Conserved Protein Domain Family
DUF4735

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pfam15882: DUF4735 
Domain of unknown function (DUF4735)
This family of proteins is functionally uncharacterized. This family of proteins is found in eukaryotes. Proteins in this family are typically between 288 and 410 amino acids in length. There are two completely conserved C residues that may be functionally important. In mammals this protein family is thyroid-specific.
Statistics
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PSSM-Id: 464922
Aligned: 30 rows
Threshold Bit Score: 216.06
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EKC32734      50 DGLFGLRMAQGQILAAV-EEC----HKRPVCSARYLSKIKDLESKVGETSDKALPYVKDSDPAYYERFYQTIAKA-WILP 123
EDV21740      82 pSLIGLRIAQGQFEVITnDRR----FFNMTLYYDALQMYHQISRLLLADATSEATYWSKKNQKYHSSSNTLVSQP-WKLS 156
EDV19272      61 ldAYNLLIAISAFRDITkEYF----LENSYLSSQDVKRISEMNVAVNILFQNS---LEKFSPEYRLVFSEEVSFAa---- 129
XP_002118253  53 DSTLSFHFTKGYLRTIL-EDAs---RNESLLSHNQLDRVTKLYDRFRGLIEDTAPTISQKHYQYK--FLIPLYVRnFKVP 126
EDV20652      73 DGYIGLLKAKEYLGATV-ENId---KGLSPLSTQQANQVKQIFENCSVLLIHIEAVLVNSSSSKQYDLFKMVHTP-HPIP 147
EDV19254      67 DGYFGFTGSKGFIRATI-KNYh---DGLSTLNTQQINRVQQIYQRIIAVSKRIEPILANNSMAYNT-IGKIVQGS-LPVP 140
XP_002118250  67 gAYYGLVRCGEYVKATL-DDYy---RGLSILNVQQLNRIKQIHKRIIDVSKKIQPILAKNSQSYRQ-LHKLTQTP-ITVP 140
PDM83717      37 DLVFGLRVIQGESDRLA-EQL-----ASRSPPETLVDILRRVSKEAAEAADSLGNLTRDDSPIQYDRLRRLLEQP-YPLW 109
CCD75790      52 DGIFGLIPLKGALESITdDSLyenyERVKIALLPLMRKLKTQIMRINVIIRKSVKFFKKARDSYYTKMGRLLALK-WNFP 130
EGI62344      11 DAAFGITLTEANLVAALl------hENVQYLEDKFFIALKEMVVLSDLTRKHLMKIIAPKNETKFLMLSTLNNPNqWIKP 84 
EKC32734     124 YQAM--LFD------KAELGSVKLGTNTs----------YDEDYGDACYARV-MGTFdknlpRCTVTPECW-DFMTSPDT 183
EDV21740     157 NLDRefKLI---------------PVQIrneriydhgihHGNDYGMACLNEL-MGQRna--mPCTISAECW-QSNILEDL 217
EDV19272     130 ------VARyingtkPSLPISGPTPANT-----------FPSNMSEICIATTlSGSIgs--aSCNVTEACW-NYISQPGT 189
XP_002118253 127 RKLRklNHTyvqqsqEHS---------------------VSRHYSNQCLWEI-VGSWpyyrrPCNLSDICV-KFISQLHS 183
EDV20652     148 NQLIslRLSnvhsgaLDKDSTAGV---------------KFANISDMCLMDI-IGTRkrhqpACTFSDICW-KGITNYHA 210
EDV19254     141 KRLVklNFTklynvsSDEILSPKS---------------GYMNISDWCIGNI-IGSKalhvaPCTISDTCW-TGITNYHG 203
XP_002118250 141 EGLVslNFTelhhvvLHDGSPESK---------------NWENISDSYLHMI-SGSGny--qVCTITNTSW-ADITNYHT 201
PDM83717     110 QRLSerKTD------HHLIWSARTMFSSn----------LTDEISNRCISEL-FSSSad--gDCRPSKECLeVMLNTKHL 170
CCD75790     131 GQNT-----------MYSYLSDPEPISS-----------AQNISSDECIIQL-LNTNnygtlDCHLSMECI-LKLMDFNS 186
EGI62344      85 ISWT--KVFsklrshPQL-LNYQEVVRSiwh------gtPTETESDQCLIEI-MRSSlk--eECEIPVACVaTLIKEDDT 152
EKC32734     184 SQYALTHQLLYFIVIEHVG-----------------CLKDVERNlkg----kkiRDVQSRMCEKIYKEA-EGLVKKt--- 238
EDV21740     218 QGHKLVRQIIYFMLAKDLK-----------------CHAQVTQRllhhskyhdvNDLLQAFCSYAYLEVkTLYEQYd--- 277
EDV19272     190 RMGLAVSQLYTDYFIRQLDy----------------CGFKLVKlagg---irrlMAVEESLCSRIYMDFkKILHNN---- 246
XP_002118253 184 NNYIITHQVLALSFGRQFH-----------------CQHQIAPlssa---fgsvGNLEAILCSRVHKEMySSLYKG---- 239
EDV20652     211 RNFDIIHQLFAIFVGQKLN-----------------CTNKMNVlaqk---lggiENVKAALCSRIYRQMyTNLNNA---- 266
EDV19254     204 GYYGITHQLITILNGQRLN-----------------CTEKMNKlakn---lggiQKVKEVLCTQIYYQMqKELKKG---- 259
XP_002118250 202 DGYIITHQMLNILTGQQFN-----------------CTEKMDKlakd---lggiKKVTEVLCTQIYNEMqQELKKS---- 257
PDM83717     171 ANYALSRQLIYFTVATRQAsatppttflpyttfqklCRKAMLSYysmn--qtalTVHLTEFCSNVIHEMdLFLSRApkdl 248
CCD75790     187 RGYELAHQVLYILISHQVN-----------------CTDSLDGmlsnl--stsvGSLQNKLCSILYRDFvNLFLSS---- 243
EGI62344     153 TGYPLTHRLLIVQVAKVLG-----------------CEEIIDKtt-------slSSLVSTYCTRIFQDL-INLEAW---- 203
EKC32734     239 -NVKSINRDLFLEQTVLCG-PLGYESFMREDWMAMTLRWLdTHYGCFrm---tlDDLEqltdemvhdvykgmnvsketie 313
EDV21740     278 -LKMIQAQQIFLEEIVFCA-ASGFSDFYNYNFMKEVFQYQ-SFSGCF--------------------------------- 321
EDV19272     247 -ISDINKAELLLQQIIICGgMFGYVEFVSIYPLHQVFKYQ-ARSGCF--------------------------------- 291
XP_002118253 240 -LTNLKLQDLFTEQVDVCGsLEFFEDFINETYVDMVLEWQ-TTQGCYmqyngty-------------------------- 291
EDV20652     267 -LNKMQSWELFLAQIYICGgPAGFQKFVDAQFLSAILHWQ-SNTGCL--------------------------------- 311
EDV19254     260 -LKNIQMQDLFLEQIFVCGgWIGYQQFLKAQYLSMMLKWQ-TKAGCFipyygpfis------------------------ 313
XP_002118250 258 -LTFVPLQDLFLEQMYTCGaWGGYREFLNMEYLSMFLNWQ-TTAGCIaayygpfvs------------------------ 311
PDM83717     249 eSLTPLQKDLLMQHVFVCG-QHGFVDVIQPRVLWMLLGQQ-SEAGCF-------PLPAndap------------------ 301
CCD75790     244 -ETTPRNRDILLEEMFVCG-SIGYENFIQFSILSRVLSWQ-QPSGCFissgstdGKSKhknt------------------ 302
EGI62344     204 -NFPNVTRDLMLEQVVLCG-MEGYYEFVDKHYEDIILSWP-HWSGCF--------------------------------- 247
EKC32734     314 kakqlaeqeskesyeeqqekELKAETNSSPTMRKLMREKGM---------------------KD-D------CLAHTSGL 365
EDV21740     322 ---------------------------SMSKSRRKIRN------------------------IDhNekqdayCPKLKGTI 350
EDV19272     292 ----------------------------KNSARNRRSQRIMhlpcmlclynsvqisssleliNSrAdlasdeCNLHVSTV 343
XP_002118253 292 --------------tsifpnESNGTKLAPYYSRSKRSDSTG---------------------TD-G------CHQHISST 329
EDV20652     312 ---------------------KSSHSIFSSLGSELLPQNTLvtssd-----------hpiggIDkA------CYSRRSAA 353
EDV19254     314 ------------lhpkfnknYTRDSSQYSSATDELRTNLIT---------------------PD-G------CYEHRTSV 353
XP_002118250 312 ------------lhpnmtkdYTEDDSRYLFASDQLLIDKTIt--------------------GD--------CDQHTTAI 351
PDM83717     302 ----------------------------peiGRRLLAVAQS---------------------RP-G------CSGHSTSV 325
CCD75790     303 -----------------kimF---------HERHPLVEHRH---------------------AD-G------CLSHMTSV 328
EGI62344     248 -----------------------GVIELSNEHQITRRSSSI---------------------TDfG------CDNHTTSL 277
EKC32734     366 GFGVYATYLN 375
EDV21740     351 FFLSSVGFIY 360
EDV19272     344 AFASLATSLR 353
XP_002118253 330 ATVLIVAHLR 339
EDV20652     354 ATSVLSMYLH 363
EDV19254     354 ALIDVSIYLY 363
XP_002118250 352 GMSLVAAFLH 361
PDM83717     326 AAGASMVYLN 335
CCD75790     329 AAAVMGLYFR 338
EGI62344     278 AAASLAVFIR 287
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