1HZM


Conserved Protein Domain Family
DSP_MapKP
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cd01446: DSP_MapKP 
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N-terminal regulatory rhodanese domain of dual specificity phosphatases (DSP), such as Mapk Phosphatase. This domain is believed to determine substrate specificity by binding the substrate, such as ERK2, and activating the C-terminal catalytic domain by inducing a conformational change. This domain has homology to the Rhodanese Homology Domain.
Links
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Statistics
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PSSM-Id: 238723
Aligned: 27 rows
Threshold Bit Score: 81.9446
Created: 23-Jun-2004
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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putative
Conserved site includes 3 residues -Click on image for an interactive view with Cn3D
Feature 1:putative substrate binding residues
Evidence:
  • Comment:These residues have been shown to be critical for ERK2 binding in MapK Phosphatase by mutagenesis experiments
  • Comment:believed to be involved in substrate specificity regulation
  • Structure:1HZM_A showing solvent-exposed conserved residues
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                           ###                        
1HZM_A      17 SKTVAWLNEQLelg------nerLLLMDCRPQeLYESSHIESAINVAIPg-IMLRRLQkgnlpvralftrgeDRDRFTrr 89   human
P32586       4 LLSKDEFNSTLksfee--qtesvSWIIDLRLHsKYAVSHIKNAINVSLPt-ALLRRPSfdigkv---facikCNVKVSld 77   fission yeast
T49403     349 MIDPARLKDLMdqgd-----dsdLLLLDIRVSpQYAVSRVKGALNLCIPt-TLLKRATfnlqklqqtfsanqDQDRFSnw 422  Neurospora crassa
P40048      97 LITAVELGKIIetlp-----dekVLLLDVRPFtEHAKSIITNSIHVCLPstLLRRKNFtfskll--dnltpsEQSVLKsk 169  baker's yeast
Q9Y6W6     149 IIYPNDLAKKMtkcskshlpsqgPVIIDCRPFmEYNKSHIQGAVHINCAdkISRRRLQqgkitvldliscreGKDSFKri 228  human
CAG09195   151 VIHPNELAKRLiccplghpvgpvPVIIDCRPFmEYNKSHIRGAVHINCSdkISRRRLQqgkitvldlischeGKDSYKgi 230  Tetraodon nigrov...
O09112      10 VMDAKKLASLLrgg------pggPLVIDSRSFvEYNSCHVLSSVNICCSk-LVKRRLQqgkvtia-eliqpaTRSQVDat 81   house mouse
NP_957174   10 AMDIKRLAGLLqrg------agrLLVIDSRTFsEYNASHVHGAINVCCSk-LVKRRLQqdkvsvt-ellqpnGKVKVDlg 81   zebrafish
Q9BY84       9 QIVTERLVALLesg------tekVLLIDSRPFvEYNTSHILEAININCSk-LMKRRLQqdkvlit-eliqhsAKHKVDid 80   human
NP_998405   10 PIGPQALVALLegr------verVLLIDCRPFvEFNSCHILEAVNINCSk-LMKRRLQqdkiqis-ellqhcAKRKLElq 81   zebrafish

Feature 1                                                                     
1HZM_A      90 c--gtDTVVLYDEsssd---wneNTGGESLLGLLlkklkdegCRAFYLEGGFSKFQAEFSLHC 147  human
P32586      78 ---eiNAIFLYDSsm------agMNRIYDLVQKFrrg--gysKKIYLLSNGFEAFASSHPDAI 129  fission yeast
T49403     423 r--naKYLVVYDAsssd---krdAMGAINMIKKFtne--gfsGSANILRGGFRAFAETYPNLI 478  Neurospora crassa
P40048     170 laidnLRIIIYDStanqt-essvSLPCYGIASKLiefdtnvkKTVSILMCGFPQFKILFPDHI 231  baker's yeast
Q9Y6W6     229 ---fsKEIIVYDEntnepsrvmpSQPLHIVLESLkr----egKEPLVLKGGLSSFKQNHENLC 284  human
CAG09195   231 ---fsKEIVVYDEstadpnrltfSQPLYVVLESLrr----egKDPIVLKGGLSCFRQSHENLC 286  Tetraodon nigroviridis
O09112      82 ---epQDVVVYDQstrdasvlaaDSFLSILLSKLdg----cfDSVAILTGGFATFSSCFPGLC 137  house mouse
NP_957174   82 ---rrQEVVVYDQstkdtgqlskDSFVHILLSKLds----tfHRVSLLTGGFAAFSSCFPGLC 137  zebrafish
Q9BY84      81 ---csQKVVVYDQssqdvaslssDCFLTVLLGKLek----sfNSVHLLAGGFAEFSRCFPGLC 136  human
NP_998405   82 ----gQEVVVYDQssgdpaslspDAFLSVLLVKLek----sfPSVHLLSGGFLQFSGLFPGLC 136  zebrafish

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