Conserved Protein Domain Family
ELP6

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pfam09807: ELP6 
Elongation complex protein 6
ELP6 is a subunit of the RNA polymerase II elongator complex. The Elongator complex promotes RNA-polymerase II transcript elongation through histone acetylation in the nucleus and tRNA modification in the cytoplasm. ELP5 and ELP6 play a major role in the migration, invasion and tumorigenicity of melanoma cells, as integral subunits of Elongator
Statistics
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PSSM-Id: 462909
Aligned: 17 rows
Threshold Bit Score: 306.956
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_004078402   2 FTELNSILNTSPESFTP---GEFILLSD-RQSDASFLIHHFLSFYLKARCKVCFVALVQSFSHYHAVSQRLGVSLTQAKE 77 
Q0P424         2 FPELNSLLNASPDTFKP---GDFILLSD-RQADASFLIHHYLSFYLRAGCKVCFLGLVQSFSHYSAVGQRLGVSLTQARE 77  zebrafish
EKC35631       1 MEDVNNVLDIAKDDNLY---GEVITLAD-STADGTFLIHHFLSFFLGNNRPVCFVSLSQSFGHHKSVCQKLGVSLTQKIE 76 
XP_004348246   2 FEGLNAALSLSNTAPPTelqGSLVLCADtLEADGGFLLHHWLATHLKTGAAVVLVSFAHIQNHFALVARKLGINLAQLEA 81 
XP_006010935   2 FAELNAILNSSPEKCAQ---ENFVCVCD-SKTDGSFLIHHFLSFYIKAGCKVCFVALVQSFSHYSIIAQKLGTNLGAAKE 77 
XP_003762242   2 FPELNNLLNVSPEKPEQ---GTFTLLCN-NKTDGSFLVHHFLSFYLKANCKVCFVALLQSFSHYNIVGQKLGVNLIAARD 77 
ELV09690       2 FPELNNLLNTSPDRAEQ---GKLTLLCA-AETDGSFLVHHFLSFYLKANCKVCFVALIQSFSHYNIVGQKLGVSLTAARE 77 
XP_002813850   2 FVELNNLLNTTPDRAEQ---GKLTLLCD-AKTDGSFLVHHFLSFYLKANCKVCFVALIQSFSHYSIVGQKLGVSLTMARE 77 
Q28CX0         2 FPELNSLLGAGTDTVER---GKFTLLCD-SKTDGSFLVHHFLSYYLRAGCRVCFVALVQSFSHYSIVAQKLGVNLSSAKD 77  tropical clawed...
NP_001264419   2 LEELNELLDATPQRPDT---GKFTLLRD-SRTDGSFLVHHFLSFYLRAGCKVCFLALVQSFSHYNIVAQKLGVSLTAAKE 77 
XP_004078402  78 KGQLIFLEGLKESLSVFLPQE-ENAGHQAMSFL-RDPAAGLRSLYEFVQSSVVESsggg-----gasaEQWGPPVLLMDD 150
Q0P424        78 KGQLVFLEGLKDSIGAILKED-TSEGTQALSYL-RSPRAGLEGLFRFVESSLCQS-------------GDDGPPVLIIDD 142 zebrafish
EKC35631      77 SSHLNFFDGLKVFGNRFLDTQpEN--------VdISNTTSLQGFYKAIKTNYEDLq-----------dKNKAPPVVIVDS 137
XP_004348246  82 RGMFRFIGGLDV-PSTDAQSQpSSGDFH----LdLSNPAPLKELHQRIQDTLKAMeasrraanpagedATQTPVCIILDS 156
XP_006010935  78 RGQLVFLEGLKSSVDILFSEEpRSAQPHPFQFIsNTGED-LKSLYHCIQTSLSQTd-----------sSTWKFPVLIVDD 145
XP_003762242  78 RGQLVFLEGLKSTVEILFGSE---EQPNTLKFFrESDTD-LKSLFELVHKALTPSgdg--------daASWKFPVLLVDD 145
ELV09690      78 RGQLVFLEGLKSSVDVFFQAQ---EKTHPLHFLrEANAGNLQPLYEFVQEALKPVds---------gaAAWRCPVLLVDD 145
XP_002813850  78 RGQLVFLEGLKSAVDVVFQAQ---KEPQPLQFLrEANAGNLKPLFEFVREALKPVds---------geARWTYPVLLVDD 145
Q28CX0        78 EGQLVFLEGLRSYTDLLFGDNpEAEVTNPLCFLrAGSD--LKPLYSFVSAALAPSa-----------gQSWKCPVLILDD 144 tropical clawed...
