1IK9


Conserved Protein Domain Family
DNA_ligase_IV
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pfam11411: DNA_ligase_IV 
DNA ligase IV
DNA ligase IV along with Xrcc4 functions in DNA non-homologous end joining. This process is required to mend double-strand breaks. Upon ligase binding to an Xrcc4 dimer, the helical tails unwind leading to a flat interaction surface.
Links
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Statistics
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PSSM-Id: 463272
Aligned: 14 rows
Threshold Bit Score: 55.7634
Created: 24-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
1IK9_C          3 TKEHFAREYDCYGDSYFIDTDLN-QLKEVFSGIKN 36   human
XP_002111010  749 TAEVFAKEYDKYGDSYTKDIDNPvALKAIFDKINN 783 
XP_005507867  755 TKEHFAREYDCYGDSYTADTDVA-QLKEVFSRMKD 788 
OCA46071      753 TAEHFACEYDCYGDSYITDTSEY-QLREVFHRMSN 786 
XP_006639224  799 TKQHFATEYDCFGDSYYADTDEK-ELKEVFSRISK 832 
XP_001647535  737 TTAKFREEYDRHGDSFTCDATAD-SLKTVFHNIAN 770 
EFA81882      864 TRDIFSKEIDPYGDSFTEDTDVQ-TLKDAFKQIER 897 
EGG24891      816 TKQLLLQDIDRFGDSFTQDTTVD-ELLDSFNQITK 849 
XP_003287084  898 TKKKFLLESDPFGDSYFNETNFS-ELKDCFNQVDK 931 
Q54CR9        924 TKKRFLLDSDQFGDSYINETTEQ-SLKDSFNQIDK 957  Dictyostelium discoideum
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