2WVR


Conserved Protein Domain Family
Geminin
?
pfam07412: Geminin 
Geminin
This family contains the eukaryotic protein geminin (approximately 200 residues long). Geminin inhibits DNA replication by preventing the incorporation of MCM complex into prereplication complex, and is degraded during the mitotic phase of the cell cycle. It has been proposed that geminin inhibits DNA replication during S, G2, and M phases and that geminin destruction at the metaphase-anaphase transition permits replication in the succeeding cell cycle.
Links
?
Statistics
?
PSSM-Id: 462159
Aligned: 20 rows
Threshold Bit Score: 236.563
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
?
Program:
Drawing:
Aligned Rows:
Download Cn3D
PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
2WVR_A         1 MNPSMKQK--QEEIKENIKN--------SSVPRRTLKMIQPSA-SGSLVgRENELSAGLSKRKHRN-DHL-TSTTSSPGV 67 
XP_014352040   1 MTTNMKQKfdTDKPAVNIKSffs--sstNVAPRRTLQVLQPSAtSGCLVgRVPE-SRLIPKRKLWGaEQLkTCKKANTEA 77 
XP_014331564   3 SVGNVKQR----SSNENVKSfsvpsqkvVREKRQSLQVLQHSA-VNTSL-KSAQTGKVIPKRKQWIlDQSrGSKRVKVEV 76 
5_pfamImport   1 LKPs------HQRSNENVKRlfts-qnaMGCPRPTLQVLQQSA-GNKALgRSAQAGKVVPKRKQCNaEYTrGPKRVKVEV 72 
XP_011607766   1 MSSSGKPKsgLQASNENIMSffgpsqkaMGPSRQALQLLKDSA-ANKDPgRSTQ---AIPKRKQWSaTPTrGPKRVKVEV 76 
XP_007249364   1 MNSVRKMKq-GENPQENIKKfftaqtsgASSGRRTLQVLQPST-VNKGLgRTTEIGKAVPKRKLWSvDQVkGSKRAKAEV 78 
Q1LU98         1 M-SSIRRPknAENPSENIKKflvaptsgAGMGRRTLQVLQPSA-VNKNLgRIIENGKAVAKRKMWSaEQVkGSKRVKAEV 78  zebrafish
NP_001098337   1 MTSSGKLQknHQRSNENIKTflapsqkqMEFNRKSLQILQPSA-ANTDL-RAAQAGKGIPKRKQWLaEQTrGPKRVKVEV 78 
XP_016848460  36 MNSRVKQKldAEEPITTKQAsrs--ntnSTSQRQTLKMIQPSI-TGCLVgRSNE-GKSSIKRKIWS-DQM-TSKASKPET 109 green anole
CAG11151       1 MSSSGKSTasHQSSKENIISffassqkaMGPTRQALQVLKDST-ANKDFgRSTQ---AIPKRKQWNaTQTrGPKRVKVEV 76  spotted green p...

2WVR_A        68 IV-PESsENKNL-GGVTQESFDLMIKENPSSQYW---KEVAEKRRKALYEALKENE--KLHKEIEQKDNEIARLKKENKE 140
XP_014352040  78 AVdPEH--NENViEGNQKEAYELMVKANPPSIYW---KELAEERRKALYEALQENE--RLHKEVEHKDEEILKLKKENEE 150
XP_014331564  77 KAtQTE-EVNCVpDGLSKEAYELMVKETPPSSYW---KEVAEERRKALYRVLQENE--KLHKDIEARDEEISKLQSENEE 150
5_pfamImport  73 KAtQTD-ETPCLsNDMSNDAYQLMVVETPPAAYW---KVIADERQKALYNVLQENE--KLHKDIEAKDDQITRLKCENGE 146
XP_011607766  77 KStQTE-ESQCLvGGMSVEAYDLMVREAPSDNYW---KELAEERRKALYDVLQENE--KLHKDIEAKNEQITALKSENEE 150
XP_007249364  79 AVkITDpENENLpDGISQEAFELMVKETPSSAYW---KEMAEERRKALFNVLQENE--KLHKEIETKDEQIAQLKSENDE 153
Q1LU98        79 AVkSTNaENENQpEGVTQEAYELMIKETPGSSYW---KEVAEERRKALFSVLQENE--KLHKDIEAKDEQIAQLKTENEE 153 zebrafish
NP_001098337  79 KStQTE-DDCLPpDGVSSEAYDLMIKETPPASYW---KEIAEERRKALFNVLQENE--KLHKDLEVRDEQIRKLQSENED 152
XP_016848460 110 AVeKEHiNTSVL------QASDLTTKVWKVILHlnieREVAEERRKALYEVLQ--EneKLHKEIELKDGEISRLKEENEE 181 green anole
CAG11151      77 KStQTD-ESRCLvDGISTEAYDLMVKDTPTGDYW---KELAEERRKALFDVLQENE--KLHKDIEDKNERIAALKSENEE 150 spotted green p...

2WVR_A       141 LAEVAEHVQYMAELIERLNGEPLDNFESLDNQEFD-------SEEETVEDS 184
XP_014352040 151 LVELAEHVQYMANVIERLTGQNSDTLEALKNLDLD-------EDHQDAEED 194
XP_014331564 151 LQELAQHVQYMADMIERLTGKCPESLEEMKDIAFD-------AEEADPAEQ 194
5_pfamImport 147 LQELAQHVQYMADMIERLTGASPENLEELREIALD-------VEEDGEEEH 190
XP_011607766 151 LHELAKHVQYMANMIERLTGMGPDNLEELRDMALE-------TEDTEQTGE 194
XP_007249364 154 LQELAQHVQHMADMIERLTGKSPDNLEELREMAFD-------TVVEDDDNE 197
Q1LU98       154 LQELAQHVQHMADMIERLTGKSPDNLEELREIAFD-------AEDEELENE 197 zebrafish
NP_001098337 153 LQELAQHVQYMADMIERLTGKCPDNLDELKGITLDvvdsyehAEGEAEDHS 203
XP_016848460 182 LAELANHVQYMSDMIERLTGQAPEDLETPKNLDLEgt---ayEENDSTEED 229 green anole
CAG11151     151 LRELAQHVQYMADMIE----------------------------------- 166 spotted green pufferfish
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap