1UJ2


Conserved Protein Domain Family
UMPK
?
cd02023: UMPK 
Click on image for an interactive view with Cn3D
Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway, this enzyme combined with nucleoside diphosphate kinases further phosphorylates UMP and CMP to form UTP and CTP. This kinase also catalyzes the phosphorylation of several cytotoxic ribonucleoside analogs such as 5-flurrouridine and cyclopentenyl-cytidine.
Links
?
Statistics
?
PSSM-Id: 238981
Aligned: 34 rows
Threshold Bit Score: 173.51
Created: 18-Oct-2004
Updated: 2-Oct-2020
Structure
?
Program:
Drawing:
Aligned Rows:
Download Cn3D
Conserved Features/SitesClick to see Conserved Features Help
 
Conserved site includes 3 residues -Click on image for an interactive view with Cn3D
Feature 1:ATP-binding site [chemical binding site]
Evidence:
  • Structure:Residues in close contact with substrate ATP, in structure 1UJ2_B.
Download Cn3D for Viewing 3D StructureScroll to Sequence Alignment Display
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
Feature 1                 #                                                                   
1UJ2_B     24 LIGVSGGTASGKSSVCAKIvqllgqnevdyrqkqVVILSQDSFYrvLTSEQKAKALKGQFNFDHpdafdnelilktlkeI 103 human
AAQ66782    7 IIGVAGGSASGKSTLVKKLceaf-------veedVLVLCHDYYYkaNDHLSLEERKKLNYDHPNafdtdmf--vrdilsL 77  Porphyromonas ging...
Q8XJI6      6 FIGITGGTGSGKSTIAKEIyrqf-------gedcIAMIEQDSYYkdQSHLSMEDRVKTNYDHPNafdnnll--vshlesL 76  Clostridium perfri...
NP_242141   7 IIGVAGGTGSGKTTVAKEIfyqf-------neksIVLIEQDAYYkdQSQLSLEERLQTNYDHPLafdndll--iehlhsL 77  Bacillus haloduran...
P44533      8 IIAITGASASGKSSIASTVhkelcn---elgcqeIGIITEDSYYkdQSHLEMTERVKTNYDHPNsmdrdll--iqhlknL 82  Haemophilus influe...
AAP56798    8 IIAIAGGSGSGKTTITQSIiakiks----dtnlkVATVCLDNYYkpFSDLNLEARKKLNYDDPNsfdfdqv--yydllaL 81  Mycoplasma gallise...
Q9PQF9      8 LILIAGASGSGKTTFANEIiarip------knttSVVICQDSYYisNSQLNKKERRLINYDHPSsfewelm--reqlsdI 79  Ureaplasma parvum
P47622      7 LVAISGGSCSGKTTVAEMIyqlls------kklkVAIICQDNYYksYKNKPLLKRKTINFDHPDafdwkll--rshiedL 78  Mycoplasma genitalium
Q59190      4 IIGISGGSGSGKTTVVSKIsef---------ipeFVLISQDNYYksVGDYEHEFSKVNFDHPDAfdnnlf---yehlknL 71  Lyme disease spiro...
NP_968417   6 IIGVAGGSGSGKTYFAKELqkml-------gsenCSILYQDNYYidQSARFDGDGGSVNFDHPQaldftll--arglqtL 76  Bdellovibrio bacte...

Feature 1                                                                             #       
1UJ2_B    104 TEGKTVQIPVYDFVSHsrkeetvtvypadVVLFEGilafysq---------evrdlfqMKLFVDTDADTRLSRRVLRDIS 174 human
AAQ66782   78 KAGKTIERPVYSFVEHnrlqekvtvrpakVIVLDGilifenk---------elrdlmnVKVFVDTDADIRLARRLVRDVQ 148 Porphyromonas ging...
Q8XJI6     77 LNGHSIQKPSYDFSIHnriedttkvepkeIVIVEGililedp---------rirelldIKIYVDTDADVRIIRRMVRDIN 147 Clostridium perfri...
NP_242141  78 LNGQAIEKPVYDYKLHtr---------snEVILVEpkdviilegilllederlrelmdIKLFVDTDADIRIIRRMVRDIR 148 Bacillus haloduran...
P44533     83 KNGSAVDVPVYSYVEHtrtnetthftpkrIVILEGillltde---------rvrqladISVFVDTPLDICFIRRLQRDME 153 Haemophilus influe...
AAP56798   82 SNNQTIKMPIYDYKNYtrsdqfteidpsdVILYEGilslyds---------rildlskFKLFIDTPSDERLARRIERDCL 152 Mycoplasma gallise...
Q9PQF9     80 KKRKKIKVPIYDYKTEirldktidisdvdVIVLEGiyaiydd---------vinqiadLKIFIETPKDECLIRRILRDVN 150 Ureaplasma parvum
P47622     79 LNGSIVNVPLYDYINYtrakktakigpidVVILEGlmpwfde---------klsrlskLKIFIETNGEERLIRRIERDWQ 149 Mycoplasma genitalium
Q59190     72 KKNSPIDMPLYDFINHkrqlktvlvvptpVVIVEGimifvee---------rvrnlidLKIYIDTPNDIRFIRRLRRDIS 142 Lyme disease spiro...
NP_968417  77 KMGQPLQVPIYDFVTHsrktetllenpkkVIIVDGililhsk---------evraeldEAVFFDTPEDLRFQRRLHRDVH 147 Bdellovibrio bacte...

Feature 1                                             #               
1UJ2_B    175 ERGrdleqILSQYITFVKPAFeefclptkkyaDVIIPRGADNlVAINLIVQHIQDI 230 human
AAQ66782  149 ERGrnmdsVLAQYFSTVRPMHedfvepskryaDLIIPEGGFNsVALSLLVEKIRSV 204 Porphyromonas gingivalis W83
Q8XJI6    148 ERGrtmesVINQYLNVVKPMHnqfteptkkfaDIIIPEGGHNkVAIDIIVAKIKEV 203 Clostridium perfringens
NP_242141 149 ERGrtlesVIEQYTKVVRPMHmqfieptkryaDVIIPEGGQNrVAIDLMVTKIRAI 204 Bacillus halodurans C-125
P44533    154 ERGrslqsVIDQYRATVRPMFlqfiepskqyaDIVIPRGGKNrIAINMLKAQILHL 209 Haemophilus influenzae
AAP56798  153 ERArdikqVLNQWRSQVRVMHrkyvqkqkegaNLILPWYTLNhEGMSIIQNAIIKI 208 Mycoplasma gallisepticum R
Q9PQF9    151 ERNrsfesVITQWRSTVSPMYdqfvepskknaNVSVLWNEHNrVALHLIHKWINNI 206 Ureaplasma parvum
P47622    150 RGRnidsiIKQWREIVAPMYEifvek-mkrnaDLILPWSQRReVSTSVLDVAIEHL 204 Mycoplasma genitalium
Q59190    143 KRGrtvesVIDQYLNTTRWGYyrfieptkeyaDLIIPEGGHNdKALYVLSTFLKSL 198 Lyme disease spirochete
NP_968417 148 ERGrtpegVKKQFELQVRPMHdefvepskrhaQTIVTDSGDYhAVLSQFTHRLQNT 203 Bdellovibrio bacteriovorus HD100

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap