2PJY,1KS6,3KFD,5TX4,1PLO,1KTZ,1M9Z,4P7U,5TY4


Conserved Protein Domain Family
TFP_LU_ECD_TGFR2

?
cd23538: TFP_LU_ECD_TGFR2 
extracellular domain (ECD) found in TGF-beta receptor type-2 (TGFR-2) and similar proteins
TGFR-2 (also called transforming growth factor-beta receptor type II (TbetaR-II), or TGF-beta type II receptor, or TGF-beta receptor type II) belongs to a group of receptors for the TGFbeta family of secreted signaling molecules that includes TGFbeta, bone morphogenetic proteins, activins, growth and differentiation factors, and anti-Mullerian hormone, among others. These receptors contain an extracellular domain (ECD) that binds ligands, a single transmembrane region, and a cytoplasmic catalytic kinase domain. Type II receptors, such as TGFR-2, are high-affinity receptors which bind ligands, autophosphorylate, as well as trans-phosphorylate and activate low-affinity type I receptors. TGFR-2 acts as the receptor for TGFbeta, which is crucial in growth control and homeostasis in many different tissues. It plays roles in regulating apoptosis and in maintaining the balance between self-renewal and cell loss. It also plays a key role in maintaining vascular integrity and in regulating responses to genotoxic stress. Mutations in TGFR-2 can cause aortic aneurysm disorders such as Loeys-Dietz and Marfan syndromes. This model corresponds to the ECD of TGFR-2, which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).
Statistics
?
PSSM-Id: 467068
Aligned: 37 rows
Threshold Bit Score: 125.852
Created: 21-May-2020
Updated: 27-Apr-2023
Structure
?
Program:
Drawing:
Aligned Rows:
 
Conserved site includes 10 residues -Click on image for an interactive view with Cn3D
Feature 1:trimer interface [polypeptide binding site]
Evidence:
  • Structure:2PJY; Homo sapiens TGFBR2 in complex with TGFBR1 and TGFB3, contacts at 4A

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Feature 1         ##  # #                    ####                                                 
2PJY_B          8 QLCKFCDVRFSTCDNq---KSCMSNCSITSICEKPqEVCVAVWRKNDenITLETVCHDPklpYHDFILEDAAs----pKC 80   human
XP_006004370   30 NLCKWCDESHPTCEN----NVCKSNCNFSSFCETAeEICVTIWKEVNgsTSVRTLCHHPrvlVENVFVPHYNt----nEC 101  coelacanth
XP_005049674   28 NLCKWCDSTAPACED----KVCYSNCNLNSYCEDPyEICVAIWRQDNesIRISTLCHNPqrpIENLMVPNYNt----sRC 99   Collared flyc...
XP_004081706   28 NVCKWCLPSTPVCKD----NICLSNCNLSSYCSFTeEICIAIWRKTNetMTVHTMCHHPnlpLEGINPRLLLnft-srEC 102  Japanese medaka
XP_688938      28 NLCKWCDHSSPVCED----NVCMSNCSLTSYCFLAeEVCVAIWKKDNvsVSVRTLCYDPqhmLENIMLANYSs----kEC 99   zebrafish
XP_009292206   30 RICSSCKPHPVNCVS----NQCFSNCSVSTECVNEqDVCAAVWWRDAglVMVETLCHDPlkpMLGVMVEDILi----sEC 101  zebrafish
RXN17144       32 SVCKSCGPQPANCKS----YQCLANCSVSEVCPSPdDVCAAVWWRNNgmVTVQTKCHNPkqlLKGVMMDNYNs----sDC 103  rohu
OCT63248       11 NVCKWCDNSHPVCDG----GICLTNCSLSSYCENPeEICVTIWKEENesLQLSTRCHHPlllLENFLVPNYNt----sLC 82   African clawe...
XP_019749476   54 NVCMWCDATSPTCGErrgeRVCFSNCSLSSFCSSPhDICVALWRETNasVSVRTMCHDPtrpLEGVRAGALPlnstshEC 133  tiger tail se...
XP_028250010   30 PLCMVCDGSSPVCKA----GVCRSNCDMVAICFSYeDICVAIWRETNntVTVQTMCHNRtlpLEGVDPGLRLlnsvstEC 105  Indian glassy...
Feature 1                             ##       
2PJY_B         81 IMKEKKkpgETFFMCSCS-SDECNDNIIF 108  human
XP_006004370  102 LMTKQSteeGLLYICGCVeEHECNDKIIF 130  coelacanth
XP_005049674  100 TMSQQPsqdGLVYICGCVdEQECNDKLIF 128  Collared flycatcher
XP_004081706  103 HMLPQPadeGVMMVCGCQgEQECNDKLIF 131  Japanese medaka
XP_688938     100 LMSPHPsedGLLFICSCVgDQECNDRLIF 128  zebrafish
XP_009292206  102 VLQEQNihgRHLRVCSCT-GDQCNQNLLL 129  zebrafish
RXN17144      104 VLTIRNtdpHNLRLCACT-GRECNERMLL 131  rohu
OCT63248       83 VMSAMPsvsGRLYTCACTeEQECNDKLIF 111  African clawed frog
XP_019749476  134 RMTAAApaeGGLKVCACRgRHECNDKLVF 162  tiger tail seahorse
XP_028250010  106 HMVPQPtkeGAVMVCGCD-SDECNDEFHL 133  Indian glassy fish

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap