Conserved Protein Domain Family
Peptidase_A22B
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pfam04258: Peptidase_A22B 
Signal peptide peptidase
The members of this family are membrane proteins. In some proteins this region is found associated with pfam02225. This family corresponds with Merops subfamily A22B, the type example of which is signal peptide peptidase. There is a sequence-similarity relationship with pfam01080.
Links
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Statistics
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PSSM-Id: 282158
Aligned: 14 rows
Threshold Bit Score: 278.032
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
P34248 145 KSKRFFDM------MDEKHAIILPLTSGCTLLALYFVIKKLhlnwLKYvv------------------------------ 188 Saccharomyces cerevis...
P49049  55 KKRLIEGS------ITMREARKFPISASLVLFGLYLFFKPAaerfLWVarvfqilrvpeeyvqkinstiisytanttttg 128 Caenorhabditis elegans
O81062  47 KDTPPTET------MSKEHAMRFPLVGSAMLLSLFLLFKFLskdlVNA-------------------------------- 88  thale cress
Q9VPQ7  71 STGEKADT------MTKKDAMYFPLIASAALFGLYLFFKIFqkvhINY-------------------------------- 112 fruit fly
Q9D8V0  62 SSSDMPET------ITSRDAARFPIIASCTLLGLYLFFKIFsqeyINL-------------------------------- 103 house mouse
Q9UTA3  31 QL------------INKRLAVLFPIFGGVTLVLMYLALRYLskeyIQL-------------------------------- 66  Schizosaccharomyces p...
Q9MA44 240 GAEEETLD------ISAMGAVIFVISASTFLVLLFFFMSSW----FIL-------------------------------- 277 thale cress
Q0WMJ8 241 TSSRGVVE------VTVISAILFVVVASCFLIMLYKLMSFW----FIE-------------------------------- 278 thale cress
Q8W469 242 GGS-GVVE------INSISAIFFVVLASGFLVILYKLMSYW----FVE-------------------------------- 278 thale cress
Q93346 275 SPSNDSETkgfldrFGGIITICLMMTTLCGVLLLGYFFRPV----LVI-------------------------------- 318 Caenorhabditis elegans

P34248 189 ------------------------------------------kILNFNITLLNIPAGTFVYSYFLNs--LFRNLSHLASW 224 Saccharomyces cerevis...
P49049 129 psepfllrlasripqervpeaiqnaatyaytnlptiqkaecmqLLTFLICFEGVNAFASLLKPFVT---AFLKKMPLVPS 205 Caenorhabditis elegans
O81062  89 -------------------------------------------VLTAYFFVLGIVALSATLLPAIRr--FLPNPWNDNLI 123 thale cress
Q9VPQ7 113 -------------------------------------------LLTGYFFVLGVIALAHLLSPVINs--LMPAAVPKVPF 147 fruit fly
Q9D8V0 104 -------------------------------------------LLSMYFFVLGILALSHTISPFMNk--FFPANFPNRQY 138 house mouse
Q9UTA3  67 -------------------------------------------ILQGYASLASIICFVRSFNPKTT-------------- 89  Schizosaccharomyces p...
Q9MA44 278 -------------------------------------------ILTIFFVIGGMQGMHNINVTLITr--R-CSKCGQKNL 311 thale cress
Q0WMJ8 279 -------------------------------------------VLVVLFCIGGVEGLQTCLVSLLScfrW-FRRFGESYV 314 thale cress
Q8W469 279 -------------------------------------------LLVVVFCIGGVEGLQTCLVALLSr--W-FQRAADTYV 312 thale cress
Q93346 319 -------------------------------------------FFNIFLVIFGTCSLYGCIRGFLSn--FKFVGHRWYNA 353 Caenorhabditis elegans

