5YBW,6L0P,1Z7Y,3DWG


Conserved Protein Domain Family
PALP

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pfam00291: PALP 
Pyridoxal-phosphate dependent enzyme
Members of this family are all pyridoxal-phosphate dependent enzymes. This family includes: serine dehydratase EC:4.2.1.13 P20132, threonine dehydratase EC:4.2.1.16, tryptophan synthase beta chain EC:4.2.1.20, threonine synthase EC:4.2.99.2, cysteine synthase EC:4.2.99.8 P11096, cystathionine beta-synthase EC:4.2.1.22, 1-aminocyclopropane-1-carboxylate deaminase EC:4.1.99.4.
Statistics
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PSSM-Id: 459749
Aligned: 145 rows
Threshold Bit Score: 78.5066
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5YBW_B         18 ISKHILYTPV-----FTSPTFD----RMVGSKagrqFYFKAENLQ-KTGSFXARGAL---NAILCaLEREp-----SLAG 79  Anadara brough...
WP_012530390   72 KYRLWRPAPL-----FRARRLE----QALQTPa--kIYYKYEGVS-PAGSHKPNSAI---PQAYY-NKQAg-----IRRL 130 Citrifermentan...
Q9HKD2         69 YMQVGRPTPI-----IRAKKLE----ELLGGNl--kIFLKMESYT-YSGSHKINSAL---AHVFFaREEG------AKFV 127 Thermoplasma a...
Q8KXV4         42 KNYAGRPTAL-----TKCQNIT----AGTNTT----LYLKREDLL-HGGAHKTNQVLg--QALLA-KRMG------KTEI 98  Shigella boydii
Q5B1Y6        113 ASPFLRPSPL-----HLAHSLT----KAVGGAn---IWLKRDDLN-PFGSYQTRNIV---GQILFaQHIG------KTEI 170 Aspergillus ni...
Q8Q0K3         60 lTTEAGPITYksealAKELGLSnlyiGFSG------YWPEREALI-KTCSFKELEAH---PTMQL-LKES------GGKA 122 Methanosarcina...
Q5ZUZ9         98 LTFSF---PL-----HHLFKKS----------------YVLELFHgPTLSFKDLGTQffsECLLH-LIEN------KSAK 146 Legionella pne...
Q9ZMX5         74 KRYENFDNPK-----NPAPIFA------LNER----LFVQELYHG-PSLAFKDMALQplaSLFSN-LAVGk----nEKYL 132 Helicobacter p...
jgi:Pput_0696  82 GFRHRGIAPL----------------QQLGHN----EWILQLFHG-PTRSSKDFAAQ----LQAR-FVRHflgaecERVM 135
jgi:Swoo_2012  84 LIMCGRPTPL-----RRALSLE----KHLKTPa--rIYFKREDTM-ATGSFKLSTAV---AQAYY-AKQE------GREI 141
5YBW_B         80 VVTHSS-GNHGQALAWASK--RA-GV-KCCVV--VPKTAP---Q-VKFDAMENYGA---EVVKC-------EPN-----P 133 Anadara brough...
WP_012530390  131 ATETGA-GQWGSSLALACS--MF-GL-ECTIY--MVKVSCtqkP-YRKSMMQLWGA---TVIPSpseftnaGRSilahdP 199 Citrifermentan...
Q9HKD2        128 STETGA-GQWGSAVALASA--LF-HM-ESHIF--MVRTSFyakP-YRKYMMYMYGA---HPHPSpsefteyGREvlkrmP 196 Thermoplasma a...
Q8KXV4         99 IAETGA-GQHGVASALASA--LL-GL-KCRIY--MGAKDVerqS-PNVFRMRLMGA---EVIPV-------HSG-----S 155 Shigella boydii
Q5B1Y6        171 SMECGF-AGHGLFCATMCA--RM-NM-KCTIL--MGASDIaa-qpDAVEEMKQLGA---TVVSVqcsisddGSGtlraaT 239 Aspergillus ni...
Q8Q0K3        123 IVLASA-GNTGRAFAYSSS--LT-GT-DAYIV--VPDSGV-----SSIWLPEEPAN---SIHLIsm---tpGND-----Y 179 Methanosarcina...
