5EB3


Conserved Protein Domain Family
DUF4154

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pfam13689: DUF4154 
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YfiR/HmsC-like
This family of proteins is found in bacteria and includes YfiR from E. coli. YfiR has been shown to regulate YfiN, a diguanylate cyclase and a bifunctional protein that produces c-di-GMP in response to reductive stress and then dynamically relocates to the division site to arrest cell division in response to envelope stress in Escherichia coli. YfiR may serve as a periplasmic redox sensor that regulates YfiN activity in response to reducing conditions. HmsC in Yersinia Pestis is the orthologue of YfiR from E. coli. HmsC is a periplasmic protein that interacts directly with the periplasmic domain (PD) of HmsD and causes proteolytic degradation of HmsD, which in turn negatively regulates Y. pestis biofilm formation.
Statistics
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PSSM-Id: 433405
Aligned: 117 rows
Threshold Bit Score: 44.9403
Created: 25-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5EB3_A                     17 VSQVLLGIFSY-VRWPKEpa--vLQLCvvg----------ptEYADGLLRGMVQANG----------RRVHAERRAVDN- 72  Ps...
Academia_Sinica:M5M_18870  31 TAAIILKLASLeARLQDEk---dISIWii-----------ndPALARVLEKRVGKTIg--------rSTLRAVHTDLPAg 88 
CAN90936                   53 RGAILLRSIGYeSGFASRag--tAVLAivgaesg-asaedasAMAAVLSRLAAKTTVa--------kRPASVLRVTYSG- 120
CAN91556                   35 QAEIVTRILPYdRGFPERvk-gqVSFLllsragdadsasaalQMRRALNDIGK---Vr--------dKPIRVESAEYSS- 101
WP_014427175               39 pAAIVLGIVRY-TRWPSDa---pLRLCvgeg--------sgaELRAQLERTPDPRGLeivetprhlpPPAA--------- 97  Ru...
jgi:Rahaq2_3955            90 VAQTVNGILSY-SRWPDKtssssLTLCiiq----------pvKYAALLTPDGSAFAG----------RPLKVMTLPFDS- 147
goetting:EBL_c09620        46 vnSIVNGIISY-TRWPQLng--lPRLCifs----------saTSASQLAREQNR-------------PVFTPVIVANTD- 98 
IEC:ABF-0016028            64 vRRTVSGIISY-SHWPRLtg--lPTLCvfs----------saHFVSGLTTPVDSQEK----------RLFNTVTVKDTQ- 119
Q6FED4                     19 fyALTLSIMSY-SKWPADn---vPTLCiid----------npTVANSFQSQVKQQSYsy------kiQAIPASSFSKTQ- 77  Ac...
Q1GWK9                     36 VNRMVGGIASY-VRWPSGtpatnRHMCvvg----------tpRLAPRMAPDTPGR------------GSISVRYIAASAv 92  Sp...
5EB3_A                     73 PDlg------tlCNVIYLGVV-DERERQQVFRSLAGH--P---VLSISERGTECSVGS----MFCLNVGGPRITFEANLD 136 Ps...
Academia_Sinica:M5M_18870  89 TR----------PDLVYINSQnKLPEFVARANQLG--------AISMTPF----HNGNvkdvTVLIYDDQGLPAITINMP 146
CAN90936                  121 RAqlqealraagAEVVYVARG-----LAAAIPDIPSRegAvvrIVVCGDG-DDTKRGC----AVAVGLSGAKPELLLNVK 190
CAN91556                  102 ASelaatcrardINVVYISSG-LGREVASIRGALTDT--G---ILSFAAVEPYVSQGA----VLGVDVADGKPRMSINLA 171
WP_014427175               98 ------------CSVLLFDGW-PPVAHRETLRRLAGQ--P---VLTIGWGHEFCSDGG----MFCLQRIGDRHSFEVNLD 155 Ru...
jgi:Rahaq2_3955           148 PLlt------sqCDAIYSGST-TAEQQNDLHQRLEGH--A---ILTLSEQDDACALLN----AFCLVITPLHTGFKLNLD 211
goetting:EBL_c09620        99 QAlr------enCDAVYFGHE-SVQQQIALREQYHGK--P---QLYIAEQNPDCSAGS----VFCLNITDKKISFSVNLD 162
IEC:ABF-0016028           120 EMfa------sdCDAVYFGEE-TISEQVDIASYAVGH--P---LMTIAEQSPDCHEGS----AFCLVFAGKTVGFSINME 183
Q6FED4                     78 ------------CQAVYFSNL-SPQQQQNLINSYPTR--N---VLSFSSNNSDCEIGS----IFCLYQQKGNATFKVNLD 135 Ac...
Q1GWK9                     93 n---------adCDILFLGRM-PATDRRQLIAWVRGR--P---VLTITDDDAACLYGA----MFCLSSRAASLSFSVNLD 153 Sp...
5EB3_A                    137 SIARSGVRVHPSVLKLAR 154 Pseudomonas aeruginosa PAO1
Academia_Sinica:M5M_18870 147 ASRQLNLQWDPSVLEISd 164
CAN90936                  191 HANAIGLRFDPQLLRLAR 208
CAN91556                  172 QARAQHIDFPAPILKLAR 189
WP_014427175              156 VAARSGLRVHPQVLRLAR 173 Rubrivivax gelatinosus
jgi:Rahaq2_3955           212 TLSRSGVRVNPAVLQLAR 229
goetting:EBL_c09620       163 SLSRSGVRVSPDVLMLAR 180
IEC:ABF-0016028           184 ALSRTGVRVNPDVLMLAR 201
Q6FED4                    136 SLSRSQIRIDPRVLLLAK 153 Acinetobacter baylyi
Q1GWK9                    154 AIARGPLKIDPRVLRIga 171 Sphingopyxis alaskensis
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