Conserved Protein Domain Family
S100PBPR

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pfam15427: S100PBPR 
S100P-binding protein
S100PBPR is a family of proteins found in eukaryotes, and localized to cell nuclei where S100P is also present, and the two proteins co-immunoprecipitate. S100P is a member of the S100 family of calcium-binding proteins and there have been several recent reports of its over-expression in pancreatic ductal adenocarcinoma. In situ hybridization shows S100PBPR transcripts to be found in islet cells but not duct cells of the healthy pancreas. An interaction between S100P and S100PBPR may be involved in early pancreatic cancer.
Statistics
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PSSM-Id: 464711
Aligned: 12 rows
Threshold Bit Score: 571.43
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_008271965  21 NASFS-WS--SLDEEELDDSLLELSDGEEDDGHFSYTEEEIQELLKDDDPSD---VCGEGLYKDDGGHVE--NGGKGNQI 92 
ELW48616      21 SAPFS-SS--SLDEDGLDDSLLELSDGEEDDGHFSYTEEEIEELLKDDDLLDehiPREAGLCKDDSGRDE--KGERGGHI 95 
XP_005617682  21 NAPFS-WG--SLDEDGLDDSLLDLSEGEEDDGHFSFTEEDIQELLKDDDLSNehfSWGGGLLKDN-RHVE--KGGKGNEI 94 
Q3MHH3        21 NAPFS-WS--SLDEDELDDSLLELSDG-EDDGHFSFTEEQIQELLKDDDLSNehfPWGGGLPSDDSRNVE--KGEKGSQI 94  cattle
XP_003765483  29 NVPISsWGrfGLDEDGLDDSLLELSEGEEDDGHFSYTEEEIQELLKDDDSLNeqsL--GGLRKDTGGDPE--KLGSCSCA 104
XP_016814038  21 gAPFS-WD--CLDEDGLDDSLLELSEGEEDDGDVNYTEEEIDALLKEDDPSYeqsSGE-----DDGGHVE--KGERGSQI 90 
XP_006239018  21 NASFS-WG--SSDEDELDDSLLEFSDGEEDDGHFSFTEEEIEMLLKDDD----------------GGHNE--YRARKSQI 79 
XP_013219442  21 tAPFS-WG--SLDEDELDDSLLELSDGEEDDDNFNYTEEEIDELLKDDDPSDehfSLEERLCKDDGRHVE--NGGKGSQV 95 
EHB04568      21 NAPFS-WS--SLDEDELDDSLLELSDGEEDDGHFSLTEEEIEELLKDDSSSNeeeIEE--FLKDDEPSNEhaNGEKRSQI 95 
XP_023363539  34 NAPFS-WG--SLDDDVLDDSLLELSDGEEDDGHYSYTEEEIEELLKIDEPSSedhSWEGGLCKDESRHDE--KGERGSQI 108 small-eared galago
XP_007492960  30 DPVSS-WGrfGQDDDGLDDSLLELSEGEEDDGHFSYTEEEIQELLKDDDSLNeqslgglrkdt----ggqaeklenysCI 104 gray short-tail...
XP_003415334  21 SVPFS-WS--SMDEDELDDSLLELSDGEEDDGHFSFTEEEIEMLLQDDDLSDeqsSGRRDLLKDDSGHIE--KGERESQI 95  African savanna...
XP_008271965  93 LPDTPQEKnsNSLCSLGPVTETPGLFKLPQLNTSVGHGPTPAKPLNRRFALEKNLIKVTiVAPFNPAACDTVREKKKV-- 170
ELW48616      96 LLDIPQEK--NSLYSLGPVTETPDLFKLPQLSTPVGQRPTPNKPLNKRFILDKNLIKVT-VAPFNPTVCDAVLDNDKT-- 170
XP_005617682  95 LLDTSQEK--NSLYSLGPVAETPGLLKLPQLSTSVGNGPTPTKPLNRHFALEKNLIKITvVAPFDPTVCDAVLDKDKT-- 170
Q3MHH3        95 PLDTPQEK--DSPYNMGPEAETPDTFKLPQLTTSVGHGPTPAKSLNRRFALEKNLIKVT-VAPFDPTVCDVALDKDKTyv 171 cattle
XP_003765483 105 SFDSPQDI--NVLCSLGPRAGPASIHKLPQISTPASHAPS-----SRHFVPEKSLLKITvVPPFNSTVCDDMLGPKKTe- 176
XP_016814038  91 LLDTPQEK--NSSYSLGPVAETPDLFKLPQLSTSSGHGPAHTKPLNRRSVLEKNLIKVT-VAPFNPTVCDALLDKDET-- 165
XP_006239018  80 LPHTPQE---NSLYSLGPAAETPGFLKLPQLSPSVGHGPTPSKSLNRHFVLEKNLIKVTvVAPFNPTVCDPVLDKDKI-- 154
XP_013219442  96 LLETPQEK--NSLYNLRPVAETPGLFKLPQLSTSVGHGPIPTKPLNRRFVLEKNLIKVTvVAPFNPSVCDPVLDKDKI-- 171
EHB04568      96 LLETPQEK--SSLYSLKPVAETPGLFKLPQLNTTVGHEPIPAKSLNRHLVLEKNHIKVTvVAPFDPTVCDPVLDKSKT-- 171
XP_023363539 109 LLDTPQEK--NLLYSLGTVAETSG-FKLPQLSTSIGHGPTPTKPLNRRSAVEKNLIKVT-VAPFNPTVCDAVIDKDQT-- 182 small-eared galago
XP_007492960 105 SFDSPQDI--NVLCSTGPRAGPASIHNLPQKNIPARHAPIPTKSPSRHFVSEKNLLKITlVPPFNTTVCDA-FGPKETe- 180 gray short-tail...
