1INP,1JP4


Conserved Protein Domain Family
IPPase
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cd01640: IPPase 
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IPPase; Inositol polyphosphate-1-phosphatase, a member of the Mg++ dependent family of inositol monophosphatase-like domains, hydrolyzes the 1' position phosphate from inositol 1,3,4-trisphosphate and inositol 1,4-bisphosphate. Members in this group may also exhibit 3'-phosphoadenosine 5'-phosphate phosphatase activity, and they all appear to be inhibited by lithium. IPPase is one of the proposed targets of Li+ therapy in manic-depressive illness.
Links
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Statistics
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PSSM-Id: 238818
Aligned: 17 rows
Threshold Bit Score: 283.83
Created: 6-Jul-2004
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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active site
Conserved site includes 22 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Structure:1JP4: PAP complexed with AMP, Pi, and magnesium ions
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                       #                        ##   
1INP        4 ILQELLRVSEKAANIARACRQqetlfqllieekkegeknkkfavdFKTLADVLVQEVIKENMENKFpglgkKIFGEESNe 83  cow
CAF96542    4 LLRLLLQVAEKAANVARVCRQeaplfqllvqektgddknkkfvqdFKTLADVVIQEMIRHDVGAQFpemlgFIHGEESNk 83  Tetraodon nigrovir...
XP_318273  28 LLREVLKASEKAANIARVCRQnpilfsllvqekskdesntrfahdFKTLADCLIQEMIKHDIGKQFpelrdNIRGEENAk 107 Anopheles gambiae ...
1JP4_A     11 LVASAYSIAQKAGTIVRCVIAegdlgiv----------qktsatdLQTKADRMVQMSICSSLSRKFpk--lTIIGEEDLp 78  Norway rat
NP_060283  66 MLAVSVLAAVRGGDEVRRVREsnvlheksk------gktregaedKMTSGDVLSNRKMFYLLKAAFps--vQINTEEHVd 137 human
AAH68839   50 DLRELLAVSVRAAELGGVEVKkvresnslnek--akgktregedeKMTSGDVLSNKKMYHLIKNAFpa--vLVNTEEQVd 125 African clawed frog
AAF48246   59 KMLIAAIQAAQRGGLEVLDVArsrqlkersk-----gktdegvndPFTDADGRSHCVMKQGLQRIFpr--vQIFSEEDKe 131 fruit fly
AAO53213   10 LTSACIKLAQESGDIIRDVFKsgslgie-----------mksvddPMTKADLLSQQHIIGSLRTIWsd--iKIVGEEQCe 76  Dictyostelium disc...
XP_321739  52 KLLIGSIQAAQHGGFEVVAVSksrdlheqsk-----gktkegannPVTDADYRSNCVMKNGLLRIFpk--lKVISEEDDr 124 Anopheles gambiae ...
CAF91329   46 DLRDLLAVSVEAAVLGGKEVKrireedglkek--skgktkegateLLTMGDLQSHRKMFNLLKNTFpd--iTVYSEEYDn 121 Tetraodon nigrovir...

Feature 1                                                                                     
1INP       84 ltndlgekiimrlgpteeetvalls-------------------------------------------kvlngnklasea 120 cow
CAF96542   84 fenghalslhdcafllahvlvpahagqtpefpagnsfsvpsweaewsltvppgesvtvtvcstegetaallasvldnnht 163 Tetraodon nigrovir...
XP_318273 108 ftntagesiivsvtddpgnttkale-------------------------------------------kilngdkvsaaa 144 Anopheles gambiae ...
1JP4_A     79 pgevdqel------------------------------------------------------------------------ 86  Norway rat
NP_060283 138 aadqevil------------------------------------------------------------------------ 145 human
AAH68839  126 pdeedavs------------------------------------------------------------------------ 133 African clawed frog
AAF48246  132 hckqah-------------------------------------------------------------------------- 137 fruit fly
AAO53213   77 iptidkkp------------------------------------------------------------------------ 84  Dictyostelium disc...
XP_321739 125 qeqcadv------------------------------------------------------------------------- 131 Anopheles gambiae ...
CAF91329  122 tadkvsw------------------------------------------------------------------------- 128 Tetraodon nigrovir...

