4OU9,5J55


Conserved Protein Domain Family
RPE65

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pfam03055: RPE65 
Retinal pigment epithelial membrane protein
This family represents a retinal pigment epithelial membrane receptor which is abundantly expressed in retinal pigment epithelium, and binds plasma retinal binding protein. The family also includes the sequence related neoxanthin cleavage enzyme in plants and lignostilbene-alpha,beta-dioxygenase in bacteria.
Statistics
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PSSM-Id: 460788
Aligned: 494 rows
Threshold Bit Score: 258.686
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4OU9_A    24 YQSQPQEW-DYw-----vE--Dv--E-GSIPPDLQGTLYRNGPG-LLEIg--------------DRPLK-HPFDGDGMVT 76  Synechocystis sp. P...
CCE29580  42 AFDGLDNQrESv------Q--Lg-vN-GHIPSWAAGTFYRTGPGqSVIEnts----------rgTHHVS-HWFDGFAQVH 100
EGX90311 145 GFEGLEEHrGPi------E--Lk-vR-GSIPAWTAGSLYRTGPGqSSVEtds----------kgTYNIS-HWFDGLAHSH 203
EXX76768  48 GFSNAGETlTP----------VelkVsGELPSWLSGELYTVGPGtYDIKytrmieseggfesatETFSMgHWFDGLPLVN 117
EPB84051 170 GFQNFHDSdKI----------DdlnVtGQLPEWLVGEHFTIGPStFDIKytrkieidgelqnasAFYTFgHWFDALPLVN 239
EPB85659  76 GFYNAKDSkDV----------VdlvVdGQLPEWLTGEYYTIGPGtYDVRysrkievdgmlqsatATFTLgHWFDALPLVN 145
EIE87137  69 GFCNTTDSkQV----------VdleVdGQLPDWLASEHYTIGPGtYDVKytrkieidgilqsatATFTLgHWFDA----- 133
EPB86031  20 GFKNVPSVeSP----------VtlkLdGQIPSWVNGVMYRSGSGrYNVLldn----------gdTFHIG-HPFDGLAMLH 78 
EIE76803  30 IQSMQKPVmLGntpecqdRitLekvS-GQLPSWLNGVMYRVGPGvFNIKqkn----------giTYTIR-HAFDGLPMVH 97 
EPB91835  40 KLSNTPEVqDPv---------VlqlQsGQIPSWLNGIMYRIGPGrFNIQqnd----------gsTFSIR-HAFDGLPFMH 99 
4OU9_A    77 AFKFPg--------Dg-rVHFQSKFvRTQGYVEEQKAGK----------------------------------------M 107 Synechocystis sp. P...
CCE29580 101 KFDLIpslldetncS---VTYTSRF-QSEEYIKFVRRKGwradlsfgqrs------------------dpcvglfakfmS 158
EGX90311 204 KFDITppskpggrtS---VVYSSRR-QSKRLEQHIKETGkrttpsfgqra------------------dpcmgifskvmG 261
EXX76768 118 RFEFDg--------KdgkIKYRSRItSRKYEIKIRDHHGivtrhp----------------------------------- 154
EPB84051 240 RFDLNg--------SrnsVTYRHRStSRRLVEKIREHHGyapqhp----------------------------------- 276
EPB85659 146 RFDLNg--------ErntITYRNHLvNKKLGEKIRDHHGyapnyp----------------------------------- 182
EIE87137 134 -----------------------------------DHHGyapnfp----------------------------------- 143
EPB86031  79 RFEISg--------EtqsVKYNSRHtSHGVE---RRIGQrdptlltfgpdpcktifgriqsvyhhiskfganaalqendA 147
EIE76803  98 RFQLNg--------StqtVTYNSRHtAKSLE---KEISS----------------------------------------- 125
EPB91835 100 RFEVNg--------StqtLKYNSRMlAKSLE---TEIKN----------------------------------------- 127
4OU9_A   108 IY---Rgvfgsqpagg-----------------------wlktifdlrlKNIANTNIT---------------------- 139 Synechocystis sp. P...