P34248 225 NplvvlpryrvtiaddnedlnkiggfvtnlnykdgLTNSVvhkktldeiekdhwmkhfyrrelvepkdikskrqisnMYL 304 Saccharomyces cerevis...
P49049 206 F----------------------------------LRFNApylfslkkgnkemeeg------diedakkketeylfkIDF 245 Caenorhabditis elegans
O81062 124 V----------------------------------WRFPYfks--------------------------------leVEF 137 thale cress
Q9VPQ7 148 H----------------------------------ILFTKgegkhk--------------------------edivnYKF 167 fruit fly
Q9D8V0 139 Q----------------------------------LLFTQgsgenk--------------------------eeiinYEF 158 house mouse
Q9UTA3     --------------------------------------------------------------------------------     Schizosaccharomyces p...
Q9MA44 312 K----------------------------------LPLL--------------------------------------GNT 319 thale cress
Q0WMJ8 315 K----------------------------------VPFL--------------------------------------GAV 322 thale cress
Q8W469 313 K----------------------------------VPFL--------------------------------------GPI 320 thale cress
Q93346 354 K----------------------------------MEWFPtcg-------------------------------griHQY 368 Caenorhabditis elegans

P34248 305 NSALIVSFVLSIVSTVYFYLSPNd---WLISNAVSMNMAIWSIAQLKLKNLKSGALILIALFFYDICFVFG--------T 373 Saccharomyces cerevis...
P49049 246 DRYDIIALLMCSPILISHLLKRH----WITNNIIGVSFSILGIERLHLASFKAGSLLLVGLFFYDIFWVFG--------T 313 Caenorhabditis elegans
O81062 138 TKSQVVAGIPGTFFCAWYAWKKH----WLANNILGLSFCIQGIEMLSLGSFKTGAILLAGLFFYDIFWVFF--------T 205 thale cress
Q9VPQ7 168 STHDIVCLVISSAIGVWYLLKKH----WIANNLFGLAFAINGVEMLHLNNFVTGVILLSGLFFYDIFWVFG--------T 235 fruit fly
Q9D8V0 159 DTKDLVCLGLSSVVGVWYLLRKH----WIANNLFGLAFSLNGVELLHLNNVSTGCILLGGLFIYDIFWVFG--------T 226 house mouse
Q9UTA3  90 -FGKITATMSSIAIALFYFKTKH----WMASNILAWALAANSISIMRIDSYNTGALLLGALFFYDIYFVFG--------T 156 Schizosaccharomyces p...
Q9MA44 320 SILSLVVLLFCFVVAILWFMNRKtshaWAGQDIFGICMMINVLQVARLPNIRVATILLCCAFFYDIFWVFIspl--ifkQ 397 thale cress
Q0WMJ8 323 SYLTLAICPFCIAFAVFWAVKRQysyaWIGQDILGISLIITVLQIVRVPNLKVGFVLLSCAFMYDIFWVFVskw--wfrE 400 thale cress
Q8W469 321 SYLTLAVSPFCIVFAVLWAVYRVhsfaWIGQDVLGIALIITVLQIVHVPNLKVGTVLLSCAFLYDIFWVFVskk--lfhE 398 thale cress
Q93346 369 KYSEAFIGIICLSFCVTWFIIRRqpyaFILLDVINMALCMHVLKCLRLPSLKWISILMLCMFVYDAFMVFGtpymttngC 448 Caenorhabditis elegans