Q5ZUZ9        147 VLVATS-GDTGAAIAHALD--GKrDL-EGIIL--FPKDKL---TfRQQSQITCWGE---NIRALa-----vNGS-----F 204 Legionella pne...
Q9ZMX5        133 VLVSTS-GDTGPATLEGLA-----GMpNVFVVclYPKDGT-----SLVQKLQMVTQnasNLKVFg-----vSGD-----F 191 Helicobacter p...
jgi:Pput_0696 136 LVGASN-GDTAVAAIEALRhcPAaG--LLALY--PSAGTP---A-DRAAVMRSAASdsvSCVAV-------DGS-----F 194
jgi:Swoo_2012 142 LISETGaGQWGMSVALVSQ--MF-GL-DARIF--MARCSLeqkP-YRQHYMKMLGC---EVYPSpstktecGKElllqtP 211
5YBW_B        134 TSRKETc---eGLAKSr---------GYKYISSSd-------DYD-----VIAG-QGTIALEL--------LQQQ----P 176 Anadara brough...
WP_012530390  200 NNLGSLg---iAISEAvedaathddtNYALGSVLn---------------HVCLhQTVIGLEAke----qmELAG----D 253 Citrifermentan...
Q9HKD2        197 DTPGSL-----GLAISeaihyaldngGKYIAGSVi-------NSD-----ILF--KTIAGMEAkk----qmEMAG----E 249 Thermoplasma a...
Q8KXV4        156 ATLKDAc---nEALRDw--------sGSYETAHYmlgtavgpHPYp---tIVREfQRMIGEETkaq---isEREG----R 214 Shigella boydii
Q5B1Y6        240 NEALRY-----SLTRLn---------STYHISTGtvg--phpLPT-----ITRTfQSLLGQEIki----csSELPgrgrR 294 Aspergillus ni...
Q8Q0K3        180 TDAINLa---gRLAKLp---------GMVPEGGAr-------NVA-----RREG-MGTVMLDAa-------VTIG----K 223 Methanosarcina...
Q5ZUZ9        205 DQCQQLvklvfAKREHk---------GILTTANSm-------NIArllpqIIFYaFTSIQLAL---------RHN----H 255 Legionella pne...
Q9ZMX5        192 DDAQNAl---kNLLKDdd------fnEALKARQLk-------LSV-----ANSVnFGRIAFQIvyhiwgflELYKkgaiN 250 Helicobacter p...
jgi:Pput_0696 195 DDCQSLv---sALLRDw--------pCPGLIPVSf-------NST-----NWVGvLAQIVFYF----------------- 234
jgi:Swoo_2012 212 GHPGSIgsaisEAIENald-----tpGSAYLSGS--------NVN-----HVHLhQTLLGLEVkq----qlSMAGe---S 266
5YBW_B        177 DLDA----ILVSVSAG-GMASGICVYTKN----TKSD--------LKVF-LVEPEgkMLEECISKRerlwpnppqfl--- 235 Anadara brough...
WP_012530390  254 YPDI----VIACCGGG-SNFAGLAFPFLS----DRANgk-----kVRCL-AVEPA--SCPTLTKGIyafdygdtaklapi 316 Citrifermentan...
Q9HKD2        250 DPDY----IVGVVGGG-SNYAALAFPFLAdelsSGKI--------RRTYiASGSK--EVPKMTEGEyrydypdtgkvlpl 314 Thermoplasma a...
Q8KXV4        215 LPDA----VIACVGGG-SNAIGMFADFI-----NETN--------VGLI-GVEPGghGIETGEHGAplkhgrvgiyfgmk 275 Shigella boydii
Q5B1Y6        295 KNNFrpsaLVSTSGAA---ALGMFAPFI-----SDPA--------VRLI-AVEAA--DAAPLTHGSpgvmygcktlllqd 355 Aspergillus ni...
Q8Q0K3        224 MPDH----YFQAVGSGtGGMSAWEASLRLrddgRFGSk------lPKLQ-LAQNL--PFVPMYNAWkagrreiipdidmk 290 Methanosarcina...
