3EYC,4RUN


Conserved Protein Domain Family
lipocalin_1_3_4_13-like

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cd19414: lipocalin_1_3_4_13-like 
lipocalin-1, -3, -4, -13 and similar proteins
Lipocalin-1 (LCN1, also known as tear lipocalin, von ebner's gland protein, or tear specific prealbumin), the main lipid carrier in human tears, is critical to functions involving lipids in protection of the ocular surface. Its large ligand pocket accommodates a range of ligands including alkyl alcohols, glycolipids, phospholipids, cholesterol, steroids, and siderophores. Lipocalin-3 (LCN3, also known as vomeronasal secretory protein 1) and lipocalin-4 (LCN4, also known as vomeronasal secretory protein 2) are involved in transport of lipophilic molecules, and are possibly pheromone-carriers. Lipocalin-13 (LCN13, also known as odorant binding protein 2A) may bind and transport small hydrophobic volatile molecules with a higher affinity for aldehydes and large fatty acids. Another member of this family is late lactation protein B (LLPB), a milk protein produced during the late phase of lactation, which may be involved in transporting a small ligand released during the hydrolysis of milk fat. This group belongs to the lipocalin/cytosolic fatty-acid binding protein family which have a large beta-barrel ligand-binding cavity. Lipocalins are mainly low molecular weight extracellular proteins that bind principally small hydrophobic ligands, and form covalent or non-covalent complexes with soluble macromolecules, as well as membrane bound-receptors. They participate in processes such as ligand transport, modulation of cell growth and metabolism, regulation of immune response, smell reception, tissue development and animal behavior. Cytosolic fatty-acid binding proteins, also bind hydrophobic ligands in a non-covalent, reversible manner, and have been implicated in intracellular uptake, transport and storage of hydrophobic ligands, regulation of lipid metabolism and sequestration of excess toxic fatty acids, as well as in signaling, gene expression, inflammation, cell growth and proliferation, and cancer development.
Statistics
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PSSM-Id: 381189
Aligned: 19 rows
Threshold Bit Score: 185.993
Created: 6-Feb-2006
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
ligand bindingcitrate-binding
Conserved site includes 24 residues -Click on image for an interactive view with Cn3D
Feature 1:ligand binding cavity [chemical binding site]
Evidence:
  • Comment:ligands are bound within the beta-barrel in a central internal water-filled cavity lined with polar and hydrophobic amino acids
  • Comment:based on human tear lipocalin and on other lipocalin/cytosolic fatty-acid binding protein family members with structure
  • Structure:3EYC; Homo sapiens tear lipocalin with bound 1,4-butanediol, contacts 4A

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1         #   #          #           # #       # # #          # # #        # #    ## #
3EYC_A      5 EIQDVSGTWYLKAMTVDREFPem-nLESVTPMTLTTLEgGNLEAKVTMLiSGRCQEVKAVLEKTDEPGKYTAd-gGKHVA 82  human
4RUN_A      6 EEEDITGTWYVKAMVVDKDFPedrrPRKVSPVKVTALGgGNLEATFTFMrEDRCIQKKILMRKTEEPGKFSAy-gGRKLI 84  human
CAB71324   21 EEEDITGTWYVKAMVVDKDFPedrrPRKVSPVKVTALGgGKLEATFTFMrEDRCIQKKILMRKTEEPGKYSAc--LSAVE 98  human
125950     25 EFKPSEGTYYVQVIAVDKEFPedeiPRDISPLTITYLNnGKMEAKFTVKkDNNCEEINLTLEKIDEPRKITTtrhLHHIC 104 tammar wallaby
AAL85634   24 SEEQFEGTYFVKAIVTDSEFFeknkPKALSPLTVTHLSnGDLEAKFTTNmNGICEEIKMKFEKTDKPGIFSTn-dGSRQV 102 tammar wallaby
Q8K1H9     26 DLVDYSGIWYAKAMVHNGTLPshkiPSIVFPVRIIALEeGDLETTVVFWnNGHCREFKFVMKKTEEPGKYTAf-hNTKVI 104 house mouse
EHB05606   28 EEPDITGTRYMKAIVTNGNLTh--gPRQAFPVTVMAWEgVNFETRITFMwRGGCYKDRLHLQKTTEPGKYTLw--NHTHI 103 naked mole-rat
NP_775171  26 DQEDFSGKWYTKATVCDRNHTdgkrPMKVFPMTVTALEgGDLEVRITFRgKGHCHLRRITMHKTDEPGKYTTf-kGKKTF 104 Norway rat
AAR11375   26 DLVDYSGIWYAKAMVHNGTLPshkiPSIVFPVRIIALEeGDLETTVVFWnNGHCREFKFVMKKTEEPGKYTAf-hNTKVI 104 house mouse
Q8SQ30     24 SEEQFEGTYFVKAIVTDSEFFeknkPKALSPLTVTHLSnGDLEAKFTTNmNGICEEIKMKFEKTDKPGIFSTn-dGSRQV 102 tammar wallaby
Feature 1      #        # # #          # # # #                                       
3EYC_A     83 YIIRSHvkDHYIFYSEGElh--gkPVRGVKLVGRDPKNNLEALEDFEKAAGARGLsteSILIPRQS-ETCS 150 human
4RUN_A     85 YLQELPgtDDYVFYSKDQrr--ggLRYMGNLVGRNPNTNLEALEEFKKLVQHKGLseeDIFMPLQT-GSCV 152 human
CAB71324   99 MDQITPa-LWEALAIDTLrklrigTRRPRIRWGQEAHVPAGAAQEGPLHLLLQRP---APWGPAPHgKACG 165 human
125950    105 DTVRTSeeKYWILSCVREfq--gtQIREAELVGPNTDENPKALEDFYRFINRERFverRIITPRQT-EACT 172 tammar wallaby
AAL85634  103 LIEKTSvrDHWILFCEGElh--gmQVRIAKLLGPHTDENPKAFQEFKKFVSLKRFneeKINIPRQT-ETCI 170 tammar wallaby
Q8K1H9    105 HVEKTSvnEHYIFYCEGRhng-tsSFGMGKLMGRDSGENPEAMEEFKNFIKRMNLrleNMFVPEIG-DKCV 173 house mouse
EHB05606  104 HTEELAvkDHSACYAEHQlpl-geTMHVGYLMGRTPEENPEALEEFRKFVQRKRLpqeKIVIPEQR-ESCV 172 naked mole-rat
NP_775171 105 YTKEIPvkDHYIFYIKGQrh--gkSYLKGKLVGRDSKDNPEAMEEFKKFVKSKGFreeNITVPELL-DECV 172 Norway rat
AAR11375  105 HVEKTSvnEHYIFYCEGRhng-tsSFGMGKLMGRDSGENPEAMEEFKNFIKRMNLrleNMFVPEIG-DKCV 173 house mouse
Q8SQ30    103 LIEKTSvrDHWILFCEGElh--gmQVRIAKLLGPHTDENPKAFQEFKKFVSLKRFneeKINIPRQT-ETCI 170 tammar wallaby

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