P34248 374 DVMVTVAT-----------------------NLDIPVKLSL----PV---KFNTAQNNFNFSILGLGDIALPGMFIAMCY 423 Saccharomyces cerevis...
P49049 314 DVMTSVAK-----------------------GIDAPILLQF----PQd-iYRNGIMEASKHSMLGLGDIVIPGIFIALLR 365 Caenorhabditis elegans
O81062 206 PVMVSVAK-----------------------SFDAPIKLLF----PT-------GDALRPYSMLGLGDIVIPGIFVALAL 251 thale cress
Q9VPQ7 236 NVMVTVAK-----------------------SFEAPIKLVF----PQd--LIENGLNASNFAMLGLGDIVIPGIFIALLL 286 fruit fly
Q9D8V0 227 NVMVTVAK-----------------------SFEAPIKLVF----PQd--LLEKGLEADNFAMLGLGDIVIPGIFIALLL 277 house mouse
Q9UTA3 157 EVMVTVAT-----------------------GIDIPAKYVL----PQ-------FKNPTRLSMLGLGDIVMPGLMLALMY 202 Schizosaccharomyces p...
Q9MA44 398 SVMIAVARgsk------------------dtGESIPMLLRI----PR------LSDPWGGYNMIGFGDILFPGLLICFIF 449 thale cress
Q0WMJ8 401 SVMIVVARgdr------------------sgEDGIPMLLKI----PR------MFDPWGGYSIIGFGDIILPGLLVTFAL 452 thale cress
Q8W469 399 SVMIVVARgdk------------------sgEDGIPMLLKI----PR------MFDPWGGYSIIGFGDILLPGLLIAFAL 450 thale cress
Q93346 449 SVMLEVATglscaakgknkgypvppieqesvPEKFPMLMQVahfnPMnecLDMEIELGFQFTILGLGDIVMPGYLVAHCF 528 Caenorhabditis elegans

P34248 424 KYDIWKWHLDHDdtefhflnwsyvgKYFITAMVSYVASLVSAMVSLSIFN-TAQPALLYIVPSLLISTILVACWNKDFKQ 502 Saccharomyces cerevis...
P49049 366 RFDYRVVQTTAEskapqg--slkgrYYFVVTVVAYMAGLFITMAVMHHFK-AAQPALLYLVPCCLFVPLLLAVIRGELSA 442 Caenorhabditis elegans
O81062 252 RFDVSRRRQP---------------QYFTSAFIGYAVGVILTIVVMNWFQ-AAQPALLYIVPAVIGFLASHCIWNGDIKP 315 thale cress
Q9VPQ7 287 RFDDSKKRKTR--------------IYFYSTLIAYFLGLLATIFVMHVFK-HAQPALLYLVPACMGTPLLVALIRGELKV 351 fruit fly
Q9D8V0 278 RFDISLKKNTH--------------TYFYTSFAAYIFGLGLTIFIMHIFK-HAQPALLYLVPACIGFPVLVALAKGEVAE 342 house mouse
Q9UTA3 203 RFDLHYYINSTSqpk-------khsTYFRNTFIAYGLGLGVTNFALYYFK-AAQPALLYLSPACIVAPLLTAWYRDELKT 274 Schizosaccharomyces p...
Q9MA44 450 RFDKENNKGVSN-------------GYFPWLMFGYGLGLFLTYLGLYVMNgHGQPALLYLVPCTLGITVILGLVRKELRD 516 thale cress
Q0WMJ8 453 RYDWLANKRLKS-------------GYFLGTMSAYGLGLLITYIALNLMDgHGQPALLYIVPFILGTLFVLGHKRGDLKT 519 thale cress
Q8W469 451 RYDWLANKTLRT-------------GYFIWAMVAYGLGLLITYVALNLMDgHGQPALLYIVPFTLGTMLTLARKRDDLWI 517 thale cress
Q93346 529 TMNGFSERVRL--------------IYGFISVVGYGIGLIVTFLALALMK-TAQPALIYLVPSTLFPIIMLALCRGEFLK 593 Caenorhabditis elegans

P34248 503 FWNFQYDT 510 Saccharomyces cerevisiae S288C
P49049 443 LWNYDESR 450 Caenorhabditis elegans
O81062 316 LLAFDESK 323 thale cress
Q9VPQ7 352 LFAYEDHP 359 fruit fly
Q9D8V0 343 MFSYEESN 350 house mouse
Q9UTA3 275 LFSFRSET 282 Schizosaccharomyces pombe 972h-
Q9MA44 517 LWNYGTQQ 524 thale cress
Q0WMJ8 520 LWTTGEPD 527 thale cress
Q8W469 518 LWTKGEPE 525 thale cress
Q93346 594 IWNGVPVE 601 Caenorhabditis elegans
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