Conserved Protein Domain Family
rad25
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TIGR00603: rad25 
DNA repair helicase rad25
All proteins in this family for which functions are known are DNA-DNA helicases used for the initiation of nucleotide excision repair and transacription as part of the TFIIH complex.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]
Links
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Statistics
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PSSM-Id: 273168
Aligned: 7 rows
Threshold Bit Score: 1255.86
Created: 7-Oct-2014
Updated: 25-Oct-2021
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
AAB62732   65 DYSkRCILKQDNKSRPIWVCP-DGHIFLETFSAIYKQASDFLVAIAEPVCRPQNIHEYQLTPYSLYAAVSVGLETNDIIT 143 Dictyostelium disc...
Q00578    117 DFS-YLRLRPDHASRPLWISPsDGRIILESFSPLAEQAQDFLVTIAEPISRPSHIHEYKITAYSLYAAVSVGLETDDIIS 195 Saccharomyces cere...
CAB11506   75 DFSnLLGLKLDHTARPLWINPiDGRIILEAFSPLAEQAIDFLVTISEPVSRPAFIHEYRITAYSLYAAVSVGLKTEDIIA 154 fission yeast
P49135     60 DYRqQMPLKGDHTSRPLWVAP-DGHIFLEAFSPVYKYAQDFLVAIAEPVCRPTHVHEYKLTAYSLYAAVSVGLQTSDITE 138 house mouse
CAB06045   66 DYRsNMEMKKDHASRPLYLAP-DGHIFLESFSPVYKHARDFLIAISEPICRPKFIHEFRLTPYSLYAAVSVGLDTEDIIE 144 vase tunicate
CAA48386   70 DYRsQMQLRPDHGNRPLWVAP-NGHVFLESFSPVYKHAHDFLIAISEPVCRPEHIHEYKLTAYSLYAAVSVGLQTHDIVE 148 fruit fly
NP_568592  51 DFTk-LELKPDHGNRPLWACA-DGRIFLETFSPLYKQAYDFLIAIAEPVCRPESMHEYNLTPHSLYAAVSVGLETETIIS 128 thale cress

AAB62732  144 VLGRLSKLALPKEVEQFVRQCTQSYGKVKLVLQKNKYFVESAYPEVLEFLLKDSSIATARIKPTLEEsvvd--------- 214 Dictyostelium disc...
Q00578    196 VLDRLSKVPVAESIINFIKGATISYGKVKLVIKHNRYFVETTQADILQMLLNDSVIGPLRIDSDHQVq------------ 263 Saccharomyces cere...
CAB11506  155 VLDRLSKTPIPPSIVDFIRACTVSYGKVKLVLKKNRYFIESGDASVLRLLLRDPVIGPLRIDYSTQSskqk--------- 225 fission yeast
P49135    139 YLRKLSKTGVPDGIIQFIKLCTVSYGKVKLVLKHNRYFVESSHPDVIQHLLQDPVIRECRLRNAEGEateli-------t 211 house mouse
CAB06045  145 YLGRLSKTSIPPGIVEFIRLCTQSYGKVKLVLKHNKYYVESSHVDVIQTLLRDYVIASCRKAVTEEEngeattsg-glqv 223 vase tunicate
CAA48386  149 YLKRLSKTSIPEGILEFIRLCTLSYGKVKLVLKHNKYFIESPHPEVLQKLLKDPVIQKCRLIRSEGEdfiqgtldgkait 228 fruit fly
NP_568592 129 VLNKLSKTKLPKEMIEFIHASTANYGKVKLVLKKNRYFIESPFPEVLKRLLSDDVINRARFSsep--------------- 193 thale cress

