4XLG


Conserved Protein Domain Family
Slx4

?
pfam09494: Slx4 
Click on image for an interactive view with Cn3D
Slx4 endonuclease
The Slx4 protein is a heteromeric structure-specific endonuclease found from fungi to mammals. Slx4 with Slx1 acts as a nuclease on branched DNA substrates, particularly simple-Y, 5'-flap, or replication fork structures by cleaving the strand bearing the 5' non-homologous arm at the branch junction and thus generating ligatable nicked products from 5'-flap or replication fork substrates.
Statistics
?
PSSM-Id: 430644
Aligned: 74 rows
Threshold Bit Score: 48.6571
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
?
Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
4XLG_B              15 FEFLTHLVKQ---EPDLLTRIYCFQPITMNDLINKLRNKdsFVD----------LID---DGTIREWTDKLGICIRS 75   [Candida] g...
XP_002118193       892 ADRISDFIKS---NRAVYMSVLKYEPLELRDLHRLLKASs-------------iKCP---RQKLPAILDQLGVMFSM 949 
FlyBase:CG8601-PE 1068 HIAWHNLICA---NPQLHESVLTYEPIDLQAVYLHLKHMg-------------hRYD---PKDLKTFFDRRCIIFRY 1125
XP_002062409      1068 HIAWHNLICA---NPQLHESLLMYEPIDLQEIYMHFKQMg-------------hRYD---PKELKSFFDRRCIIFRY 1125
XP_002046400      1071 HIAWHNLLCA---NPDLHERVLHFEPIDLQEIYLYLKQLg-------------qRYE---PKELKSFFDRRCIIFRY 1128
EDS35182           463 HIAFYNMVKA---NSTLRQRILRYEPLDLDAIVGHLKEIg-------------lRYD---SNEMIAFLDKRCIAFRS 520 
jgi:MICPUN_58401   183 EDRLGEWIKR---DDELYERILLMKTVDVDDVAAALRADggPDKenasenawtkKVP---RTKLLAYLESEGVAVVS 253 
ESS28066          2323 AEAIQAAIVD---HDQLYEKFLTHQSVALRDVYLYLRERg-------------lQVS---MASTKAYLQAAGVYFTT 2380
EAU84901           413 QKALMKKISE---DREIKLKILRYEPISLHVFHTLLIPGr-------------tKLSlkhKTMLVAFLENEGITTYD 473 
Q6CFP1             733 MSELTEFMMSapeARDMWLKMLTYQPISLSQLMEFNKEHg-------------iKIS---KVLTIAWCDLHGVTWTS 793  Yarrowia li...
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap