7P14


Conserved Protein Domain Family
XK-related

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pfam09815: XK-related 
XK-related protein
Members of this family comprise various XK-related proteins, that are involved in sodium-dependent transport of neutral amino acids or oligopeptides. These proteins are responsible for the Kx blood group system - defects results in McLeod syndrome [MIM:314850], an X-linked multi-system disorder characterized by late onset abnormalities in the neuromuscular and hematopoietic systems.
Statistics
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PSSM-Id: 462912
Aligned: 117 rows
Threshold Bit Score: 145.065
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
7P14_A         10 MSVLGIIIYVTDLVADIVLTVRYFYDGQYVFGVLTLSFVLCGTLIVHcFSYSWLKDDLKKAGgenehYFLLLHCLQGGVF 89  
AAU94452       40 SVVLATALYCAEFVSAAVLSGKYHSTKDDTWLGFTITFMLVPAVLIQ-LALTFIHRDAGRDRp----LVLLLHLLLLGPV 114 
Q5U3R0         43 SVLWATVLYCAEFICASVLSSMYHKTEDVVWMGLTITFMLVPSVLTQ-LTLTFVHRDLGRDRp----LVLFMHLLQMGPI 117  zebrafish
XP_006633092   43 SVVLATALYCAEFITAAVLCSIYDRSGDRFWMAFTITFMLVPAVLVQ-LALTFIHRDLGRDRp----LVLFMHILQMGPV 117 
XP_005992052   36 SILISTILFCGELIAAGVLCGCYNQSKDQVWLALTLTFMLVSSVLIQ-FALIFIHRDLTRDRp----LVLFLHLLQLGPL 110 
Q5GH21         32 SIFTSTILFCAEIVAASVVAAGYSYSEDESWMSLTIVFMLVPSIMVQ-LTLTFIHRDLGRDRp----LILLMHLLQLGPI 106  tropical claw...
XP_002719876    6 SVLASVFLFVAETTAALYLSSTYRSAGDRMWQALTLLFSLLPCALVQ-LTLLFVHRDLSRDRp----LVLLLHLLQLGPL 80  
XP_003218964    6 SVLVSLFLFVAETACALYLSSTYCSAGDRIWQSLTLLFALLPCVLVQ-FSLVFVHRDLSRDRp----LVLLLHILQLGPI 80  
XP_004940756   22 GIVFSTALFCGESAAAAVLCFSYSHSDDRFWLALTIFFVLCPSVLVQ-LTLIFVHRDLSRDRp----LVLLMHLLQLGPI 96  
KAA8588755     44 SVVLATVLYCAEFVSAAVLCSMYHKTDDDIWMGLTITFMLLPAVLIQ-LALTFIHRDLGRDRp----LVLFLHLLMLGPV 118  orangethroat ...
7P14_A         90 TRYWFVLRTGYHVVfkhShrtsN------------------------FMEEQTDPhkEAIDMATDLSMLRLFETYLEGCP 145 
AAU94452      115 IRCFEALIVYFK-----A----Gkkeetyvtlsr--kislkkgqkipTEWEIGQSerTLAAHRNAFKRTAVIQAFLGSVP 183 
Q5U3R0        118 IRCIEAIVVYCQ-----A----GkneepyvtisrkiklkhgrglgpaFECEIGHSerKLAVHRNAFKRTAVIQAFLGSTP 188  zebrafish
XP_006633092  118 IRCVEALIVYFR-----S----Gkgeepyvtisr--kirlkhgqgtpTEWEIGHSerTLATHRNAFKRTAVIQAFLGSAP 186 
XP_005992052  111 VRCMESLVVYYR-----A----Grkeepyvsitr--kkqlkkgcereVEQEVGHSlrKLATHRNAFKRTAVIQAFLGSTP 179 
Q5GH21        107 IRCVEALTVYCT-----M----Greeepyvsisrk-kklqgwgeaeeEEREVGHSlrRLATHRNAFKRTAVVQAFLGSTP 176  tropical claw...
XP_002719876   81 FRCFEAFCIYCQ-----S----Shneepyvsitkk-rqipknglseeIEKEVGQAegKLFTHRSAFSRASVIQAFLGSAP 150 
XP_003218964   81 VRCVEVFCIYFQ-----A----Grveepyvsitkk-rqmpkdghsdeIEKEVGQAegKLFTHRSAFSRASVIQAFLGSAP 150 
XP_004940756   97 IRCVEALVVYCWSGqeeE----Pyvtitrkrr-------lrkgyeveLEQEVGHSvrRLATHRNAFKRMAVIQAFLGSTP 165 
KAA8588755    119 IRCFEALVVFFK-----A----Gkkeepyvtisr--kislkkgqgmpMEWEIGQSerNLATHRNAFKRTAVIQAFLGSAP 187  orangethroat ...
7P14_A        146 QLILQLYAFLERGqANFs--QYMVIMVSCCAISWSTVDYQIA-LRKSLP-DKNLLrGFWPKLTYLFYKLFTLLSWMLSVV 221 
AAU94452      184 QLTLQMYATIQE--KYApsaRLALMIINLVSITYGALVCNVLaIHIRYDdYKVRV-RPAAYLCMTVWRGLEIATRITVLV 260 
Q5U3R0        189 QLTLQLYATIQEK-YILlpsRLALMIISLISITYGALVCSVLaIQIKYDdYKVRM-KPTAYLCMILWRGLEIATRITTLV 266  zebrafish
XP_006633092  187 QLTLQLYATIQEK-GLTattRVVLMAIALLSITYGALVCSTLaIQINYDdYKYRL-RLPAYACMVLWRGLEIATRVTVLV 264 
XP_005992052  180 QLTLQLYVSVME--ETIlpeRVALMVISLLSVTYGALVCNVLaIQIKYDdYKIQL-KFTSYLCIILWRSLEIATRVTVLI 256 
Q5GH21        177 QLTLQLYVSVLE--RNVppaRAVLMAMCLASTTYGALILNVLaIQIKYDdYKVRL-SVPAFLCIVMWRCLEIATRVTVLV 253  tropical claw...