AAB62732  215 pktG----FIINKEVVTGAQISGGLQANQSLDPVLKNDALSNLLEEEEEDTVnnsdqHFHSFEIDPQQVEEVKKRCIQ-- 288 Dictyostelium disc...
Q00578    264 --pPe--dVLQQQLQQTAGKPATNVNPNDVEAVFSAVIGGDNEREEEDDDID-----AVHSFEIANESVEVVKKRCQE-- 332 Saccharomyces cere...
CAB11506  226 sskPsnedNVEDKKDITNDSSKETAEKSSSDELFSAVVG----LQEEEDDED-----AVHLFEIKHSSVETIKKRCAE-- 294 fission yeast
P49135    212 etfTsksaISKTAAEGSGGPSTSQGVDAQATSDIPKDLFDFYEQMDKDEEEEee--tQTVSFEVKQEMIEELQKRCIC-- 287 house mouse
CAB06045  224 stlVskqgLQVNKPS--NNAGEGQTAEDQNESAVPKDIYDFYEQIDKDDENAte-etQVVSFEVNQEMVETLQKRCIE-- 298 vase tunicate
CAA48386  229 qfgTklppGATDKPTADPAAAAGAVVAADGTTAVPEDITDFYEKIDKEEEDEdeanlKTVSFEVAQEKIEVIQKRCIE-- 306 fruit fly
NP_568592 194 -yyG--------GDGFSVGRTCGELEAGPGE---LLNEAEFAAAAee---------kETHSFEIDPAQVENVKQRCLPna 252 thale cress

AAB62732  289 LDYPVLEEYDFRNDTVNPNLNIDLKPTTMIRPYQEKSLsKMFGNGRARSGIIVLPCGAGKSLSGITAACTVKKSILVLCT 368 Dictyostelium disc...
Q00578    333 IDYPVLEEYDFRNDHRNPDLDIDLKPSTQIRPYQEKSLsKMFGNGRARSGIIVLPCGAGKTLVGITAACTIKKSVIVLCT 412 Saccharomyces cere...
CAB11506  295 IDYPLLEEYDFRNDNINPDLPIDLKPSTQIRPYQEKSLsKMFGNGRARSGIIVLPCGAGKTLVGITAACTIKKSVIVLCT 374 fission yeast
P49135    288 LEYPLLAEYDFRNDTLNPDINIDLKPTAVLRPYQEKSLrKMFGNGRARSGVIVLPCGAGKSLVGVTAACTVRKRCLVLGN 367 house mouse
CAB06045  299 LEYPLLAEYDFRNDTINKDLKIDLKPTTVLRPYQEKSLrKMFGNGRARSGVIVLPCGAGKTLVGVTAACTVRKRCMVLCT 378 vase tunicate
CAA48386  307 IEHPLLAEYDFRNDTNNPDINIDLKPAAVLRPYQEKSLrKMFGNGRARSGVIVLPCGAGKSLVGVTACCTVRKRALVLCN 386 fruit fly
NP_568592 253 LNYPMLEEYDFRNDNVNPDLDMELKPHAQPRPYQEKSLsKMFGNGRARSGIIVLPCGAGKSLVGVSAAARIKKSCLCLAT 332 thale cress

AAB62732  369 SAVSVEQWKYQFKLWSNIEERQISKFTSDNKEKISNVAGVTITTYTMVAFGGRRSAESLKIMNEITNREWGLVLLDEVHV 448 Dictyostelium disc...
Q00578    413 SSVSVMQWRQQFLQWCTLQPENCAVFTSDNKEMFQTESGLVVSTYSMVANTRNRSHDSQKVMDFLTGREWGFIILDEVHV 492 Saccharomyces cere...
CAB11506  375 SSVSVMQWRQQFLQWSNIKPDHIAVFTADHKERFHSEAGVVVSTYSMVANTRNRSYDSQKMMDFLTGREWGFILLDEVHV 454 fission yeast
P49135    368 SAVSVEQWKAQFKMWSTIDDSQICRFTSDAKDKPIG-CSVAISTYSMLGHTTKRSWEAERVMEWLKTQEWGLMILDEVHT 446 house mouse
CAB06045  379 SGVAVEQWRSQFKMWSTADDSMICRFTSDAKDRPHG-CSIAISTYSMMGHSMKRSYESEKVMEWIRSQEWGLIVLDEVHT 457 vase tunicate
CAA48386  387 SGVSVEQWKQQFKMWSTADDSMICRFTSEAKDKPMG-CGILVTTYSMITHTQKRSWEAEQTMRWLQEQEWGIMVLDEVHT 465 fruit fly
NP_568592 333 NAVSVDQWAFQFKLWSTIRDDQICRFTSDSKERFRGNAGVVVTTYNMVAFGGKRSEESEKIIEEMRNREWGLLLMDEVHV 412 thale cress