Q5ZUZ9        256 SVN-----FIVPGGNL-GNVTACYWAKML----GFPV--------EQIL-IANNI---NSALGEFLltgayqaksvtk-- 311 Legionella pne...
Q9ZMX5        251 SKEK----ITLAIPSG-NFGNALGAFYAK----KMGL---------NIA-KIKVVtnSNDVLREFIetgrydlt------ 305 Helicobacter p...
jgi:Pput_0696 235 ---H----AALQLGGG-IRPVGFSIPTASfaeiYAGFiaqkmglpINQI-IVSTN--RNDALHRFIhcnrysrgstsq-- 301
jgi:Swoo_2012 267 NVDH----LVACVSGG-SNLCGFMMPFLPek-nSGAK--------IDML-GVEST--ASPRLTQGTyeycrsdvagytpe 329
5YBW_B        236 -------------dtiadgiilqQCGNKTWPII---LELPEk----EVITVNNDNIVEAMRFVFARMKLVIEA-AAGATV 294 Anadara brough...
WP_012530390  317 tkmytlghdfmppgihagglryhGESALISQLY---HAGEI-----EAKSYKQNACFEGALLFARSEGIVPAPeSSHAVR 388 Citrifermentan...
Q9HKD2        315 lkmy-tigydfippavyagglryHAVAPTLSLL---MNKGIv----SARDYDQEEAFKWARIFSETEGYIPAP-ETSHAL 385 Thermoplasma a...
Q8KXV4        276 a-------pmmqtedgqieesysISAGLDFPSVgpqHAYLNstgraDYVSITDDEALEAFKTLCLHEGIIPAL-ESSHAL 347 Shigella boydii
Q5B1Y6        356 eng---qilpshsispdlnfpcaGPELAHWRDL---GRLET-------VTASSEEAVRGLRILCESEGIVPGLaTSHAVL 422 Aspergillus ni...
Q8Q0K3        291 da-----kkqieetyatvltnraPPYSITGGLYdalVDTDG-----IMYAITREEALEAKALFESLEGIDILE-PSAVAA 359 Methanosarcina...
Q5ZUZ9        312 ------------tlatamdvgepSNLDRLFVLF---NNYSEckkqmNAESVSDEQIKQAILHCYNKYHYIICP-HTATAY 375 Legionella pne...
Q9ZMX5        306 ---------------krslkqtfSPAMDILKSS---NVERA-----LFSLFGFERTLELMQALEEEKFYALKP----KEL 358 Helicobacter p...
jgi:Pput_0696 302 -----------tlspvmdfslfsNLERFVWELY---DRDGG-------ATRALMEHFEACGELSIGNRQWL---HARMLF 357
jgi:Swoo_2012 330 vlshsmgesyipapvhvgglrnhNSSPLVSLLC---REGIL-----RAEALDEFNAFKAGQIMLKTEGILVAP-ESSHAV 400
5YBW_B        295 AAAmtERFQNFHPEAk-KVGIILCG 318 Anadara broughtonii
WP_012530390  389 AAIdeAVLAKEEGKEk-TILFGLSG 412 Citrifermentans bemidjiense
Q9HKD2        386 PILkeIADKNRGEKK--TVLVSFSG 408 Thermoplasma acidophilum DSM 1728
Q8KXV4        348 AHA--LKMMRETPEKeqLLVVNLSG 370 Shigella boydii
Q5B1Y6        423 ETV---RVARQLGIGk-DVVLLISG 443 Aspergillus nidulans
Q8Q0K3        360 ASLlkAVEAGNVEKDd-VILLNIAG 383 Methanosarcina mazei Go1
Q5ZUZ9        376 HRL------STINQDk-PWVIVAPG 393 Legionella pneumophila subsp. pneumophila str. Philadelphia 1
Q9ZMX5        359 ALLqeHFSCASCSDE--DCLKTIQE 381 Helicobacter pylori J99
jgi:Pput_0696 358 DSY--AVDDALIREE------IVTl 374
jgi:Swoo_2012 401 AAAidLAEKARIENKesVIVFLASG 425
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