CCE29580 159 LFtp--------------------------------------------rQINNNVTVLpnipgmmqd------------t 182
EGX90311 262 VFaprD-------------------------------------------QYNNNVVLLpnfpgidkdr-----------k 287
EXX76768 155 ---------------------------------------------ftlfkTHANQTPLaklfgqkrtdkpemepcsvnis 189
EPB84051 277 ---------------------------------------------nalymSNTNQTVLskflgsskaskpd----aepca 307
EPB85659 183 ---------------------------------------------aglfkTNANQTMLikflnngkalkpd----ripcg 213
EIE87137 144 ---------------------------------------------aglfkTHPNQTMLikflnngkkpkpd----rvpcn 174
EPB86031 148 EF------------------------------------------------DMVNVTVTpnfplga--------------- 164
EIE76803 126 -----GadkglvffghvpevsfltwlinwivrlnnlvlrpkpihltkpdGRSVGVTVTpnytlpa--------------- 185
EPB91835 128 -----KsfkgliffghipemtfpqwlynfyvrfnnlilspkprhdgrpdGQSVGVTVTpnfplp---------------- 186
4OU9_A   140 --------YwGDRLLALW-EGGQPHRLEPSnLATIGLDDLggilaegQ-PL---------SAHPRIDpastfdGGQPCYV 200 Synechocystis sp. P...
CCE29580 183 dtshkdfqNePSNLYVCT-DNATLQKLDPItLEPLGKATQ-------R-SLhpdlkgpmsCAHAQRD------PETGDLF 247
EGX90311 288 pteqtgprLgLDNLYIST-DTAGLQKIDPQtLEPLGYTDQ-------S-SLhpdlkgplsCAHAQRD------PENGDLY 352
EXX76768 190 tkfpfyksGeKPKVFCQN-HASQVVELDAHdLAPSRVYSWn------DiNPlfrg--dhaSPHPHYD------DNTGELI 254
EPB84051 308 arilanipGlEGRLFAQN-YANHVQELDPFdLKPTRLLQWn------EiNPkfkg--tssCPNGKYD------SRTGEYI 372
EPB85659 214 qrittrlpGiDGRLFCQD-FANHIQELDPFdLTPTRVETWn------ElNPelkg--yssCPNGQFD------TETGEYI 278
EIE87137 175 qrimtqvpGlDGRLFTQN-FANHIQELDPFdLTPTQVQTWd------EiNAdfkg--yssSPNGQVD------PETGEYI 239
EPB86031 165 -dleqetgVkRGEALVVKrDANTLQVVDPEtLKPLKMFtyahvsk--------klqgqlcASHHQYD------EETDEYI 229
EIE76803 186 -rvsmnndLsKKSLVAKT-DANVLQKLHAEtLVPeiifsykny--------dphlngpfsAAHHQFD------PETNEIF 249
EPB91835 187 --arikkaDgENVLVSKT-DANVLQKIHAEtLEPqnifnytsy--------darikgqlsAAHHQYD------PNTKEIF 249
4OU9_A   201 TFSiksslsstltlleLD-P--QGK-------------------------LlrqktetfpgFAFIHDFAITPHYAIFLQN 252 Synechocystis sp. P...
CCE29580 248 NFNlepgrt--atyriFRvNaaSETvdil------------------atiAdke-----laAAYIHSFFLTDNHVILCVP 302
EGX90311 353 NYNlefgrf--gtyrlFRvNasTGKtevf------------------atvSepg-----iaPAYIHSFFLTPNYMVLCIP 407
EXX76768 255 NFNmevyal-gtkynfFSiTekNPNgefi------------------asiSa--------kASYVHSFAVTQRFIILVVF 307
EPB84051 373 NFSmevgyq-svkynfFSiSdkNPKgsl-------------------lasVta-------pMAYVNNFSITPKYIIFVIC 425
EPB85659 279 NFTmeigyr-stkyhfFSiSeqHPKgepi------------------atiWna-------pTGWVNNFALTPNYIVMVIH 332
EIE87137 240 NFTmeigyr-ttryhfFSiSnqEPKghpi------------------ttiWna-------pTGWVNGFALTPNYIVMVIH 293
EPB86031 230 NFMvklgpf--ptfqtFSlGpyLPSppgekeampapeprlhqpiwrhlgaWktme---alkPSYIHSFSMTKNYIIIPNF 304
EIE76803 250 NFSlhlfpk--skmtvFKtSkeGQTtllae----------------ithrKgdhs---efrASYIHSFYLTKNYVIIPES 308
EPB91835 250 NFAlttgpv--prlvvFStTeaGKVtila-----------------dfthRtdks---piqAPYIHSLWLTENYVIIPES 307
4OU9_A   253 NVTlnglpYLF--------GlrGAGECV-QFHPDKPAQIILVPRD-----Gge---ikRIPv-----qAGF-VFHHANAF 309 Synechocystis sp. P...