Feature 1                                         ###### #                                    
1INP      121 lakvvhqdvffsdpALDSvei----niPQDILGIWVDPIDSTYQYIKGsaditpnqgifpsgLQCVTVLIGVYDiqtgVP 196 cow
CAF96542  164 aasllaraihrdpvTIDAhadapavplNPSDLGIWIDPIDATSQYIEGreevleeghlcpsgLHCALVLIGVYLrssgEP 243 Tetraodon nigrovir...
XP_318273 145 lvdevyreveidfeSLELptdsipldnDWSQLGIWIDPIDGTAEYIKGeekltkysnivssgLKCCTVLIGVYEtckgTP 224 Anopheles gambiae ...
1JP4_A     87 ------iedgqseeILKQpcpsqysaiKEEDLVVWVDPVDGTKEYTEGl-------------LDNVTVLIGIAYe--gKA 145 Norway rat
NP_060283 146 ------wdhkipedILEEvttp--kevPAESVTVWIDPLDATQEYTEDl-------------RKYVTTMVCVAVn--gKP 202 human
AAH68839  134 ------wdhdipdeIKDKikts--kpvSSESITIWIDPLDATHEYAENl-------------VKYVTTMVCVAVn--gKP 190 African clawed frog
AAF48246  138 -------gydldptVLHEtaqipdvtvNAQDVTVWVDPLDATKEFTEEl-------------YEYVTTMVCVAVa--gRP 195 fruit fly
AAO53213   85 -----pidllandkDCIEkcpeefkqlPIDDLIIFIDPLDATREFTLGr-------------VGCVMTLIGISFk--gKP 144 Dictyostelium disc...
XP_321739 132 ------qlfdldptVLPEsvtvpdervSIDEVDVWIDPLDATQEYTERl-------------HEYVTTMVCVAVk--gVP 190 Anopheles gambiae ...
CAF91329  129 -------trdvpadILEKidrg--kmvPVDGVTVWIDPLDATQEYTENl-------------LKYVTTMVCVAVq--gKP 184 Tetraodon nigrovir...

Feature 1                                                                                  #  
1INP      197 LMGVINQPFVSqdlht-----rrwkGQCYWGLSylgTN-IHSllppvstrsnseaqsqgtqnpssegscrfsVVISTSek 270 cow
CAF96542  244 VMGVINQPFYSkdpas-----gswsGRHFWGVSyggVN-ACSesrpkdv-----------------pgagpsAVLSSSek 300 Tetraodon nigrovir...
XP_318273 225 ILGVINQPFAEkisnqee-freeyrSKIFWGLSv--GDlKFNniasqg-------------------tdariAILSPSeq 282 Anopheles gambiae ...
1JP4_A    146 IAGIINQPYYNyqagp-----davlGRTIWGVL---GLgAFGfqlke--------------------apagkHIITTTrs 197 Norway rat
NP_060283 203 MLGVIHKPFSEyt-----------aWAMVDGGS---NVkARSsyne----------------------ktprIVVSRShs 246 human
AAH68839  191 VIGVIHKPFTGyt-----------aWAMVDEGA---NIkKRSsyne----------------------ktptFIVSRShs 234 African clawed frog
AAF48246  196 IIGVIHSPFNGqtaw------awvgNSMSEYLSn-lHP-QHSpnnq-----------------------apiITVSRSht 244 fruit fly
AAO53213  145 IAGIIYQPFVDcngdgtt-dqskwvGRTIWAIV---GGgIPVkgikdrr----------------apedvgkVILTTTas 204 Dictyostelium disc...
XP_321739 191 TIGIIHNPFSMkttw------awrgKALSESLV---NL-KHDadvk-----------------------hptIIVSRSha 237 Anopheles gambiae ...
CAF91329  185 VIGVIHQPFTGftawafvgqgsnmrSRSAYSVNp-pTV-IVSrshsgkvks-------------fiqeafgnTTIIPAgg 249 Tetraodon nigrovir...