NP_001264419  78 RGQLVFLEGLKSCLDLVFGEEePSGQPSPLQFIsGSVSN-LKDLFDFVRTSLAPTd-----------sDSWKGRVLLVDD 145
XP_004078402 151 VSVLLSL---GVRVGAVLDFSHY---------CRTTVCSQLQ--------------GNVVMLVRCDGEAEEDDADdegse 204
Q0P424       143 LSVLLSL---GVSAGAILDFTLY---------CRATVCSELQ--------------GNMVILVRCEEEDADDDEEgl--n 194 zebrafish
EKC35631     138 LNVLLNI---GYQVKEISAFVQYlchlisgpgCDAR--------------------GTLITFLSIGENGLDEEAS----- 189
XP_004348246 157 VDTLFHAtggAITPAALLGFIHS---------CRSFPLVAPA--------------PCLVVSVHADALFGGAK------- 206
XP_006010935 146 LSVLLSL---GVNVVNVLDFIHY---------CRATICSKLK--------------GTVVTLAHSDEDIGDEEME----- 194
XP_003762242 146 LSVLLSL---GVRAVAVLDFIQS---------CRATVCWQLK--------------GNVVALVHDSDKTEDEENA----- 194
ELV09690     146 LSVLLSL---GVGAVAVLDFVHY---------CRATVCSELKvpraagsqpgpqgpGHAQAYVH---------------- 197
XP_002813850 146 LSVLLSL---GMGAVAVLDFIHY---------CRATVCWELK--------------GNMVVLVHDSGDAEDEEND----- 194
Q28CX0       145 VSVLLSL---GVPPLQLLDFMHY---------CRATVCTQYQ--------------GNVVCLVHGAEESGDEEKE----- 193 tropical clawed...
NP_001264419 146 LSVLLSL---GAAPVDVLDFIHY---------CRMVVCSQLK--------------GNIVVLVHGSEDSEDEENK----- 194
XP_004078402 205 QLMRGLTHQSCLTLHVQGLPTGYCRDIHGQVEFCWKKRQs--DGQHAPKKVFQFKVHD 260
Q0P424       195 LLQRGLVHQCHLALHVEGLPTGYCRDIHGQMEVWWRQGE---NDAYNQRKIFQFKVHD 249 zebrafish
EKC35631     190 LLWRSVVHMSNMDVLVSGLESGYCKDVHGKIEVKRRN-----LLKKNSQKTMQFKVND 242
XP_004348246 207 ALFATLKHQAQVTLTVSGLPSGYSKDVHGQLYISRASGL---DERPAPQSKLHYKIQD 261
XP_006010935 195 LIAKLLSHQSSLMLKLEGLATGYCKDVHGEIKITWRGASh-iKPQKNITEVYQYKIQD 251
XP_003762242 195 LLMNALGHQSSLILRAEGLLTGFCKDVHGQLKILWRGLQq-pKAEQTRSLIYQYKIQD 251
ELV09690     198 -------HQSHLVLRAEGLATGFCKDVHGQLRILWRASQp--TAQRGRSLTFQYKIQD 246
XP_002813850 195 ILLNGLSHQSHLILRAEGLATGFCRDVHGQLRILWRRPSq-sTAQRDQSFTYQYKIQD 251
Q28CX0       194 LLRRSLSHQSQVILWAEGLSSGFCKEVHGQLKIFRGAVSsgkKRGQTQPEIYQYKIQD 251 tropical clawed frog
NP_001264419 195 LVVTSLCHHSNLILWVQGLATGFCKDVHGEIKIIKRLSLe--STEQDVIQIYQYKIQD 250
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