6MZD


Conserved Protein Domain Family
TAFII28

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pfam04719: TAFII28 
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hTAFII28-like protein conserved region
The general transcription factor, TFIID, consists of the TATA-binding protein (TBP) associated with a series of TBP-associated factors (TAFs) that together participate in the assembly of the transcription preinitiation complex. The conserved region is found at the C-terminal of most member proteins. The crystal structure of hTAFII28 with hTAFII18 shows that this region is involved in the binding of these two subunits. The conserved region contains four alpha helices and three loops arranged as in histone H3.
Statistics
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PSSM-Id: 428086
Aligned: 77 rows
Threshold Bit Score: 92.9331
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6MZD_P       108 ILVSSFSEEQLNRYEMYRRSAFPKAAIKRLIQSITGTSVSQNVVIAMSGISKVFVGEVVEEALDVC----------EKWG 177
Q6C5I4        75 ILMKNFDTEQMNRYEVFRRANINRPGVKKLANAVLNQSITANVAVVLSGISKVFIGEIIEKAKDVQlrmnpryegdDTYE 154 Yarrowia lipoly...
XP_003957609 119 LLVLNLDSEQNNRFEVFHRTSLNKSQVKKLASTVCNQTISENIRVFLQAIGKVYVGEIIELALDVR----------KKW- 187
XP_001645519 131 LLVTNLDSEQTNRFEVFHRTSLNKSQVKKLAGTVINQSVTENIRVFLQAVGKIFAGEIIELALDAR----------QKW- 199
CCE89741     124 LLVTNLDEQQTNRFEVFHRTSLNKTQVKKIAGMVINQSVTENIRVFLQAIGKLYAGEIIELALDVR----------QKW- 192
XP_002496997 143 LLVTNLDEEQTNRFEVFHRTALSKTQVKKIAGMVINQSVTENMRVFLQAVGKIYAGEIIELALVVR----------EKW- 211
XP_004180180 217 LLINNLDNEQTNRFEVFHRTSLNKTQIKKLANTVTNQNITENIRVFLQAIGKMYIDDLIEISMEVR----------NKW- 285
CCE62883     139 LLVNNLDEDQTNRFEVFHRTSLNKAQVKKLANTVLNQNISENIRVFLQSIGKVFAGEIIELAMQVR----------MKW- 207
CCE83747      93 LLIANFSNEQMERFESYRRMTVNKPGIKKVCTSVLNHSLPQNISVVLAGLSKSFLGEIITRALAVQ----------EKE- 161
CCE42017     112 LLITNFTNDQMERFEAYRRSTINKPGVKRICNGVVGHSVSQVIATVMAGVAKSFISEIISKSFEVQ----------ERD- 180
6MZD_P       178 EmP-PLQPKHMREAVRR 193
Q6C5I4       155 NaS-PLLPEHVREAWRM 170 Yarrowia lipolytica
XP_003957609 188 -----FNARMAIEFDRR 199
XP_001645519 200 -----LLSKMDIQYERR 211
CCE89741     193 -----LDGRMMIEFDRR 204
XP_002496997 212 -----FVSRSVLEFNRK 223
XP_004180180 286 -----LIGKMIIQFDYK 297
CCE62883     208 -----LVGQLTINYNKR 219
CCE83747     162 --NkAQLIKDIEEKKKQ 176
CCE42017     181 --NkGKLLSDIELKKKQ 195
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