Feature 1                         ####  #                    # #   ##  ##                     
1INP      271 etikga---lshvcgeRIFRAAGAGYKSLCVILGl---------ADIYIFSEdTTFKWDSCAAHAILRAMGGGMVDLkec 338 cow
CAF96542  301 qvvkea--laalcgpdKLMYASGAGFKILCVIQGl---------ADVYVLSEgSTFKWDSCAPHALLRALGGGVADLaqs 369 Tetraodon nigrovir...
XP_318273 283 skyvef---irnqlkyDVVYSSGAGYKILKIATGe---------AELFLLSKgTTYKWDTCAPQAILRSMNGDLFDLqdt 350 Anopheles gambiae ...
1JP4_A    198 hsnklvtdciaamnpdNVLRVGGAGNKIIQLIEGk---------ASAYVFASpGCKKWDTCAPEVILHAVGGKLTDIhg- 267 Norway rat
NP_060283 247 gmvkqva-lqtfgnqtTIIPAGGAGYKVLALLDVpdks---qekADLYIHVT-YIKKWDICAGNAILKALGGHMTTLsg- 320 human
AAH68839  235 gevkevt-rqtfgnktEIISAGGAGYKVLSLLDVtade---qekADVYIHVT-YIKKWDICAGNAILNALGGHMTTLkg- 308 African clawed frog
AAF48246  245 agakdla-rgifgenvSLLTAAGAGYKVLQVVANn---------ATAYLHTS-KIKKWDICAGDAILHALGGTMTTLn-- 311 fruit fly
AAO53213  205 hfndkvqqavdaikpdKLLRAGGAGYKSLLVIENq---------ADVYVFPTvGSKLWDICGPHAILLAVGGKLTDPqg- 274 Dictyostelium disc...
XP_321739 238 gavkeqs-kqifgenaQVITAGGAGFKVLQVIQNn---------ATAYLHTT-HIKKWDICAGDAILGAIGGRMSDLhn- 305 Anopheles gambiae ...
CAF91329  250 --------------avEVGVFVRVRYKVLSLLEMpshdekpidqADVYVHVT-LIKKWDICAGAALLSALGGQMTTLkg- 313 Tetraodon nigrovir...

Feature 1                                                       
1INP      339 lernpdtgldlpQLVYhvgnegaagvdQWANKGGLIAYRsekQLETFLSR 388 cow
CAF96542  370 lq------egqaELTYhqpceerrgaeRWANHGGLLAYRdqaRLHAVVRT 413 Tetraodon nigroviridis
XP_318273 351 li-----nksvkKISYhd-------hkVTRNIGGLIAYQnidKLREFLKL 388 Anopheles gambiae str. PEST
1JP4_A    268 -----------nPLQYdk-------evKHMNSAGVLAALr--NYEYYASR 297 Norway rat
NP_060283 321 -----------eEISYt---------gSDGIEGGLLASIr-mNHQALVRK 349 human
AAH68839  309 -----------eEISYt---------gSEQNEGGLLASIg-mDHSALVGK 337 African clawed frog
AAF48246  312 -----------dQLINygp------eeSPVNTEGLLATLe--QHDEYMDK 342 fruit fly
AAO53213  275 -----------nDIIYstd------peKIENKNGIIITIs--NHQKYIDL 305 Dictyostelium discoideum
XP_321739 306 -----------eNIAYhr-------dtPALNPNGLLAAAlssTHEAYIKR 337 Anopheles gambiae str. PEST
CAF91329  314 -----------eDIDFs---------gTPVNKGGLVASVg-vNHKVLVDR 342 Tetraodon nigroviridis

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