Conserved Protein Domain Family
EFh_CREC_RCN1
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cd16229: EFh_CREC_RCN1 
EF-hand, calcium binding motif, found in reticulocalbin-1 (RCN-1)
RCN-1 is an endoplasmic reticulum resident low-affinity Ca2+-binding protein with six EF-hand motifs and a carboxyl-terminal His-Asp-Glu-Leu (HDEL) tetrapeptide signal. It is expressed at the cell surface. RCN-1 acts as a potential negative regulator of B-RAF activation and can negatively modulate cardiomyocyte hypertrophy by inhibition of the mitogen-activated protein kinase signaling cascade. It also plays a key role in the development of doxorubicin-associated resistance.
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Statistics
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PSSM-Id: 320027
Aligned: 6 rows
Threshold Bit Score: 449.716
Created: 29-Apr-2015
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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Feature 1:EF-hand motif [structural motif]
Evidence:
  • None
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1        ##############################                                                  
Q15293        48 RPPEDNQSFQYDHEAFLGKEDSKTFDQLTPdeskeRLGKIVDRIDNDGDGFVTTEELKTWIKRVQkryifdNVAKVWKDY 127 human
XP_005991288  37 QLHEDNQSFQYDHEAFLGKEEAKTFDQLTPeeskeKLGKIVNRIDDDKDGFVTAEELKNWIKRVQkryiyeNVAKVWTDY 116 coelacanth
NP_001090366  39 QIHEENQSFQQDHEAFLGKDEAKTFDQLTAeestdRLGKIVDRIDSDSDGLVNTEELTAWIKRVQkryvyeNVARVWKDY 118 African clawed ...
AGD98724      37 QTHQDTESFQYDHEAFLGKEEATTFDQLTPeesqeRLGKIVDRIDDNKDQFVTTEELKAWIKRVQkryiyeNVAKVWRDY 116 elephant shark
O93434        39 ATNEDNNSFQYDHEVFLGKEESKTFDQLSPeeskdRLSKIVDRIDGDGNSYITTDELKAWIKRVQkryvyeNVVKVWADY 118 torafugu
XP_003222745  41 HLHDDSQDFQYDHEAFLGKEEAKTFDQLTPeeskeRLAKIVDRIDKDKDGFVTQPELKDWIKHTQhryiyeNVNKNWKDY 120 green anole

Feature 1                                                                                        
Q15293       128 DRDKDDKISWEEYKQATYGYYlgnpaefhdssdhhtfkkmlpRDERRFKAADLNGDLTATREEFTAFLHPEEfehmkeiV 207 human
XP_005991288 117 DLNKDNKISWEEYKQATYGYYlanpeefqdatdqfsfkkmlpRDERRFKTADLDGDMAATREEFTSFLHPEEfehmkdiV 196 coelacanth
NP_001090366 119 DVNKDNAISWEEYKQATYGYYlanpeefqdateqfsfkkmlpRDERRFKQADLNGDLAANREEFTAFLHPEEfehmkdiV 198 African clawed ...
AGD98724     117 DLNKDNKIAWDEYKQATYGYYlenpeefqdiadqlsfkkmlhRDERRFKSADIDGDLVATREEFTAFLHPEEfehmkeiV 196 elephant shark
O93434       119 DLNKDNKISWEEYKQATYGYYlsnpeefdettdqfsfkkmlpRDERRFKRADLDGDSAANREEFTSFLHPEEfehmkdiV 198 torafugu
XP_003222745 121 DKDSDGHITWTEFKNATYGHYegeefgdled--kdsyrrmlaRDERRFKAADKDGDLSATREEFTAFLHPEEfdymkdlV 198 green anole

Feature 1                                                                                        
Q15293       208 VLETLEDIDKNGDGFVDQDEYIADMFSHEengpepdwvlsEREQFNEFRDLNKDGKLDKDEIRHWILPQDydhaqaEARH 287 human
XP_005991288 197 VLETLEDIDKDGDGYVNEDEYIADMFAHEeggpepewvktEREQFADFRDINKDGKMDKEEIQHWILPQDydhaqaEARH 276 coelacanth
NP_001090366 199 ILETLEDIDKNEDGFVDQDEYIADMFSHEeggpepdwvatEREQFADFRDLNKDGKMDKEEIRHWILPQDydhaqaEARH 278 African clawed ...
AGD98724     197 VLETLEDIDKDGNGFIDEDEYIADMFAHVegvaepdwvqtEREQFSDFRDLNKDGKMDKAEIRHWILPQDydhaqaEARH 276 elephant shark
O93434       199 VLETLEDIDKNSDGHVDEDEYIADMFAHEdrgpepewvktEREQFSDFRDLNKDGKMDLDEIRHWIMPQDydhaqaEARH 278 torafugu
XP_003222745 199 VTETIEDIDKNGDGFVEVDEYLGDMYSPEtgepepswvksERQQFLDHRDLNKDGKMDREEIGHWILPPDydhaevESKH 278 green anole

Feature 1                                   
Q15293       288 LVYESDKNKDEKLTKEEILENWNMFVG 314 human
XP_005991288 277 LVYESDLDKDQKLTKEEILENWNMFVG 303 coelacanth
NP_001090366 279 LIYESDLDKDKLLTKEEILHNWNMFVG 305 African clawed frog
AGD98724     277 LVYESDKDKDQKLSKQEILDNWNMFVG 303 elephant shark
O93434       279 LVYESDKDKDQMLTKEEILDNWNMFVG 305 torafugu
XP_003222745 279 LLVHSDVDKDEKITKQEILDNWNMFVG 305 green anole

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