4F88,2VPM


Conserved Protein Domain Family
CHAP

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pfam05257: CHAP 
CHAP domain
This domain corresponds to an amidase function. Many of these proteins are involved in cell wall metabolism of bacteria. This domain is found at the N-terminus of Swiss:P43675, where it functions as a glutathionylspermidine amidase EC:3.5.1.78. This domain is found to be the catalytic domain of PlyCA. CHAP is the amidase domain of bifunctional Escherichia coli glutathionylspermidine synthetase/amidase, and it catalyzes the hydrolysis of Gsp (glutathionylspermidine) into glutathione and spermidine.
Statistics
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PSSM-Id: 461605
Aligned: 473 rows
Threshold Bit Score: 28.9269
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4F88_2                  323 QVGKYiGdgQCYAWVg--WWSARVCGysisystgdpmlpligdgmnahsihlGWDWsian-----tgiVN---------- 385 Stre...
jgi:Fluta_1291           65 YNIGLkY--QCVEFVk-rYYY--EHykhkmp----------------naygnAIDFfdkrlvdgqlnaERd--------- 114
EFC69584                 64 YNVGVrY--QCVEFVk-rYYY--LHyhhrmp----------------dtyghAKAFfdkklsngslntARa--------- 113
CAR66869                 65 YNLGIkY--QCVEFIk-rFYF--QFyhhkmp----------------dtyghAKDFfdhsvadgginkKRa--------- 114
EDP96477                 64 YNLGLeF--QCVEFVk-rYYY--EHlnhkmp----------------dsyghAKDFfnpkvkdgkrnvQRn--------- 113
jgi:Celal_2570           68 YNLGLkY--QCVEFVk-rYYY--DAlkhkmp----------------dsyghAKDFfnplvkdgelntQRn--------- 117
PRJNA433545:C4N18_01515  68 YNLGMkY--QCVEFIk-rYYF--EYYnhkmp----------------dtygnAKDFydnkl---kdaeMNvk-------r 116
jgi:Celly_1469           64 YNLGLkY--QCVEFVkryYYE--ELnhkmp-----------------dsyghAKDFf----------nSQikdgkinkqr 112
jgi:Sgly_2382            86 YYYGLkW--QCTEYVkrfYYTVYQHkmpd-------------------gagnAKYYfnpm----leqgEYnnq------r 134
WP_012425070             67 YYYGYkW--QCVEYIk-rFFY--EAKvhkmp----------------dvygnTKDFfdq------eleQCalne---krg 116 Clos...
4F88_2                  386 -YP----VGTVGrkedlrVGAiwcATAFSGAPfytgqYGHTGIIESWs-dTt--VTVLEQN 438 Streptococcus phage C1
jgi:Fluta_1291          115 -LIqytnPSKSKp----kVGD---LIIM-DATfs-neYGHVVIVSKVtt---deVEIIQQN 162
EFC69584                114 -LFqytnGDHVKp----qKGD---LLVF-DSYil-npYGHVAIVSRVt-dSn--IEIIQQN 161
CAR66869                115 -LLqftnGSISAp----eTGD---IIVF-SPTlf-nrYGHVAIVSAVep---tsIEIIQQN 162
EDP96477                114 -LIqytnKSISKp----kTND---IVVF-EASwy-nrFGHVAIVTEVs-eNt--VSIIQQN 161
jgi:Celal_2570          118 -LNqfinPSSAKp----rVND---LLVY-SGTll-nkYGHVAIISNVtanG---IEIIQQN 165
PRJNA433545:C4N18_01515 117 gLLqfsnPSFKKp----sVGD---IIIFKPSLln--pYGHVAIISKVde---saIEIIQQN 165
jgi:Celly_1469          113 nLKqyknPSKSKp----kVND---LVIYSATTln--kYGHVSIVSKVte---neVEIIQQN 161
jgi:Sgly_2382           135 gLFqyknGGDVKp----rEDD---LIVFTDGK-----YGHVAIISAT---GedwIEVVQQN 180
WP_012425070            117 lYQykngANEKPm-----KDD---LLVFTYTN-----YGHVVIISEV---GdnyIEVVQQN 161 Clostridium botulinum
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