Conserved Protein Domain Family
FAM117

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pfam15388: FAM117 
Protein Family FAM117
This protein family is a domain of unknown function found in eukaryotes. Proteins in this family are typically between 269 and 453 amino acids in length. There are two conserved sequence motifs: RRT and TQT.
Statistics
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PSSM-Id: 464695
Aligned: 24 rows
Threshold Bit Score: 241.539
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_031821931  87 VRRTFSLDTILGSYLLGQWPRD-ADgtFTCYTNDKATQTPLSWHELEGEQTGSCTHKRSASWGSTDHRKE-ITKLKQQLQ 164
ELK04850      22 IRRTSSLDTLAAPYLAGHWPRD-SHgqAAPCMRDKATQTETAWAEEYSEKK-KGSHKRSASWGSTDQLKE-IAKLRQQLQ 98 
XP_007261123 296 IRRTSSLDALTGPYLSGHWPRDaTHapCGPCMRDKATQTPSAWLDESEEKR-RSCHQRSASWGSTDQLKE-ITKLRQQLQ 373
XP_002938763 127 IRRTSSLDTITGQYLTGHWPRD-PHvhYSSCMNDKSTQTPNCWGEEGATKK--SNHQRSASWSSADQLKE-IAKLRQQLQ 202
EDO41409     108 LRRTSSLDAISGTYLSGQWPRAnETssYGPLVCHKSTQTP-TWDESEIDEP-SYRPKRSNSWSSADHMRE---KLRQQ-- 180
NP_001073419 154 IRRTSSLGAITGPYLIGQWPRE-SHlhNPLCMKDKSTQTPGCWSDESEEK--RSTHQRSASWGSSDHLKE-IAKLRLQLQ 229 zebrafish
XP_007230934   1 MR-------------------------------DKATQTPRAWVDE---RR-RGSHKRSASCGSTDQLKE-IAKLRQQLQ 44  Mexican tetra
XP_003222709  56 VRRTSSLDNVLGSYLLGQWPRD-ADgaAIAHMSDKSTQTPVSWHDTGMGR--ATVHKRSASWSSVDHRRE-IAKLKQQLQ 131 green anole
XP_022538809 191 LRRTSSLGAITGPYLTGQWPRD-PH--YPSCMKDKSTQTPGCWSEETSEGELRSTHQRSASWGSADQLKEqIAKLRLQLQ 267 Mexican tetra
XP_014346814 173 IRRTFSLDAIVVPYLLGQWPCD-VDt-HYSCLNEKATQTPSAWLEAQKERSSACLHKRSASWGSTDHLRE-IAKLRQQLQ 249 coelacanth
XP_031821931 165 RTKLS--RNGKE--KERASPIQG-------DH-AVRGALR--------ASPPSFP---Sg-SPVLRLS-PCLHRSLEGLN 219
ELK04850      99 RSKHSs-RHHRD--KERQSPFHG-------NHaAI-NQCQap-----vPKSVLIP---V--IPITKSTgSRFRNSVEGLN 157
XP_007261123 374 RSKHIs-RHHRD--KERKSPFNG-------NH-VSINQSQap-----iPKSVLIP------IPISKSSvSRFRNSVEGLN 431
XP_002938763 203 RTKNSs-RLIKE--KDNQLPVQG-------NH-VAVTHTQgs-----aSRSIPVP---TtnISVPKSVgSRAACNVEGIS 263
EDO41409     181 RIKQGs-NRSPS--YGRQSPLHG-------DH-AIQKATQ--------SVAIPIP-------KITRSSeGHQRRSLEELN 234
NP_001073419 230 RNKQGggRQCKDs-KECLSPLHCctstttiTAtTISTASQapl---smSKSAQMP---LsnITVPKPSiSRVPSSMEGIN 302 zebrafish
XP_007230934  45 RSKRSs-RHRRD--KERKSPFNG-------NH-AI-IQSQsq-----mPKTILIP------IPISKSTpPRFRNSIEGLN 101 Mexican tetra
XP_003222709 132 RTKLGa-YHSKE--KDQSSPVQG-------DH-TVLSLAK------------ALPpasFpaLATVSVS-PCLHNSSDAIN 187 green anole
XP_022538809 268 RSKQGg-SRLSKdgRELLSPLHCcii-tttSHsTISTASQapflqspmSKPAQMP---LsnITVPKPSiSRVPSSMEGIN 342 Mexican tetra
XP_014346814 250 RSKLC----GRE--RERNSPIHG-------DH-ALLNTSQ-----------VPQP---VsvSPVGKLS-PRLHRSLEGLN 300 coelacanth
XP_031821931 220 QELEEVFVKEQGEEEl-LR--IL--DVPDGHRAPAP---------------------AQGVNSDSSLLPLEPgn------ 267
ELK04850     158 QEIE-IIIKETGEKEeq--liPQ--DIPDGHRAPPP---------------------LVQRSSSTRSIDTQTpgga---d 208
XP_007261123 432 QEIERIIIRDSGEKE--EQliPQ--DAPDGHRAPPP---------------------LCPRSASSRSIDTQTpsgim-ag 485