XP_003415334  96 LLDAPQEK--NSLYSLGPVAETPGLFKLPQLSTSIGHGSTPTKPLNRRFALEKNVIKIT-VAPFDPTVYDAVLDKDKT-- 170 African savanna...
XP_008271965 171 --NSSKETEK-------PSPTGEEMr-nGLTPNEGEACTESEGISPSNSSWEQPQLSS--NSNVQLTVSGKNLPDCKKPT 238
ELW48616     171 --DSSKDTEK-------PSSLGEDT---SYNPDENKLCTESEDISPNNAAWDEPLFSSplNNNFQNTVSDKNIPDSKKPA 238
XP_005617682 171 --DSSKDTEK-------PSSLGEEMrkgGLSPNENKLCSESEGISPSNSAWDAPPLSSpsDNDFEQTVSDKNMPDSKRPT 241
Q3MHH3       172 seVTSRVTEK-------PSSLGEEMredDLSPNESTLCTESEGISPDNSASDGPPLPSs-NSNFQHTVSDKNMSDSKKAT 243 cattle
XP_003765483 177 --FSSKDGSSnay-ylgISSLKEDVskeDHGQNDGKLCTKE--ISSTCSVWEGPQp---hKAGPSQGAPRASGPSCEESV 248
XP_016814038 166 --DSSKDTEK-------LSSLGEEMredGLSPNESKLCTESEGISPNNSAWNGPQLSSs-NNNFQQTVSDKNMPDSENPT 235
XP_006239018 155 --DSSKETEK-------PASLQEQTredDLHPNESKRCTEPEGVSPNNSAWDGPLLSSpsNNNIEQTASDKNIPESKKPT 225
XP_013219442 172 --DSSKDTEK-------PSSLEEGMredGLNPNESELCTESEEMSPNNSAWDGSLFSSplNNNFQQTISDKNTPDSKKST 242
EHB04568     172 --DSSKDTEK-------LSSLGEEMreyDLTPNESKVHTESEEISPNISAWDG--ISSplNSNFQQTVSVKNTLDSKKPT 240
XP_023363539 183 --DSSKDTEK-------SSSLGEKLkedGLSSNESKLCTDSEGIRPSNSAWERPSLSStsNNTFQQTVSDKAVPNSKKPT 253 small-eared galago
XP_007492960 181 --SSSKDGSSnanclgtPSSLEKDVnreGHGQNDGKLCTKE--ISSACSVWKGTPp---pKAGPPQGPPRANTPICEESV 253 gray short-tail...
XP_003415334 171 --DSSKDIKK-------PSSLGEELredGLNTNESKLCTESEVISPTNSAWDGHTFPSpsNNNFQETVSDKNMPDSKKPT 241 African savanna...
XP_008271965 239 PVFSQLSDHPETPN-AESPWRNGGSHRSSCEVKFS-VSSSPNKD-VFDKDSGKVKVHEKRLGKVIPVLQTKTRTNVSTFS 315
ELW48616     239 SVFSQISDHSETPFnTGSSWRNGTSHKSSCEVRFPvISNSSNKD-IPDKVSGKVKVSERRLGKVTPVLQTKTRTNVTTFS 317
XP_005617682 242 PVFSQILDHSETPN-TGSSWKN-GSHKSNCEVRFPvVSSSSNKQdVLDKDSGKLKVNERRLGKVIPVLQAKRRTNVPTFS 319
Q3MHH3       244 PVFSQILDHSETPN-TGSSRRN-GSYKSSFEMKLP-VSSSSSKD-VLDKDSGKLKVHEKRLGKVIPVLQAKTRTNVPTFS 319 cattle
XP_003765483 249 PLASPTLEQSQRQE-VALSSGNGG-HKLGD------ASVHSTKLvRLDMDSEQKEGYERRLGKVIPLLQARARSKIQTFS 320
XP_016814038 236 SVFSRISDHSETPN-MELSCRNGGSHKSSCEMRSLvVSTSSNKQdVLNKDSGKMKGHERRLGKVIPVLQTKTRTNVPTFS 314
XP_006239018 226 PVFSQISNHSEVPN-----RKNSGSHKSGCEVRIPvVSSSSNRH-AFDKDSGEAKG-ERRLGKVIPVLQTRTR----MFS 294
XP_013219442 243 PVFSQISEHSETPN-MGSSWKNGGSQKSSCEMRFPvVSSSSNRD-ILDKDSGEMKVRERRLGKVIPVLQTKTRTNVSTFS 320
EHB04568     241 PVFSQISDHSKTPSsTSSSWKNSGSHKLSCEMRSPvVSSSSKRD-AFDKDSGEMKGREKRTGKVIPVLQTKIRTNVSTFS 319
XP_023363539 254 PAFSQISDHSETPS-VGSSWRNGGSHESSGEMKFPvSSSSNk--dVLDKDSGKIKGNERRLGKVIPVLQTKARTNVPTFS 330 small-eared galago
XP_007492960 254 PVASPTLGPTPRPD-VALSSGNDG-HKLGDTARSPaVQSSSTKPvKLDKDSKKKEGYERRLGKVIPLQLakarskiqTFS 331 gray short-tail...
XP_003415334 242 PVFSQVLDHSESSSyMGSSYRNGGSHKSSCEVRFPvVSS---KQhVLDKDSGKMKVHERRLGKVIPVLQSKTRTNVPMCS 318 African savanna...
XP_008271965 316 QSDLEQQKQIYLRRVIAHIQDPVDSNQGALGELYALMDQV----HHMQNPKRQHPSDLTMRNYARYRQNPPQRYSLTQWV 391
ELW48616     318 QSDLEQQKQIYLRSVIAHIEDPVDSNQGPLGELCALMDQV----HYTKNQKWQHPSDLTVRNYARFRQKPLQRCSLTQWV 393
XP_005617682 320 QSDLEKQKESYLKEVIAHIEHPKDTNQGALGELYALMGQV----HHMQNPKWQHPSDLTMRNYARFRQKPLQRYSLTQWV 395
Q3MHH3       320 PSDLEKQKQSYLRNVIAHIEDPVDSNQGTLGELCALMDQV----HHMHNQKWQHPSDLTRRNYARFRQKSLQRYSLTQWV 395 cattle
XP_003765483 321 QTELEQKKQIYLKNVIAHLKHPLESNQGTLGEFYALMDQVanveYHMQHQRWQHPSDLTMRNYPRFRQKPLLRYSLTQWV 400
XP_016814038 315 QSNLEQQKQLYLRSVIAHIEDPEDTNQGVSGELCALMDQV----HHMQHSKWQHPSDLTTRNYAR-RQKHLQRYSLTQWV 389
XP_006239018 295 QSDLEKQKDIYLSKVIAHIEDPGDSNQGALGELDALMDQV-----HMQNPDWQHPSDLTTRNYARFRQRPLQRYSLSQWV 369
XP_013219442 321 QSDLEQQKQIYLRSVFDHIEDPGDSNQGTSGELYALMNR-------------QHPSDLTMRNYARFRQKPLQRYSLNQWV 387
EHB04568     320 QSDLEQQKQIYLRRVFDHIEDPGDSNQGPSGELYTLMDR-------------QHPSDLTMRNYARFRQKPLQRYSLTQWV 386
XP_023363539 331 QSNLEQQKQIYLRSVIAHIEDPEDSNQGPWKELYTLM-EV----HHMQNPKWQHPSDLTMRNYAR-RQKPLQRYSLTQWV 404 small-eared galago
XP_007492960 332 KTELEQKKQIYLKNVIAHLKNPLESNQGALGELCALMDQVangeYQKQNQRWQHPSDLTMRNYPRFRQKPLQRYSLTQWV 411 gray short-tail...
XP_003415334 319 QSDLEQQKEIYLRSVIAHIEDPVDPNQGALGELHALMDQV----HHTQNQKWQHPSDLTMRNYARFRQKSLQRYSLTQWV 394 African savanna...
XP_008271965 392 DWNKRSYHRFQH 403
ELW48616     394 DRNMRSYHRFQR 405
XP_005617682 396 DRNMRTHHRFQR 407
Q3MHH3       396 DRNKRSHHRFQR 407 cattle
XP_003765483 401 DRNLRSHRRFQG 412
XP_016814038 390 DRNMRSHHRFQR 401
XP_006239018 370 DRNKRSHHRFQR 381
XP_013219442 388 DRNKRSHHRFQR 399
EHB04568     387 ERNKRSHHRFQR 398
XP_023363539 405 DRNMRSHHRFQR 416 small-eared galago
XP_007492960 412 DRNLRSHRRFQG 423 gray short-tailed opossum
XP_003415334 395 DRNMGSHHRFQH 406 African savanna elephant
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