Conserved Protein Domain Family
bHLHzip_TFAP4
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cd11419: bHLHzip_TFAP4 
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in transcription factor AP-4 (TFAP4) and similar proteins
TFAP4, also termed activating enhancer-binding protein 4, or Class C basic helix-loop-helix protein 41 (bHLHc41), is a bHLHzip transcription factor that activates both viral and cellular genes involved in the regulation of cellular proliferation, stemness, and epithelial-mesenchymal transition by binding to the symmetrical DNA sequence 5'-CAGCTG-3'.
Links
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Statistics
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PSSM-Id: 381425
Aligned: 25 rows
Threshold Bit Score: 93.1453
Created: 9-Jun-2011
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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putative DNAputative dimer
Feature 1:putative DNA binding site [nucleic acid binding site]
Evidence:
  • Comment:The N-terminal basic region of bHLH mediates high-affinity DNA-binding to specific hexanucleotide sequences
  • Comment:Based on structure evidence that Mus musculus E47 (2QL2)-NeuroD1 complex binds DNA.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1            #   # ### #    #                   ##                     
Q01664        46 RRIRREIANSNERRRMQSINAGFQSLKTLIPHT-DGEKLSKAAILQQTAEYIFSLEQEKTRL 106 human
EGD79154      42 SSRRRLAANGNERKRMQFINAGFKTLRQLVPMCrTEERISKGMVLQYTTAYIQQLQHTLRAQ 103 Salpingoeca sp. ATCC50818
NP_476605     94 KRMRREIANSNERRRMQSINAGFQSLRSLLPRH-EGEKLSKAAILQQTFQYIVELENQKTQL 154 fruit fly
EFX89268      48 KRVRREIANSNERRRMQSINSGFQSLRTLLPQS-EGEKLSKAAILQQTTEYIYQLEQEKTRL 108 common water flea
CCD59338      37 KRVRREIANSNERRRMQSINAGFDSLRILLPSIsDGEKMSKATILQLTAKYINTLLMRVSLL 98  Schistosoma mansoni
ALJ33555       7 RKIKRAAANVNERRRMQNINCGFEALRAILNVE-NSSKLSKSAILRHAVEMLRNLMSENQQL 67  Clytia hemisphaerica
P34474       110 SRMRRQIANCNERRRMQSINAGFLALRALLPRK-EGEKLSKAAILQQTADMVHQLLGHKGED 170 Caenorhabditis elegans
OQR77635     233 KRIRREIANSNERRRMQSINAGFQSLRVLLPQR-DGEKMSKAAILQHTAEYIYQLEQEKTRL 293 Tropilaelaps mercedesae
XP_003386949  96 KKLRRQIANSNERRRMQSINSGFHTLRMLMPHL-QGEKLSKASVLQHAAEHIFRLNQDRDRL 156 Amphimedon queenslandica
XP_009010738  31 RKMRRQIANCNERKRMKQINTGFESLRTLLPNL-VDEKISKAAILQQATIYIASLTRERDQL 91  Helobdella robusta

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