Conserved Protein Domain Family
RD3

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pfam14473: RD3 
RD3 protein
RD3 is a human protein that is found preferentially expressed in the retina. Mutations in RD3 causes Leber Congenital Amaurosis type 12.
Statistics
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PSSM-Id: 464183
Aligned: 29 rows
Threshold Bit Score: 109.655
Created: 25-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_006003386   6 WM--------KWVKSDSYKP-P----QNSD----SEAVTRTLMRELTWHMKERERLVQETENEQKLLHTGVDYIWLR--S 66 
1_pfamImport   1 WLlngdkvahSFDAPTESQS-AraddRMNIgygeNYLLFDLVIGEVEMAVVRFELEREQKAEDERKAERRPDYSWLVsgS 79 
XP_017208112  20 FA--------GWPHTNGCVA--------PG------GSGRMLLREMLWQLEQRALQFQEEEIQYCISRGILGYRHRP--A 75 
XP_002600040   6 WL--------PWTGSEQQFP-G----QKPD----SMVVADCLMTELEWQLREADRLAREREEEERRRQTKVDYSWLActS 68 
XP_002111930  11 FF--------KFNHNHQCHQsAh---RRQA----DNVV-KILLSEVVECIKEVSEATRQRQRELRQKELNADYSWLT--T 72 
Q18653         4 WLfqsegvtrSFDTPSETQS-ArddrKTIGdyadNFLLFDLVMGEVEMAVIRFEIEKEEKEEAERKAERRPDYSWLIsgN 82  Caenorhabditis ...
EFO92143      90 WFfqgdnvarSFDSPSETQS-ArddrKTIGdyadNFLLFDLVIGEVEMAVVRYELDKEMKEEEERKAERRPDYSWLMsgG 168
XP_002634324   4 WLfqsdqvakSFDSPSETQS-ArddrKSIGdfadNILLFDLVIGEIELAVVRFELEKEQKEEEERKAERRPDYSWLVtgG 82 
EDO36221       2 SLsnfglkkrPTEAPYSKPD--------------YILVCETILCELEGQIKSLEDRQQEMEKEEKRKACIADYSWLI--S 65 
EKC25839      24 WK--------SFISESHRPP------EKDT----KVVVVDTIIHELEYHIKELERIAHDKEIDDRRRNTGVDYSWLI--S 83 
XP_006003386  67 RE-SLKPPIAATERRKLEILCSQVQPCHTGTVLCRLREVLaENDALPWEVVYIFKRILKDFLAKTEEEK 134
1_pfamImport  80 AN-RAKKQLSVHEKNRIENACERLKPCEWSKTIDTWKEKI-QNAETRDEIVDHFVCATHETILARKHDP 146
XP_017208112  76 YP-NLLALIPASEHRQLEHLCGRIPPSHSAIVLARLHDLLaHNDIPPWELVSVFKQVLKEFLRRHEDGM 143
XP_002600040  69 TRsRSRYQLSQMDRLELETMCSQVRPEESGDVIVRFRDRL-YPEMSAQEIPLVMRAVIRQVFQRRNPAP 136
XP_002111930  73 NS-FKNDRIPDVERDELEILARKISPDETAQIILTFRDAA-LLETDCKQLPSIMKCTIQTYLWNKYSDE 139
Q18653        83 MN-RARKQLSINEKNRIENACERLKPCEWSKTIDTWKIKT-QNPSTRDQIIENFVIATHETIQSRKHEP 149 Caenorhabditis elegans
EFO92143     169 SR-RFRKQLDAGERNRIENACERLKPCEWSKTIETWKMKT-KNPESRDDIIKLFVAATHDTIQSRKHEP 235
XP_002634324  83 AR-RHRKQLSLQEKNRIENACERLKPCEWSKTIDTWKTRT-QSPTSRDQIIEEFVLATHGTIQARKHEP 149
EDO36221      66 SPeRKSFQIPPAQRLTLEDLAAKVRPEDSSEILSQFRKVLeSQKLVPRDLPQIMQCVIERYLSERKDSD 134
EKC25839      84 TA-PKGFEIPQLQRLELEELCYKIKPEECSRILSLFRDSL-FNDPLPSHLPRIMRSCIIQVIEQRPKEE 150
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