfDRNVIAKAL--YMFRrvn------lqfDVKQLSMSVLKEQVCQAVEDEIq 460  fruit fly
Q5BDZ2           446 SDVVDpt----------ekWLKFLLQPNRfPTEVLETSL--TIYQealk----plssSSTSKKSTPLVERLCSTFAATVs 509  Aspergillu...
Q0TZE8           458 NPSEQgldialgevdifqqWLDFLLYPGRfSIATLETAL--LILRrdl------driQTTKTAKGSLKERICSTITALAs 529  Parastagon...
4FHM_B           483 iepnsdLTGYDYYEYKRLLYneWERFAKLVAYLDHFGDEILSINF----------DPSNaVTY------INYANKVAFIR 546  Schizosacc...
EAZ63899         490 ------KLASNNDPYETKQN--WYKLETLCAEFKKLGEEDLAISL----------TNQA-TLL------TIQANGLGIFR 544 
Q6C9U5           423 ------HSGPDYTGYAKDQVeaWSKFEGICQELSRQASACIGSSL----------SGA--QIY------ILTGTGVSTIR 478  Yarrowia l...
KIS72224         580 lendprTGGPMYEKLYASRVreWMRFVGLAEQIETAARWPIGLSLpassfdgsrvSSEAnVPL------VISRDTIALPV 653 
Q9C811           472 ------TAETSISVFHW-----WKNFCTSYLHHWCSNNEPRTLLV------------QSdVIG------LVRNNSVSLFF 522  thale cress
jgi:OSTLU_27350  487 ------GANASIQRVVET----WCRVAPTYAREWSRAHAPMAFLL------------DTdASWssslvlLRAGDALGAIR 544 
Q9Z0W3           474 gs--vtEYEFSQDEFRTLQQefWCKFYACVLQYQEALSHPLALHL----------NPVTnMVC------LLKKGYLSFLV 535  house mouse
Q9VKJ3           461 ne--lkDFVVTDEEYLEISTrlWDRFYSCCEQYHIKLSEPTGLAV----------LGGMdAVC------LVRRQSFALLR 522  fruit fly
Q5BDZ2           510 lr-kfeDDDMDFSRYRSDTDskWRQFWQIADDLNKRRFEPLTLSY----------DVYYeTPW------VLLSDSCAVVR 572  Aspergillu...
Q0TZE8           530 h---tqGGNKDLNRFEEAVAqqWQAFYGLVKDLHKRRGESLSLAY----------DQQTgTPW------LLLSDHLSAIR 590  Parastagon...
4FHM_B           547 DPYLIESF 554  Schizosaccharomyces pombe 972h-
EAZ63899         545 PSHYFESF 552 
Q6C9U5           479 PSTELEKL 486  Yarrowia lipolytica
KIS72224         654 NEDEASVI 661 
Q9C811           523 RLENAEHS 530  thale cress
jgi:OSTLU_27350  545 AGDDVEES 552 
Q9Z0W3           536 PSSLVDHL 543  house mouse
Q9VKJ3           523 PCEVLEHL 530  fruit fly
Q5BDZ2           573 ECSSTELL 580  Aspergillus nidulans
Q0TZE8           591 SCSDAEIS 598  Parastagonospora nodorum SN15
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