AAB62732  449 VPAAMFRKVLTVTKAHCKLGLTATLLREDEKIQDLNFLIGPKLYEANWLDLQKAGFLANVSCSEVWCPMTAEFYKEYL-I 527 Dictyostelium disc...
Q00578    493 VPAAMFRRVVSTIAAHAKLGLTATLVREDDKIGDLNFLIGPKLYEANWMELSQKGHIANVQCAEVWCPMTAEFYQEYL-R 571 Saccharomyces cere...
CAB11506  455 VPAAMFRRVVTTIAAHTKLGLTATLVREDDKIDDLNFLIGPKMYEANWMDLAQKGHIAKVQCAEVWCAMTTEFYNEYL-R 533 fission yeast
P49135    447 IPARMFRRVLTIVQAHCKLGLTATLVREDDKIVDLNFLIGPKLYEANWMELQNNGYIAKVQCAEVWCPMSPEFYREYV-A 525 house mouse
CAB06045  458 IPAKQFRRVLTVVQSHCKLGLTATLVREDDKISDLNFLIGPKLYEANWMELQNGGFIARVQCAEVWCPMTPEFYREYL-S 536 vase tunicate
CAA48386  466 IPAKMFRRVLTIVQSHCKLGLTATLLREDDKIADLNFLIGPKLYEANWLELQKKGYIARVQCAEVWCPMSPEFYREYL-T 544 fruit fly
NP_568592 413 VPAHMFRKVISITKSHCKLGLTATLVREDERITDLNFLIGPKLYEANWLDLVKGGFIANVQCAEVWCPMTKEFFAEYLkK 492 thale cress

AAB62732  528 NDSQgKKKLLYTMNPNKFRACEYLIRFHE-QRGDKIIVFSDNVYALQKYAKGLGRYFIYGPTSGHERMSILSKFQHDPTV 606 Dictyostelium disc...
Q00578    572 ETAR-KRMLLYIMNPTKFQACQFLIQYHE-RRGDKIIVFSDNVYALQEYALKMGKPFIYGSTPQQERMNILQNFQYNDQI 649 Saccharomyces cere...
CAB11506  534 ENSR-KRMLLYIMNPKKFQACQFLIDYHE-KRGDKIIVFSDNVYALRAYAIKLGKYFIYGGTPQQERMRILENFQYNELV 611 fission yeast
P49135    526 IKTK-KRILLYTMNPNKFRACQFLIKFHE-RRNDKIIVFADNVFALKEYAIRLNKPYIYGPTSQGERMQILQNFKHNPKI 603 house mouse
CAB06045  537 IRSR-KRLLLYVMNPNKFRACQFLVRFHE-RRNDKIVVFSDNVFALKEYAVRMGKPYIYGPTTQGERLQILQNFIHNPKV 614 vase tunicate
CAA48386  545 TKTS-KKMLLYVMNPSKFRSCQFLIKYHE-QRGDKTIVFSDNVFALKHYAIKMNKPFIYGPTSQNERIQILQNFKFNSKV 622 fruit fly
NP_568592 493 ENSK-KKQALYVMNPNKFRACEFLIRFHEqQRGDKIIVFADNLFALTEYAMKLRKPMIYGATSHIERTKILEAFKTSKDV 571 thale cress