XP_002719876  151 QLTLQLYISVLQ--QHVtvgRCFLMTLSLLSIVYGALRCNILaIKIKYDeYEVKV-KPLAYVCIFLWRSFEIATRVTVLV 227 
XP_003218964  151 QLTLQLYICVLQ--QEItaaRSIFMTLSLLSIVYGALRCNILaIKIKYDdYDVNI-KPMAYLCIFLWRSFEIATRVIVLV 227 
XP_004940756  166 QLTLQLYISILE--KYVpvtRAILMGICLVSVTYGALVCNVLaIQVKYDdYKVQL-RPLAFLCIVLWRSLEISTRVAVLV 242 
KAA8588755    188 QLTLQLYATIQE--KYIlpaRLALMVITLISITYGALVCSILaIQIRYDdYKVRL-RPLAYVCMIVWRVLEIATRITALV 264  orangethroat ...
7P14_A        222 LLLFVDVRTVLLLLLFLWTVGFI--WAFINhTQF------------CNSLSMEFLYRLVVGFILVFTFF----------N 277 
AAU94452      261 LFSTALKYWVVLVGSLNLLFFFFqpWTEFWaKKGsltqglernfshFGTVVVLSLFTLLYACINVFCWSavqld-fthrE 339 
Q5U3R0        267 LFSTAFTVWVVLVGLINLFIFFFqpWVEFWaRRAslpenvennfskLGTTVVLCMVTFLYACINIFCWSavqln-ladhD 345  zebrafish
XP_006633092  265 LFSTALPVWVVPVGLANLLFLFFlpWVEFWaKRAalpenveknfskVGTTVVLCLVTFLYACINMFCWSavqld-ladrD 343 
XP_005992052  257 LFCTALKIWILPVVLVNMLTLFFlpWVRFWrSKAsfpenieknfskVGTTVVLSMVIFLYASINMFCYSavqln-lsdrD 335 
Q5GH21        254 LFCSALKAWVAAVALANLLALFLlpWVKFWsSGDslpqnieknfswFGTVTVLGSVTLLYSAINMFCWSavqln-lsdrD 332  tropical claw...
XP_002719876  228 LFTSVLKTWVVAVILLNFFSFFLypWILFWcSGSpfpeniekalsrVGTTIVLCFLTLLYTGINMFCWSavqlk-idnpE 306 
XP_003218964  228 LFSSVLQIWTLPVVLVNFFAFFFhpWILFWqSKCtlpeniekalskVGTTIVLCLLTFLYAGINMFCWSavhlk-lndaD 306 
XP_004940756  243 LFSTVFKHWIIPIALANLLVVFFqpWVQFWrSGTrlpdnieknfsrVGTVVVLFAFTLLYASINMFCWSavqlkladrdL 322 
KAA8588755    265 LFSTALTHWVILVGMSNLLFFFFlpWVEFWaRKSsltqdveknfskLGTTVVLCMFTLLYACINIFCWSavqld-lshrE 343  orangethroat ...
7P14_A        278 -IKGQNTKCPMSCYYTVRVLGTLGILTVF-WIYPLSifnSDYFIPISATIVLSLLFGIIFLGvyYGTYHP 345 
AAU94452      340 lIQRRQGWGRLALYYCARFVENFVLITLWyFNKSDFf-eYVCAPLLVVQLLIGYSMSVLFMLvfYQFCHP 408 
Q5U3R0        346 lVEKQPRWRSLAVYYTLRFVENVTLIVLWyYFKSDFy-eYVCTPLLVVQLIVCYTLAVLFMLlfHQFCHP 414  zebrafish
XP_006633092  344 lIDKSQSWGRLAVYYVVRFAENTILIVLWyFFKTDFy-eYICAPLLVVQLVVCYSLAILFMLvfYQYCHP 412 
XP_005992052  336 lIDKAQNWGRLALYYTVRLLENTGLILLWyFFQTDVh-eNICTPLLVLQLLAAYCLAIFFMLifYQYCHP 404 
Q5GH21        333 lIDQSQNWGRLSLHYTIRLLENAALILLWyFYKEDVf-eYFCSPLLVVQLLVGYATAIFFMLlfYQYLHP 401  tropical clawed frog
XP_002719876  307 lISKSQNWYRLLVYYMMRFIENATLLLLWyFFKTDIy-mYVCAPLLVLQLLVGYCTAILFMLvfYQFFHP 375 
XP_003218964  307 lIDKSQNWCRLALYYLLRFLENAFLLLMWyMYKTDVy-tYVCAPMLFLQLLIGYCIAVLFMLafYQFCHP 375 
XP_004940756  323 -IDKSQNWGRLAVYYVARLLENTALVVLWyFFKTDVy-eNICTLLLVVQLLLGYCLAIYFMLlfFQYLHP 390 
KAA8588755    344 lIERKQRWGRLAMYYGARFVENFLLITLWyFFKSDFy-eYVCAPLLAVQLLICYSLAVLFMLlfYQFCHP 412  orangethroat darter
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