Conserved Protein Domain Family
C5-epim_C

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pfam06662: C5-epim_C 
D-glucuronyl C5-epimerase C-terminus
This family represents the C-terminus of D-glucuronyl C5-epimerase (EC:5.1.3.-). Glucuronyl C5-epimerases catalyze the conversion of D-glucuronic acid (GlcUA) to L-iduronic acid (IdceA) units during the biosynthesis of glycosaminoglycans.
Statistics
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PSSM-Id: 461978
Aligned: 14 rows
Threshold Bit Score: 191.026
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EDK33137     249 MD-SIGAIRYDFNYKHYLDDNefq-pgwISAMAQGQALSVFSRAYHLTGNKKYISAGNLALNFLTTKTSQGGPMDNLSFl 326
Q8RBZ5       108 QD-ELGGWDVFERIGSKKFYK-------YSAMTQGEGASLLIRAFQESGDEEFVDRAKKAIDLMLLPVEKGGTARYVND- 178 Caldanaerobacte...
O26430       215 RGmKYAVFPMYFDYCGsga-------gwLDSFAQGNLAGHYARAYRLTGDPEYLKISDALINSFRAPA---GLVKSTKY- 283 Methanothermoba...
Q58528       127 KNiTFIVWRYNFEFPLYNlsk-----gwRGALCQAGCLKTLYLAYEATGDERYLNYANLAINAFKVPVEKGGLLKIRIYk 201 Methanocaldococ...
WP_012109316 101 DN---GDWGGVYCYNELYGSGynlpnpwLSAMSQGFILSVFYEAYILTDKIDYLHMAEKVLNSFDIYSENGGFKSDWGT- 176 Campylobacter h...
EDK32457     213 QS-PSGAMRLDFSFKHYINNDiyk-pgwVSSLAQGQAISAFVRAYQVTGDNKYLDAADKAYMFMCIPVNEGGTKDTSEDl 290
EDK33052     174 KD---GSFRYEFKYHHYEPldv----gwTSSMSQGQALSLFARAYNLTKDVKYLNSGGRVLKYLLTPISKGGVMDNLETl 246
EDO47868     320 QD-KNGGWPITVKRKIMEGVEmap--gwYSAMAQGQAMSLLTRAYYHTNNSVYLEAALKATSLFGVPANKGGVRAMFMDk 396
O18756       416 QD-EKGGWPIMVTRKLGEGFKsle-pgwYSAMAQGQAISTLVRAYLLTKDHIFLNSALRATAPYKFLSEQHGVKAVFMNk 493 cattle
Q29RD8       384 QD-EHGGWPIKVTRKLGEGFKsle-pgwYSAMAQGQAMSTLVRAYLVTHNPSYLGAAIRATSPFKRTPEQHGVKATFMNk 461 zebrafish
EDK33137     327 gnqmadYIFFQLYITDPPSYTLNGHMFTLIGLYDWSni--snNKDYSDKASAYFKKGLLTLKYILPYYDIGGFVCYDlgy 404
Q8RBZ5       179 ------KLFLEEVVESKPVLILNGWIFAVFGLYDIF------KATSDGRYKEALQRTLDTLKDELYKYDTGYWSYYD--- 243 Caldanaerobacte...
O26430       284 ------GNFYLHYNFMRQHYILNAHLICTLGLHRAY------TYTGNTRALMLFREGVSTFRAMHRRFDSGRWTYYAvdg 351 Methanothermoba...
Q58528       202 n---ksYYWFPEYASENPPYVLNGFITATLWIGDFG------NKTGNADALYLYKEGLKSIKTFLPMYDAGDWSYYD--- 269 Methanocaldococ...
WP_012109316 177 ------GIWYDEYPTSPKKHVLNGFIFSLAGLYDYY------TYTNSDKAKKLFLQGIDSLKEHLASFDAGFNSYYSwse 244 Campylobacter h...
EDK32457     291 dg--tdNVFFQEYITTPKSYTLNGFIFTIIGIYDLSqt---kDSIYKGDAHKMFVNCNDTLLKVIHKYDLGCMTAYDaay 365
EDK33052     247 ddrlkdKVFFQQYVNSTSTYTLNGFIFTLIGLYDWSnvncpgNIYYSNIAREYWDKGLNSLKLIIPYYDIGEFTAYDlhh 326
EDO47868     397 ------YPWYEEYPTTPSLYVLNGFIYSLVGLHDLTla---aPKK--TEAKAFFDDGMKSLKALLLMFDAGSGTFYDlrh 465
O18756       494 ------HDWYEEYPTTPSSFVLNGFMYSLIGLYDLKet---aGEKLGKEARSLYERGMESLKAMLPLYDTGSGTIYDlrh 564 cattle
Q29RD8       462 ------FDWYEEYPTTPSSFVLNGFIYSLIGLYDVAet---aGNKLGREAGILFSQGLESLKAMLPLFDTGSGTVYDlrh 532 zebrafish
EDK33137     405 ltrpgTPPTVN-FDYYGIHLTLLDALNIITGENDFKYYRNLWTS 447
Q8RBZ5       244 -----QCGNLAsPFYHKLHIALLEVLYELFNTIEFKTVKEKWES 282 Caldanaerobacter subterraneus subsp. tengcongensis
O26430       352 --gsyRPAWLAsEGYHRLHVQLANSLWKATGDSYYRSIALRWNS 393 Methanothermobacter thermautotrophicus str. Delta H
Q58528       270 -----ALGHRCnKHYEHLHRLQMLWLYNKTGDEIYLKYYKKWRE 308 Methanocaldococcus jannaschii DSM 2661
WP_012109316 245 npyihGIASMVgNKYHDLHIDQLLWIYYVTNDMFFKNYAHKFLK 288 Campylobacter hominis
EDK32457     366 itkkdQYPNMN-IQYHASHIELVDAMYSITNNPIYKYYNLMWKS 408
EDK33052     327 vvkksKPSSSD--FYHSVHIEQMNVLYNITKDHYFKNIRDMWIS 368
EDO47868     466 v-smrAPPNLArWDYHTLHVSLLHFISGIDSDRVVKDTAVRWTG 508
O18756       565 f-mlgIAPNLArWDYHTTHINQLQLLSTIDESPIFKEFVKRWKS 607 cattle
Q29RD8       533 f-tlgVAPNLArWDYHTTHINQLQLLASIDGAPIFRDYVKRWKT 575 zebrafish
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