AAB62732  607 RTIFISKVGDTSIDIPEATVIIQVSSHYGSRRQEAQRLGRILRPKPKSDG-------LYNAFFYSLVSKDTQEMYYSTKR 679 Dictyostelium disc...
Q00578    650 NTIFLSKVGDTSIDLPEATCLIQISSHYGSRRQEAQRLGRILRAKRRNDE-------GFNAFFYSLVSKDTQEMYYSTKR 722 Saccharomyces cere...
CAB11506  612 NTIFLSKVGDTSIDLPEATCLIQISSHYGSRRQEAQRLGRILRAKRRNDE-------GFNAFFYSLVSKDTQEMYYSSKR 684 fission yeast
P49135    604 NTIFISKVGDTSFDLPEANVLIQISSHGGSRRQEAQRLGRVLRAKKGMVAe------EYNAFFYSLVSQDTQEMAYSTKR 677 house mouse
CAB06045  615 NTIFISKVGDNSIDLPAANVLIQVSSHGGSRRQEAQRLGRILRAKKGSLAe------EYNAFFYSLVSQDTVEVAYSTKR 688 vase tunicate
CAA48386  623 NTIFVSKVADTSFDLPEANVLIQISSHGGSRRQEAQRLGRILRAKKGAIAe------EYNAFFYTLVSQDTMEMSYSRKR 696 fruit fly
NP_568592 572 NTVFLSKVGDNSIDIPEANVIIQISSHAGSRRQEAQRLGRILRAKGKLEDrmaggkeEYNAFFYSLVSTDTQEMYYSTKR 651 thale cress

AAB62732  680 QQFLIDQGYSFKVISELPGIDQEVNLKYSSKQDQLDLLAQVLGEGEDSGKNEILEEDFDDItrG-AKKSKSSAPTVSRTT 758 Dictyostelium disc...
Q00578    723 QAFLVDQGYAFKVITHLHGMENIPNLAYASPRERRELLQEVLLKNEEAAGIEVGDDADNSV--GrGSNGHKRFKSKAVRG 800 Saccharomyces cere...
CAB11506  685 QAFLIDQGYAFKVITNLKGMENLPNLAYASKAERLELLQEVLLQNEEAADLDDGEDT--Sf----GSRSLSRAPAKAKRS 758 fission yeast
P49135    678 QRFLVDQGYSFKVITKLAGMEEE-ELAFSTKEEQQQLLQKVLAATDLDAEEEVVAGEFGSR------------SGQASRR 744 house mouse
CAB06045  689 QRFLVDQGYSFKAITHLTGIDEEEQLAFTTKDEQHALLQKVLAASDLDAEEEMVPGEFGVGd----------kGKGGFRR 758 vase tunicate
CAA48386  697 QRFLVNQGYSYKVITHLKGMDTDSDLMYGTQEEQGQLLQLVLSASDLDCEDEKLPGEPGYRpsG---------SGGIVRR 767 fruit fly
NP_568592 652 QQFLIDQGYSFKVITSLPPPDAGSSLSYHSQEEQLSLLGKVMNAGDDLVGLEQLEEDTDGMalQkARRSMGSMSVMSGSK 731 thale cress

AAB62732  759 GGSTRALSGGNDMNYMEYQAPAIYKSIp---TQHALFKQ 794 Dictyostelium discoideum
Q00578    801 EGSLSGLAGGEDMAYMEYSTNKNKELK----EHHPLIRK 835 Saccharomyces cerevisiae S288c
CAB11506  759 SGSLSTLAGADNMAYVEYNKSANKQLKkdskEHHALFRK 797 fission yeast
P49135    745 CGTMSSLSGADDTVYMEYHSSRSKASSk---HVHPLFKR 780 house mouse
CAB06045  759 AGAMSSMSGADDSVYMEYRKTKQRKG------VHDLFKQ 791 vase tunicate
CAA48386  768 VGGLSSMSGGDDAIYYEHRKKNIGS-------VHPLFKK 799 fruit fly
NP_568592 732 GMVYMEYNSGRHKSGQQFKKP---KDPt---KRHNLFKK 764 thale cress
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