2WTK


Conserved Protein Domain Family
Mo25

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pfam08569: Mo25 
Mo25-like
Mo25-like proteins are involved in both polarised growth and cytokinesis. In fission yeast Mo25 is localized alternately to the spindle pole body and to the site cell division in a cell cycle dependent manner.
Statistics
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PSSM-Id: 462522
Aligned: 118 rows
Threshold Bit Score: 170.762
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2WTK_A         4 PFGKs-------HKSPADIVKNLKESMAVLEK--QDISDKKaEKA-TEE----VSKNLVAMKEILYGt-nEKEPQ-TE-- 65 
EFJ32642       5 FFKPf------rPKSAAELVKSTRDALAALDDktVADVRLL-DKA-LEE----VDKNLLAMKHMILGd-gEAEPS-PD-- 68 
EDQ55343       5 FFKQl------kPKTPAELVRQVKDSLSSLDTktMGDTRLL-EKS-LEE----VDKSIKVMKDLLLGd-tDTEPN-AE-- 68 
XP_001708185   1 --------mnrkRSSVSDLVVAIAKMLSGRTE---QASFKE-AD--AEA----LKVSISQLKSQVTS------PN-PQlq 55 
XP_001314990   3 WFTK---------AQAKGFPKRLRMALESME-----LHQNN-DT--IND----VKLYVSKITDTLNVd--SYN---RE-- 54 
EAY20933       4 WVTK---------AKRKGLAKKLRICLESIR-----VSQTA-QK--YKQ----LTPILDQINETFIQp--EFQ---QD-- 55 
XP_001314839  22 WFGQ---------MKPARIVQKAIDGLKNYM----QENNTK-EK--KAEflaiIDKNFGRMTDILYKr-kEGDEA-SS-- 81 
A8X6J7         7 rtqianpminavGETAEQAVKKLEKVFEVLK-------DRN-ERfpLTE----ISKQIDVIWESVFSvthATAPQ-KK-- 71  Caenorhabditis ...
Q4E0T3         9 RSSKgflqflrsTEDPMIVDANLLLLLQDLS------------------------------------------SPtEDai 46  Trypanosoma cruzi
Q584R2        12 vpnerlphilssSDDPTEVNKALVVLLRRLR------------------------------------------AGaGEpi 49  Trypanosoma brucei
2WTK_A        66 -AV-AQLAQELYNS-GLLSTLVADLQLIDFEGKKDVAQIFNNILRRQIGTRTP--------------------------- 115
EFJ32642      69 -LV-VQLVAEVCKD-DFLEILIHKLPNLGWEARKDTVQVWCILLRQK-GGL----------------------------- 115
EDQ55343      69 -VV-AEVIQEACKI-DVLELIVQKIPTLDWEARKDCVHIWCAVLRIKVGAVQY--------------------------- 118
XP_001708185  56 rAHyNEFTRVIMTD-NTLVDIVGGLAWLDFDSRKSLISLVAGLAHR-ASSGDPadda----------------------- 110
XP_001314990  55 -NLpHIINKKLYRD-KTVANILKFMPYFDQTMNNSVSTLLQSSIREDPTDSLP--------------------------- 105
EAY20933      56 -DLpHILNGKIYRD-HTVAMLIGLLPFFDQPTINAISTLFQTTIREFPDESLP--------------------------- 106
XP_001314839  82 -RA-LQLVTEISHT-DFVMLGLDAMPFLPVEQRKQFTIIFTGAISHQTGSEFP--------------------------- 131
A8X6J7        72 ----YELAEEFLNHpGVVKNLLMVFDGVQVETKRKIRDLLIFIRTW-TSNDFLadaegslvpnprq-----------arp 135 Caenorhabditis ...
Q4E0T3        47 sLSsAGLF-------HLLQVLVERTNDDWLEVRKKIAFVFSDLISKGHGDVLAdaliygrlekttsgeara-shidlrds 118 Trypanosoma cruzi
Q584R2        50 sLSpATLS-------QLLRILVGRTDDAWLEVRKKIAFVFSELLSKDNADVLAdallygrlhtttssearasridfggvd 122 Trypanosoma brucei
2WTK_A       116 ---------TVEYIcTQQNILFMLLKGYE-SP-EIALNCGIMLRECIR-HEPLAKIIL-WSE------------------ 164
EFJ32642     116 ---------AVHCLeNHPELLDFLISCYQ-NK-DTALNCGVMLRECSR-FASLAAYML-ESA------------------ 164
EDQ55343     119 ---------GLEYLeSHTELLDYLVLCYE-NK-EVALNCGTMLRECAR-YPTLAKYML-ESV------------------ 167
XP_001708185 111 -----dpalLVNYIlSHQDLLDVLLDGYK-LP--QPFHVTTILCEYIKvYSIAETILLfCAK------------------ 164
XP_001314990 106 -----------KYLiNHKEALDTLLSYLS-IP-KLSSIANILIRECIR-NESFVSYLFeYQY------------------ 153
EAY20933     107 -----------KYLiEHTETLDQLLSYFN-QP-NISNSAHIILRSCAI-VTDFTRFLFqNGC------------------ 154
XP_001314839 132 ---------LAIYVqRYPETLDILLKFYD-TP-ELAASTGEMLRLCAH-HETLAKQLLqPAR------------------ 181
A8X6J7       136 sqkfqdvlyECRFI-----MLHIVHEGYAgS--DSIGLYNDIIRIFAE-DDACLMFML-KDKgtdsnevk--------qk 198 Caenorhabditis ...