CCE29580 303 TSH-----YGWnglkvlweR--NIIEAIkPFDTNEDCKWLVVDRRh----GrgvvarfSTP-------ASF-FFHTINAF 363
EGX90311 408 TTH-----LGWngtkilweQ--SVLEAIrPFDENTPCRWLVVDRKg----SrgvvarfSTP-------ASF-FFHSVNSF 468
EXX76768 308 PFH-----GKNagi--nfkWsdNILDSL-TYRPEESTLFYVISRAe----Kqhv-atyRSE-------PCF-AFHHINAF 366
EPB84051 426 PIL-----ANAggv--kynWneSIMDSF-SFRPSEPTLFYVISREk----Gdvv-atyRSD-------PCF-VFNHINAF 484
EPB85659 333 PML-----ANSgav--rfaWseSILDSF-NFYPSEPTLFYVVSRKd----Kdvi-acyRSA-------ACF-SFNQVNAF 391
EIE87137 294 PML-----ANSgav--rfaWneSVLDSF-TFYPSEPTLFYVISRVd----Kevi-acyRSN-------ACF-SLNQVNAY 352
EPB86031 305 PYYysfgg-------lsaiYysSAYQTF-YWDETRHTLFHVIDRHt------------GHHvatyeadPCF-SFHTANAW 363
EIE76803 309 PLVygdqg-------lnslLqgAVLSSM-HWIDQAPLYFHVIHRNe----Gglva---------sipaPAFyTFHVANAF 367
EPB91835 308 PMVlkdrg-------anmlMngSFLSSI-SWVKDAPTYCHVIARHpvqqkEglvas--------ipvnPGFfTFHVANAF 371
4OU9_A   310 EEN--------GK--Ii-------LDSICYnslpqvdt--------------dgdfrstNf---DN-------------- 341 Synechocystis sp. P...
CCE29580 364 EEKikdengnqVTelY--------MDCIEYentnimhmlyydil-mdrngaaaqglakcG----LE-------------- 416
EGX90311 469 EEIiedennekRTdiS--------LEYVRYdntdilkglyydvvadrddaakkffftdeR----YK-------------- 522
EXX76768 367 EDD--------DDnlY--------LDIVCYdnteicy---------------dlslenlR----TGlv------------ 399
EPB84051 485 EDD--------RDgvY--------LDMICYpddtiarql------------tteylrnpS----TMqp------------ 520
EPB85659 392 EDV--------HGnvV--------IDMVCYendtiaqql-----------------stenlrhpETm------------- 425
EIE87137 353 EDV--------HGnvT--------VDMVCYeddtivhrf-----------------atekmrdaDMe------------- 386
EPB86031 364 DEDvelp-ggrKErvIy-------MDYCMYentdivdas------------felgktptGkldlDLvqparyvfdkntah 423
EIE76803 368 Ee------------vSldgelllhLDSSAFsdgdiiyqvqnfg----gtflqddlslkrTk---FHgftf---------- 418
EPB91835 372 ETKdn-----sGEtiLt-------LDCASFsdgdimhqlhsfgt--phrkgpaaekaaqTt---LNgisy---------- 424
4OU9_A   342 ----L-DPgQLWRFTI-DP-AAATVEK----------------------------------------------------Q 362 Synechocystis sp. P...
CCE29580 417 ----SaQM-YLVRHKF-TMqNLPMPHDknmysq----------------------------------------raeqvfS 450
EGX90311 523 ----KgHV-RLVRYRF-RLpRDGTLQTkeeaeta---------------------------------------tgeevlS 557
EXX76768 400 ---vElPLaEVRRYVLqNIqVESIKFSkipqatqletlqntvvg------------------lfknvqpvtyplpvanyV 458
EPB84051 521 ---sRlVAsEVRRYLLaNIeEEKITYMannslipsktsvttrifglfgkkqtpassdleynnqdqdmnkwyswmpiatyD 597
EPB85659 426 ---gKlAFsQVRRYTLnQPqQDAHKTYvannsfipsaisitsrigsvwnyvs---ggsnqpenavgssgwhawmpvigfD 499
EIE87137 387 ----RlPSsEVRRFVLaNPrHEANKIYldnnsyipsaisvtsrigtvwnyvt---gqagqpenatgsagwhawmpvvkyE 459
EPB86031 424 keehQiAPsQFRRYRLgQVpVAKPGADtwtpswsnafsn-----------------------------ltkfnkrrvasY 474
EIE76803 419 ppaqQvSFgHLTRHTL-NLnQRTAVFA----------------------------------------------------- 444
EPB91835 425 ppqqQsGFgDLVRYKL-NLdQSTTLSI----------------------------------------------------- 450
4OU9_A   363 LMVSRCCEFPVVHPQQVGRP-YRYVYM----------GAAHHStg--naPL-QAILKVDLESGTetlrsFAPHG------ 422 Synechocystis sp. P...