XP_002938763 264 PELEKVFIKETSEKDesVK--PV--EIPDGRRAPVP---------------------STCRSSSTRSIDTQTpsvh---e 315
EDO41409     235 TEIQKLVLRPGDDPAe-VK--LI--EPVDGRKAPIPdilsigspfptvdmhtqtqaeNQDSQESSRSHSASPcypimagt 309
NP_001073419 303 HELEKVFIKDNGEKEel---kAL--EVPDGRRAPFP---------------------PQQRSSSSRGIDTQTpsvp---g 353 zebrafish
XP_007230934 102 QEIERIIIRDTPERD--EV--IIpqDVPDGHRAPPP---------------------LPRRSSSTRSIDTQTpsgg--gl 154 Mexican tetra
XP_003222709 188 QELEEVFVKEQGDEEl-LR--IL--DVPDGHRAPVP---------------------LQGATRDSLLLPVEH-------- 233 green anole
XP_022538809 343 HELEKVFIKDNGEKEe-LK--AL--EVPDGRRAPFP---------------------PQQRSSSSRSVDTQTpsv----p 392 Mexican tetra
XP_014346814 301 QELEEMFVREQGDKEl-FR--IL--DVPDGHRAPVP---------------------SQRCCSNSQSDPFSVsltlrrns 354 coelacanth
XP_031821931 268 lsLS---P---SLPLasPQstgqASRFEPQAate--------------elTPNPKEKAssppravqvedDGPSPvLAFaS 327
ELK04850     209 rgSN---Ns-sRSQSvsPTsfltISNEGSEE-------------------SPCSADDLlidpr--dkenGNNSPlPKYaT 263
XP_007261123 486 snHS---NsssRSQSvsPAfl-tVPSEPCSEspspn----------eeplSDCRDKDL-----------APGSPlPKYaS 540
XP_002938763 316 rsSS---CssnHSPCasPS----CPHESQEGspc--------------saDDLLFDRDkd--------sGSSSPlPKYaS 366
EDO41409     310 tdSK---PpsrCSSGegPTmtdsAPTDGSNGien--------------asADESTIDP--------------PSsQKYaS 358
NP_001073419 354 rsSS---Cs-sLSPCpsPA----CPPRSHDG-------------------SPYSTDEMlddr---dkdsGSSSPlPKFaS 403 zebrafish
XP_007230934 155 gnRS---NsssRADSvsPSylsiLNDMGNSPlpn--------------ddTLSESREKd---------lGPYSPlPKYaS 208 Mexican tetra
XP_003222709 234 --SSsscSslsLSPS---------PSSTHRRsphtpartaaeehspgvieKPLLEAKAke--------nSSTSPvLAFaL 294 green anole
XP_022538809 393 grSS---ScssLSPCpsPA----CPPGSHDG-------------------SPYSTDELledr---dkdsGSSSPlPKFaS 443 Mexican tetra
XP_014346814 355 dcSS---L----SPTt-PLs--pHPFSQETPeecs-----------sedtGSEGMNEv----------sDCCCPiPKFsA 403 coelacanth
XP_031821931 328 SPRPNHSYVFKREPPEGCEKVRAFeEA-PSLSPDLT-FLPSCPDKNKVHFNP-TGSAFCPVSLVKPLFPSMGFLF 399
ELK04850     264 SPKPNNSYMFKREPPEGCERVKVF-EE-CSPKQLHEiPAFYCPDKNKVNFIPkSGSAFCLVSILKPLLPTPDLTL 336
XP_007261123 541 SPKPNNSYMFKREPPEGCERVKVFtEE-TQARPPQEiPQFLCPDRNKVNFVPkSGSAFCLVSILKPLLPASELNL 614
XP_002938763 367 SPKPNNSYMFKREPPEGCERVKVF-EE-LSTRPPVSsALFSCPDKNKVNFIP-TGSAFCPVKLLGPLLPASDLTL 438
EDO41409     359 SPKPNKSYTFAREPPDGAEKVPLYvED-NESFEKPS---FTGPDKTKVKIIFsNGSAFSAL----PSIPKMAITP 425
NP_001073419 404 SPKPNNSYMFKREPPEGCEKIKVF-EE-MTSRQSTTvPLFSCPDKNKVNFIP-TGSAFCPVKLPGSMLQHSSSQQ 475 zebrafish
XP_007230934 209 SPKPNNSYMFKREPPEGCEKVKVFeENqPRPLQEIP--PYLCPDRNKVNFIPkSGSAFCLVSILKPLLPTQELSF 281 Mexican tetra
XP_003222709 295 SPRPNHTYVFKREPPEGCEKVRAFeEV-VPLSPDQP-FQPSCPDKNKVHFNP-TGSAFCQFSLVKPLIPSVDFLF 366 green anole
XP_022538809 444 SPKPNNSYMFKREPPEGCEKIKVF-EE-MTSRQSAAvPLFSCPDKNKVNFIP-TGSAFCPVKLPGSLLQHSASQP 515 Mexican tetra
XP_014346814 404 SPKPNHSYLFKREPPEGCERVKVFeEA-LSPSHGDA-VLTSCPDKNKVHFIP-TGSAFCPVTIFKPLLPTMDLIL 475 coelacanth
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