1G8Y


Conserved Protein Domain Family
RepA_RSF1010_like
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cd01125: RepA_RSF1010_like 
Hexameric Replicative Helicase RepA of plasmid RSF1010 and related proteins
This family includes the homo-hexameric replicative helicase RepA encoded by plasmid RSF1010. RSF1010 is found in most Gram-negative bacteria and some Gram-positive bacteria . The RepA protein of Plasmid RSF1010 is a 5'-3' DNA helicase which can utilize ATP, dATP, GTP and dGTP (and CTP and dCTP to a lesser extent).
Links
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Statistics
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PSSM-Id: 410870
Aligned: 35 rows
Threshold Bit Score: 159.084
Created: 17-Aug-2020
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
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ATP binding
Conserved site includes 7 residues -Click on image for an interactive view with Cn3D
Feature 1:ATP binding site [chemical binding site]
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                 ####  #                                                             
1G8Y_A     30 GTVGALVSPGGAGKSMLALQLAAQIAggpdlle--vgelptgPVIYLPAEDpptAIHHRLHALgahlsae---------e 98  Escherichia coli
CBL21789   82 PGTYIFAGSPKLGKSFLMAQLAYHVStgtplwn---yttrkeTVLYLALEDdyrRLQERLYRMfgtest----------- 147 Ruminococcus obeum...
ABF13471   87 PGTYLFAGAPKVGKSFLMAQLAYHVStglplwd---ypvhkgTVLYLALEDdhrRLQGRLYRMfgtegt----------- 152 Arcanobacterium py...
EES53143  331 GSVGILGSRPKTGKSTFARCLAVAVAsgelfld--eletvhgDVIYLALEEnkrAVVRAFKMValkgfgmdea----rar 404 Leptospirillum fer...
CAZ88598  343 AGMLVFGGAPKVGKSDFLLAWLTHMAagaaflg--mhpprplRVFYLQAEVqyhYLRERVKEVripasrll-------da 413 Thiomonas sp. 3As
EGL48816  369 GHKMLIAGPSKAGKSFALIELSIALAegkewlg---wdceqgKVLYVNLELdrpSALHRFKDVydamglppt------nv 439 Streptococcus dysg...
EDZ38649  186 RTVGLIVAQEGTGKSFLALEVALAKAtghdmtg--igvtgpgGVVYFSKEDppeIIEERLQAIgplissddaf----gra 259 Leptospirillum sp....
NP_943565  28 GHVGMLIAAPNVGKSHLALCIAMEHAssmsllgm-saadkpvKTLVLSSEDgagVIQSRMKEKlanctatikselknnlh 106 Listonella anguill...
ABA04085  377 GHLTVLVAPPGAGKSTLGIALAVAGVtgrgeivg-etvhetiKAWVWNNEDdrnELRRRLAAImqqwnvapa-----dlr 450 Nitrobacter winogr...
YP_353286  64 RMLSGTISPGGLGKSSLALVDALAMAtgrkrlhswvhsreglRVWYWCGEDpveEISRRLEAAcihygisdd-----eig 138 Rhodobacter sphaer...

Feature 1                                                        #                            
1G8Y_A     99 rqavadGLLIQPLIGslpn----imapEWFDGLKRAae------grRLMVLDTLRRf----HIEEENASGPMAQVIGRME 164 Escherichia coli
CBL21789  148 -dnlyfSVSASQLGNgl---------dEQLARFVAEhk------dtKLIIIDTLQKvr--eVGGDNYSYANDYQIMARLK 209 Ruminococcus obeum...
ABF13471  153 -ndllfAVYAKQLGV------------GLEEQLKKFvreh---pdtKLIIIDTLQKir--eAGGDKYSYANDYEVVGKLK 214 Arcanobacterium py...
EES53143  405 evlshiGLITGPTPKdf---------pKKLADLVEKhq-------pVLIIVDTLIRl---lKLQDSNAYSETSAGLEPLL 465 Leptospirillum fer...
CAZ88598  414 rtnfvaTPQLRLVLDd-----------AGLAQVIPAianafggeppDIIAIDPIRNvfdggDAGGENDNGAMLFFLSQRV 482 Thiomonas sp. 3As
EGL48816  440 anidiwNLRGKTVPMdk--------laPKLIRRSLKkn-------yQAVIIDPIYKv----LTGDENSADQMAHFTNQFD 500 Streptococcus dysg...
EDZ38649  260 dnleivSLYGKPATLvsekt---mvneKLVRQIIKSgf------gkDLLIFDTLRKl----HDLEENSSGEMKVLLEIFD 326 Leptospirillum sp....
NP_943565 107 fltdlePIVIPPDSSvq--------eqTEHKQYLEQlkqt--fsefDLVIVDTVTE-----SIGRCEEVKHDRLIKNVFQ 171 Listonella anguill...
ABA04085  451 gklglnSGSERPLVIakatkdgavvrlPDIEAIIERvqa----egiGLLIVDPFVEt----HEVDENNNAQIKAVAAMWR 522 Nitrobacter winogr...
YP_353286 139 grlhvdSGRDQPIKIaaadregvkvakPVVAALVAQmra----rriDALIIDPFITc----HTVPENDNTAMNAVIDAWR 210 Rhodobacter sphaer...

Feature 1                      #                                                              
1G8Y_A    165 AIAADt---gCSIVFLHHASKgaammga--gdqqqasRGSSVLVDN----IRWQSYLSSmtsaeaeew------------ 223 Escherichia coli
CBL21789  210 SFADAh---gLCLLLVHHTRKqnadd------kfdmiSGTSGLLGA----ADGAFLLQKekrtgnaat------------ 264 Ruminococcus obeum...
ABF13471  215 RFADDc---gVCLLLVHHTRKqqadd------kfdmiSGTNGLAGA----ADGAFLLQKekrtdgnav------------ 269 Arcanobacterium py...
EES53143  466 HMAHEr---nIAVLLLHHTKKsdq----------gelLGSTGIAAS----ADVILTLGKkdgtrtlvaegrgvafepvtl 528 Leptospirillum fer...
CAZ88598  483 DRIRQavnpdAGVILAHHTKKlgkkqfe--edpfqalAGAGSLRGY----YSTGMLLFRpdeirttrqlifelrngagi- 555 Thiomonas sp. 3As
EGL48816  501 KVATEl---gCSVIYCHHHSKgsqggk----ksmdraSGSGVFARD----PDALIDLVElel------------------ 551 Streptococcus dysg...
EDZ38649  327 RIALEt---gAAVLLIHHTNKssnlngq--qgdqssaRGSNAIVGN----TRWSLHLETvksd----------------- 380 Leptospirillum sp....
NP_943565 172 SLAGEs---gASLLLVHHVNKde-------------iRGNQEITMAsgagLTSIMRLTKclftlkrnke----------- 224 Listonella anguill...
ABA04085  523 EVARRg---dCAVVIVHHTGKppsaspdawtgslsasRGASSLGGV----ARIMRTLFAmsqsdadkf------------ 583 Nitrobacter winogr...
YP_353286 211 DVANQt---nAAIELIHHANKagtgd------sindgRGGSAFRDG----IRAGRVLAPmtfeegekm------------ 265 Rhodobacter sphaer...

Feature 1                                                                                     
1G8Y_A    224 --------------------------------------gvdddqrrFFVRFGVSKanyg--------------------- 244 Escherichia coli
CBL21789  265 --------------------------------------levsgrdqQDQKLYLIRntetllwdlqkaetelwkeppepll 306 Ruminococcus obeum...
ABF13471  270 --------------------------------------ldvagrdqQDQRFYLTKdk----------------------- 288 Arcanobacterium py...
EES53143  529 sfhpdslfysmgvpvdeaeihvvmeriraswgitrtapfpgrifkpVWRAESKRKtrpsvgwnmrgsss----------- 597 Leptospirillum fer...
CAZ88598  556 ---------------------------pikhvdkiigewrevdandRLVMKDYGErl----------------------- 585 Thiomonas sp. 3As
EGL48816  552 --------------------------------------------tdELIKQRVEKa------------------------ 563 Streptococcus dysg...
EDZ38649  381 -------------------------------------------ageKRVKVTIPRasyg--------------------- 396 Leptospirillum sp....
NP_943565 225 -------------------------------------slsikylksNYLPENENQefavevr------------------ 249 Listonella anguill...
ABA04085  584 --------------------------------------gldaderrLWVRLDDAKanlsl-------------------- 605 Nitrobacter winogr...
YP_353286 266 -------------------------------------glapaeaarIFRAMDGAKtnmsa-------------------- 288 Rhodobacter sphaer...

Feature 1                                                                             
1G8Y_A    245 ----------------------------apfaDRWFRRHdg--------------------------gVLKP 262 Escherichia coli
CBL21789  307 deiaelvmkdnpywegsptalvalinvdiqphVITRKLN-----------------------------VLAG 349 Ruminococcus obeum A2-162
ABF13471  289 ------------------------------erLIWTLERteteaw-----------------teppdpVLEA 313 Arcanobacterium pyogenes
EES53143  598 -------------------greppdqrkipsiSSWFPKVptihrnqdtkmrkv-apvlagswfpkiqkILVP 649 Leptospirillum ferrodiazot...
CAZ88598  586 ------------------------------daERRRKRDailqilfdeaaaghcytanqfaesfegkaGLGG 627 Thiomonas sp. 3As
EGL48816  564 -------------------------------sAKVYQKAlqeqnlsy--------------yqhevtlDDLE 590 Streptococcus dysgalactiae...
EDZ38649  397 ----------------------------peggEWWLERTeg--------------------------gVLVQ 414 Leptospirillum sp. Group I...
NP_943565 250 --------------------------qgltinPQVFSLKskaskparsa----------qsikqspkkITLP 285 Listonella anguillarum 775
ABA04085  606 ----------------------------asgsARWFKRVsiiian------------------geevgALVP 631 Nitrobacter winogradskyi N...
YP_353286 289 ----------------------------rggaFTWYRMQs----------------------------VPLG 304 Rhodobacter sphaeroides 2.4.1

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