1YCK,2AR3,3HMB,4KNL,4BXD,4BJ4,3D2Y


Conserved Protein Domain Family
Amidase_2

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pfam01510: Amidase_2 
N-acetylmuramoyl-L-alanine amidase
This family includes zinc amidases that have N-acetylmuramoyl-L-alanine amidase activity EC:3.5.1.28. This enzyme domain cleaves the amide bond between N-acetylmuramoyl and L-amino acids in bacterial cell walls (preferentially: D-lactyl-L-Ala). The structure is known for the bacteriophage T7 structure and shows that two of the conserved histidines are zinc binding.
Statistics
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PSSM-Id: 460236
Aligned: 523 rows
Threshold Bit Score: 33.8686
Created: 4-Apr-2022
Updated: 13-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1YCK_A                        32 PLRYVVVSHT-A--Gssc------ntpAscqqqarnvqhyhmktlgwCdv---gYNFLIGEDGLVYE------------- 86   human...
WP_006718571                   7 kITLIDLHHSaGheKnt--------eeIrqyh------------kniRgygdigYSAVIESDGTVGKgrdty-------- 58   Desulfitobacterium metallireducens...
jgi:Sgly_0363                  7 sIKYIDLHHTaGneAsl--------gvIrneh------------mknNgwgdigYNAVVFPDGTIPKitnsdgscat--- 63  
BAM01024                     591 QIRYIVVNQTgAhpLlsler---varaHik----------------aGypg-iaYDFVIDAAGEILKvkdle-------d 643 
EHO42856                     181 P-TYIVIHHSgTstKasfedvvnkekqErknarga------yrldpsF-------HSVITYDGVIHNycr---------- 236 
jgi:Sinac_3381                53 tpkyVTIHHAgVlwEakv------apvAfvrnmqsw----gqkekgwPdl---pYHFLIAPDGTIFE------------- 106 
UCNUF:IALB_0975               59 KIDKITIHHGgEffSedk------dmiQylrnlqsw----srrekkwIdi---pYHFMIDLKGNIYE------------- 112 
Q3ABL1                        97 NVDYIVLHHTaAtrDl-----------Swqeinse------hkargfAgf---gYHFYINKAGIIYA------------- 143  Carboxydothermus hydrogenoformans Z-2901...
EHR72075                     183 TYDRIVVHHTd----------------Nhktikgne---esqigrgyAal---gYHFFIESDGAIFE------------- 227 
WGS:ADGE:HMPREF0389_00769T0   21 NVKYIVIHHAeAskAtw--------qdIhrw-------------hqeRgwagagYHEYITKTGEVYLlrgsetaeqckeg 79  
1YCK_A                        87 ----GRGWnftgaH--------SGh-----LWNP---MSIGISFMGNY-----MDRVPTPQAIRAAQGLLA---CG-VAQ 137  human...
WP_006718571                  59 ---------ysgaHdpglapdgSRf-----TMNQ---RAYSICHIGNFqs--pNADKMTDVQFNSSVKHCV---EK-CKE 115  Desulfitobacterium metallireducens...
jgi:Sgly_0363                 64 ----grslkwsgaHnpgkapdgSGy-----TMNQ---KAYGLSHVGNF-----ETGTMPDVQFAASTKFCA---EL-CKE 122 
BAM01024                     644 vaqpDQVW------------------------SE---QGVNICLAGRF-----DTEPPSLSQLDAAGRLCA---WL-AQN 687 
EHO42856                     237 --wdSIGW-----Hvakg----------prvsNA---NSLGLCFVGNFrnrssGKNKPSEQQIEAGARLLAlwrYL-Y-- 293 
jgi:Sinac_3381               107 ----GRPLiy-epE--------SNt----kYPLS---GNIGVEMMGSF-----EQQRPDPRQIASCVKLTA---WL-CHS 157 
UCNUF:IALB_0975              113 ----TRPIny-pgD--------TNt----dYDVT---GHALICVVGNY-----EEQKINQSQLNALVNLIS---FL-KDK 163 
Q3ABL1                       144 ----GRPLnvigaH---------Al-----GLND---ESIGICFSGNF-----EEEKPTSEQINSGKLLVS---WLkYKI 194  Carboxydothermus hydrogenoformans Z-2901...
EHR72075                     228 ----GRPLevmgsH--------AGegltpgPLNDpdfGAIGIVLRGNYdg-llGSSAPPPAQFDALRALV-------IEL 287 
WGS:ADGE:HMPREF0389_00769T0   80 vhvkG--------H------------------NR---ESYGICLEGNYn----GEQRIPYAQMEALFLRIA-------EK 119 
1YCK_A                       138 GALRsnYV-LKGH-----Rdv-------qrTLS------PGN 160  human
WP_006718571                 116 LGIIpsKAtIKEHkdq------------faTAC------PGD 139  Desulfitobacterium metallireducens
jgi:Sgly_0363                123 LNIVpsTStIRRHsdd------------yaTAC------PGK 146 
BAM01024                     688 MGLDadA--IVG------------------LGElipsdsPGE 709 
EHO42856                     294 -DIEekNV-VR-HsdvrrGk----------IIC------PGE 316 
jgi:Sinac_3381               158 YGidl--aqVRGH-----Kdaa-----sgqTDC------PGK 181 
UCNUF:IALB_0975              164 YNvad--knIRGH-----Kdyt------tqTVC------PGK 186 
Q3ABL1                       195 FNkp----kVIGH-----KevaslrptatkTAC------PGR 221  Carboxydothermus hydrogenoformans Z-...
EHR72075                     288 RKQLpgMRrLQMH-----Kevvr---kgdpTQC------PGD 315 
WGS:ADGE:HMPREF0389_00769T0  120 KKIYpkAK-IRLHkql------------ssTDC------PGK 142 
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