Q4E0T3       119 ceensdpaaALRQL---KYFIGKLAFAHG--TvERCVPAADVFRTFMR-VPSFLEIILsPAElssdtteertsphpqp-k 191 Trypanosoma cruzi
Q584R2       123 ensapdpftSLKKM---KEILGKLAEAHG--TvERCVPAADVFRTFLR-LPALLEVIMsPEPlfdvedndgsapahhatk 196 Trypanosoma brucei
2WTK_A       165 ------Q-FYDFFRYVEMSTFDIASDAFATFKDLLTRHKLLSA-EFLEQHYDRFFS--EYEKLLHSENYVTKRQSLKLLG 234
EFJ32642     165 ------S-FELFFKLVELPNFDIASDAFTTFKELLTRHGSVVN-NYLNSHYDQFFE--LYERLLSSSNYVTKRQSLKLLG 234
EDQ55343     168 ------S-FEMFFKFVETPNFDVASDAFATFKELLTRHNSVVV-AYLTSRYASFFA--NFDKLLRSTNYVTRRQSLKLLS 237
XP_001708185 165 ------EqFQRIFSAMSSPNFDVSSDASVVLKDLLTKHEQLTA-TFLDQNPQ-FFT--WFCTLLHSSNYATRRFSLNLLS 234
XP_001314990 154 --------VSSFIIYLLGDNFEMVTNAFKTYEEMLNSQISVSS-AYILSHYDIFSL--HFKQLLRSNVYIVSLLSIPLIL 222
EAY20933     155 --------VGSFVQYLSSDNFDHLSTAFATYECLLMIHPDVTA-EYFSVKWQIFAI--QIKQLMSSPNYLVQLTFLPILF 223
XP_001314839 182 --------LDLLFTYFTVPHFDVSADSFATFRELIL--CSPNAeDYIKDNAQQITDriHGT--LDEKNYAACRQSLKLIG 249
A8X6J7       199 fegcvwAiFDRLFNTHTYRGFHILAEIFETFEIIFSQNHEASQ-YFFYNNLSRFSQ--SFHWLIAANNFFIQTKSLRFVR 275 Caenorhabditis ...
Q4E0T3       192 qygfhescigilcrSVASYTTVLCTETWRSLTTALYTNKGLSA-SLLLYYFNEFVA--MLVGCLLGRNFVAKLHALELLA 268 Trypanosoma cruzi
Q584R2       197 krcfndtcigilcrSAQAYTTALCTETWRSLSTALCTNKALSA-PLLLCYFNEFVG--MFLGCLEGDNFVAKLHALELID 273 Trypanosoma brucei
2WTK_A       235 ELLLDRHNFTIMTKYISKPENLKLMMNLLRDKSRNIQFEAFHVFKVFVANPNKTQPILDILLKNQAKLIEFLSKF-QNDR 313
EFJ32642     235 DFLLDRSNTQVMLRYISDKRNLLIVMTLLKDPSKSIQSSAFHIFKVFVANPKKPAPIVHVLAKNRDRLLRFLDNF-HLDK 313
EDQ55343     238 DILLERSNSAIMMLYISDVRNLRVMMTLISDPSKNIQASAFHVFKVFVANPQKPPQIINILAKNRERLLRFLDNF-HIDK 316
XP_001708185 235 TLLLNRANFNAMSRFVESDENLKLIMRLLKDDSAVIRFEAFHVFKVFVANPKKTEPVHKILKRNKDKLIEHLLSF-TTET 313
XP_001314990 223 NFITREECRPILMYFVNDPYNLECICRHLESRSKKVRSNAYSIFKLFVINPHRTQLIRTELHENKTKLIRLIQKV-QLPD 301
EAY20933     224 RFITNESCKSIFFRFLDDSENLQLIMCILKRNSKKIQMHAYSIFKLFILNPRKAPPIVNLIKNNRSQLIKYLKDF-NFDE 302
XP_001314839 250 EIIMTYPSYQQF--YLRNEKNLMTMMKLMSSQYKNLSMEAFHIFKLFVAIDDKPEPILKILRANSEKLKVFIKGL--LDG 325
A8X6J7       276 DIFSNRYMAEVRRQWMADPSLIKYVFLHLQSIHKTVCLEAVGLLNIFVQNPCNAPPIHKLISINRKLLLEYCRQNaPNPK 355 Caenorhabditis ...
Q4E0T3       269 SVVEDPVFLRARRKFAESPALLCALLPLTNSSSAHIRFLTFETLKVFIAKGNKPAPIRHILCINRDMLARYVEDY-STKE 347 Trypanosoma cruzi
Q584R2       274 AILEDAAFLKARPKLAESPALLCALLPLTNSRSQHIRFLTFDAIKVFIAKGNKPAPIRYILYINRETLARYVEDY-SPNE 352 Trypanosoma brucei
2WTK_A       314 t-E---DEQFNDEKTYLVKQIRDLK 334
EFJ32642     314 --E---DEQFEEEKELLVKEIEALA 333
EDQ55343     317 --E---DEQFDEEKELLVKEIEGLP 336
XP_001708185 314 --N---SSDFEEEKGFIVDSISEL- 332
XP_001314990 302 ------DEELLNERRSVISnl---- 316
EAY20933     303 --N---DVELENEKQTLISTIANM- 321
XP_001314839 326 i-E---DAELQREKDYLLMELAYLK 346
A8X6J7       356 deNqalDELFDETITYLVnwneeep 380 Caenorhabditis briggsae
Q4E0T3       348 iaI---NKRLEVEKQKLLQSLTSLE 369 Trypanosoma cruzi
Q584R2       353 atI---GKVLSAEKEKILRSLLSLE 374 Trypanosoma brucei
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