Conserved Protein Domain Family
PPIP5K2_N

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pfam18086: PPIP5K2_N 
Diphosphoinositol pentakisphosphate kinase 2 N-terminal domain
This is the N-terminal domain found in the Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 (PPIP5K2), EC:2.7.4.24. Structure analysis of human PPIP5K2 indicate that this region forms alpha-beta-alpha domain.PPIP5K2 is one of the mammalian PPIP5K isoforms responsible for synthesis of diphosphoinositol polyphosphates (inositol pyrophosphates; PP-InsPs), regulatory molecules that function at the interface of cell signaling and organizmic homeostasis.
Statistics
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PSSM-Id: 465643
Aligned: 46 rows
Threshold Bit Score: 138.808
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
CUA76923       46 VVVGVCAMDVKARSKPMREIITR-LVERgrGCIEVKLFGEQVILGEDVENWPRCDILISFFSTDFPLFKAVEYVKLRNPV 124 
EOD18125       69 ITVGVCVMRKK--CEKLRPLLAE-MTSG--GDMTVVVFEQQSILEDAVSDWPVVDVLVAFYSKGFPLAKVGEYVRLREPF 143 
EFJ50447      517 IRLGVCAMARKAKSRPMREILSR-LTTC--NEFELVVFEEEVILQQPVDRWPVVDCLLSWYSEAFPLRKAQEYVERVRPF 593 
XP_001033115   50 IRIGICAMNKKVTSKPMQKILEL-LKT---NDFEMVIFDEETIQKKPIQDWPIVDCLISWFSEGFPLQKAQSYAKLRNPF 125 
EKC28515       30 IVLGVCAMQKKSNSKPMHEILGR-LEKF--MQMQTMIFDEDVILNKPIEEWPIVDVLISFFSAGFPLDKAIEYTKLRQPF 106 
A0CR44         37 VTIGVCCMAKKSQSKEMQEILNR-INP---EFFKIEIFSEQMILEDPIESWPIVETLISFYSDGFPLNKAIAYVDLRKPF 112  Paramecium te...
ESO89767        4 IIVGICAMAKKSRSKPMKEILQRlLQHF--ERLEILIFDEDVILSEPVEKWPIVDALISFFSHGFPLDKAIQYSNLRKPY 81  
VDK20933       15 IILGVCAMAKKTKSKPMKEILRR-LEKF--QHIKVIVFEEKVILKHPIEAWPLCDALISFYSDGFPLQKAIAYAELRRPY 91  
VDN10842       13 VTLGVCAMAKKTKSKPMKEILRR-LEKF--QHIRILVFEESMILNTPISSWPVCDALISFYSEGFPLEKAIAYAQLRSPY 89  
Q54PE2          4 ISLGICCMEEKLKCNVMKYFIKK-LKEF--KELEIIEFDSNTIFNLPIQEWPIVDSFLSFYSNGFPLEKAIRYWKLRRPY 80   Dictyostelium...
CUA76923      125 CVNDLHAQALLWD 137 
EOD18125      144 CFNAIGPMSELLD 156 
EFJ50447      594 CVNDLAAQEVLLD 606 
XP_001033115  126 LINDLEKQNLLFD 138 
EKC28515      107 VINDLESQYTLLD 119 
A0CR44        113 IINDLKKQQLLWD 125  Paramecium tetraurelia
ESO89767       82 VINDLEMQHVLKD 94  
VDK20933       92 LVNDLKAQYVLMD 104 
VDN10842       90 LINDLDAQYVLMD 102 
Q54PE2         81 LVNDLELQLLLQD 93   Dictyostelium discoideum AX4
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