CCE29580 451 IPGPHVGELPAINPDRAGKA-YRYAYG----------VGNGGRg-----MFmDCLVKTDLQTRE------ALIWngp--- 505
EGX90311 558 IPAPHSGDLPIINPRMVHKP-HRYVYA----------VTGRGIs-----SFlDCLVKTDVQTRE------ALIWcge--- 612
EXX76768 459 RCLDSTLELPRINPKFHGQK-YRYVYG----------IGLSAKaatqdgqiwDSLIKCDLDTKE------VIAMwse--- 518
EPB84051 598 KRVQPSIELPQINPKFSMHK-HTIMYG----------LGFSAAsslkdgaiwDSIVKTNMDTKQ------IEASwhq--- 657
EPB85659 500 TLVETTLELPQVNPNYKMKD-YTYIYG----------LGFSATssiqegkiwDSITKINVQSQT------VVASwhe--- 559
EIE87137 460 RISEATLELPQVNPLYKMRK-YSFAYG----------LGNTGNsk-----mwDSIIKLDVNNST------VVASwhe--- 514
EPB86031 475 AVIGHDLEMPRFNPRYNMKP-YRFCWGvcesrhapsyASGSVV---------NGLIKLDLNNVYlg--pNTDQNssakiw 542
EIE76803 445 HTLAENIEFPRFHQELIGKP-YKFVYG----------CRVLDDkr------sTGLAKVDVSNQ--------SVIqhq--- 496
EPB91835 451 DTLAKNVEFPRFNQDYALKKkNRFVYG----------CQLQGFtekk--detGGLIKVDLTGQ--------SGPltfy-- 508
4OU9_A   423 ----F-AGEPIFV--PRPG----GVAEDDGWLLCLIYka---dlHRSELVILDAQDITApaIATLKLKhHIPYPL-HGSW 487 Synechocystis sp. P...
CCE29580 506 -vghS-PGEPMFIprPGG------AREDDGVIMTLVLds---ngQKSYLLCLDAENLEE--LGRAETDfPIAFTL-HGSR 571
EGX90311 613 -kghT-PGEPVFVerPGA------TEEDDGVLLSVVLdg---fsKTSYLLCLDAKSFEE--VGRAEADfPIGFGF-HGHY 678
EXX76768 519 -edcY-PSEPVFVpvPGN-----DDDEDDGVLLSVIFeg---qkVKSYLVVLDAKTLLE--KARVDLPqVIPLSFgHGSF 586
EPB84051 658 -dfcY-PSEAVFVprPSIGpe-dEVGEDEGVLISVVMns---akSTSFLLILDAGSLNV--LATADLErLVPLSFaHGSY 729
EPB85659 560 -encY-PSEAQFIpkPIKAgddkVAEEDAGVLISIVMds---arATSFVLVLNAKDLSV--LARVELNkLIPLSFaHGSY 632
EIE87137 515 -ancY-PSEAQFIpkPKDQaaekDEEEDSGVLISVVMda---arNTSFLLVLNAQDLSV--IAKSQLNkLIPLSFaHGSY 587
EPB86031 543 depgcsCAEPIFI--PNPD----GQDEDDGVVMSIVNttlqdgsESCFLLILDACSFTE--IARTTIGaFNAVTL-HGSF 613
EIE76803 497 -esgYaYSEPIFV--PHPQ----AKSEDDGVLLSLANh-----tECCYLVILNAMDMKE--LARFKIGqFTAITF-HGSF 561
EPB91835 509 -eegFnCSEPIFV--PSPT----GTKEDDGVLLSLVNn-----fDCCYFIVFDASNLKE--LARVKIGqFIAVTF-HGSY 573
4OU9_A   488 AQ 489 Synechocystis sp. PCC 6803 substr. Kazusa
CCE29580 572 IP 573
EGX90311 679 QS 680
EXX76768 587 RQ 588
EPB84051 730 RL 731
EPB85659 633 RL 634
EIE87137 588 RL 589
EPB86031 614 VD 615
EIE76803 562 VD 563
EPB91835 574 VD 575
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