Conserved Protein Domain Family
ASKHA_NBD_HSP70_HSPA12A
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cd11735: ASKHA_NBD_HSP70_HSPA12A 
nucleotide-binding domain (NBD) of heat shock 70 kDa protein 12A (HSPA12A) and similar proteins
HSPA12A is an adapter protein for SORL1, but not SORT1. It delays SORL1 internalization and affects SORL1 subcellular localization. HSPA12A belongs to the heat shock protein 70 (HSP70) family of chaperones that assist in protein folding and assembly, and can direct incompetent "client" proteins towards degradation. Typically, HSP70s have a nucleotide-binding domain (NBD) and a substrate-binding domain (SBD). The nucleotide sits in a deep cleft formed between the two lobes of the NBD. The two subdomains of each lobe change conformation between ATP-bound, ADP-bound, and nucleotide-free states. ATP binding opens up the substrate-binding site; substrate-binding increases the rate of ATP hydrolysis. HSP70 chaperone activity is regulated by various co-chaperones: J-domain proteins and nucleotide exchange factors (NEFs). No co-chaperones have yet been identified for HSPA12A.
Links
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Statistics
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PSSM-Id: 466841
Aligned: 5 rows
Threshold Bit Score: 865.857
Created: 6-Apr-2012
Updated: 27-Apr-2023
Structure
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Aligned Rows:
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Feature 1:putative nucleotide binding site [chemical binding site]
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1             # ####                                                                     
O43301        57 VVVAVDFGTTSSGYAYSFtkePECIHVMRRWEggdpgvsnQKTPTTILLTPerkfHSFGYAARDFYHDLDPneakqWLYL 136 human
OCT71301      54 IVVAIDFGTTSSGYAYSFakePECIHIMRRWEggdpgvsnQKTPTTMLLMPdrkfHSFGFAARDFYHDLDPseskhWLYF 133 African clawed ...
TFK09850      53 VVVAIDFGTTSSGYAYSFtkePECIHVMRRWEggdpgvsnQKTPTTILLTPerkfHSFGYAARDFYHDLDPneskhWLYF 132 big-headed turtle
XP_007907348  56 VVIAIDFGTTSSGYAYSFtrdSESIHIMRRWEggdpgvsnQKTPTTILLTPegtyHSFGYAARDFYHDLDPndskqWLYF 135 elephant shark
TWW77890      94 VVVAIDFGTTSSGYAYAFtkePECIHVMRRWEggdpgvsnQKTPTTILLTPdrkfHSFGYAARDFYHDLDPsesklWLYL 173 sansaifugu

Feature 1                                                                                        
O43301       137 EKFKMKLHttgdltmdtdLTAANGKKVKALEIFAYALQYFKEQALKELSDQAGsefensDVRWVITVPAIWKQPAKQFMR 216 human
OCT71301     134 EKFKMKLHsstdltmeteLTAANGKRVKALEIFAYALQYFKEQALKELSDQAGtemdnsEVRWVITVPAIWKQPAKQFMR 213 African clawed ...
TFK09850     133 EKFKMKLHttgnltmetdLTAANGKKVKALEIFAYALQFFKEQALKELSDQAGsdfensEVRWVITVPAIWKQPAKQFMR 212 big-headed turtle
XP_007907348 136 EKFKMKLHtsssltietdLEAANGKKVKALEIFAFALEFFKDHALQELSDQTGtkfdnaDVRWVITVPAIWKQPAKQFMR 215 elephant shark
TWW77890     174 EKFKMKLHttanlsintdLHAANGKRVKALDIFAYALAFFKEQALKELSDQTGsefdnnDVRWVITVPAIWKMPAKQFMR 253 sansaifugu

Feature 1                             #                                                          
O43301       217 QAAYQAGlaspensEQLIIALEPEAASIYCRKLRLHQMielsskaavngysgsdtvgagftqake--------------- 281 human
OCT71301     214 QAAYKAGmatpenpEQLIIALEPEGASIYCRKLRLHQMidlsskaaingisptdpakdhvrr------------------ 275 African clawed ...
TFK09850     213 QAAYKAGmatpenpEPLIIALEPEAASIYCRKLRLHQMidlsskapvngynasdtvgagftqake--------------- 277 big-headed turtle
XP_007907348 216 HAAYKAAlaspefpEQLIIALEPEAASIYCRKLRLHQMielsgkeavngysptetmgsgithake--------------- 280 elephant shark
TWW77890     254 EAAYKAAlasrdapEQLIIALEPEAASIYCRKLRLHQMvdlgtqtthndlgtndnvgsgmtqvyvrpvyvllgrydvlnl 333 sansaifugu

Feature 1                                                                                        
O43301       282 ----------------------------------------------------------hirrnrqsrtflvenvigeiws 303 human
OCT71301     276 --------------------------------------------------------------nrqsrtflvenvigelws 293 African clawed ...
TFK09850     278 ----------------------------------------------------------hirrnrqsrtflvenvigeiws 299 big-headed turtle
XP_007907348 281 ----------------------------------------------------------ytrrnrqsrtflvenvigeiws 302 elephant shark
TWW77890     334 slaalhipvrlkgrstapehvqgtlqgcvspnnpniqslkdsssllfhswspstvakehvrrnrqsrtflvenvigelws 413 sansaifugu

Feature 1                   # ####                           ##                                  
O43301       304 eleegDKYVVVDSGGGTVDLTVHQirlpeghLKELYKATGGPYGSLGVDYEFEKLLYKIFGEDFieqfkiKRPAAWVDLM 383 human
OCT71301     294 eleegDRYVVVDCGGGTVDLTVHQirlpeghLKELYKASGGPYGSLGVDYEFEKLLCKIFGDDFidtfkvKRPAAWVDLM 373 African clawed ...
TFK09850     300 eleegDRYIVVDSGGGTVDLTVHQirlpeghLKELYKATGGPYGSIGVDYEFEKLLCKIFGEDFieqfkiKRPAAWVDLM 379 big-headed turtle
XP_007907348 303 eleqgDRYLVVDCGGGTVDLTVHEiklpeghLKELYKASGGPYGSIGVDYEFEKLLCKIFGEDFidqfkiKRPAAWVDLM 382 elephant shark
TWW77890     414 eleegDRYVVVDCGGGTVDLTVHQirlpeghLKELYKASGGPYGSLGIDYEFEKLLCKIFGQDFidqfkiKRPAAWVDLM 493 sansaifugu

Feature 1           #  ##  #                                                                     
O43301       384 IAFESRKRAAAPDRTNPLNITLPFsFIDYYKKFRGHSVEHALRKsnvdfvKWSSQGMLRMSPDAMNALFKPTIDSIIEHL 463 human
OCT71301     374 IAFESRKRAAAPDRTNPLNITLPFsFIDYYKKFRGHSVEHALRKsnvdfvKWSSQGMLRMNPDAMNALFKSTIDHIIEHL 453 African clawed ...
TFK09850     380 IAFESRKRAAAPDRTNPLNITLPFsFIDYYKKFRGHSVEHALRKsnvdfvKWSSQGMLRMSPDAMNALFKPTIDQIIQHL 459 big-headed turtle
XP_007907348 383 IAFESRKRAAAPGRINPLNINLPFsFIDYYKKFRGHSVEHALRKssvnfvKWSSQGMLRMNPDAMNALFKPTVDHIVQHL 462 elephant shark
TWW77890     494 IAFESRKRAAAPDRTNPLNINLPFsFIDYYKKFRGHSVEHALRKsnvdfvKWSSQGMLRMSPDAMNSLFKPTIDHIIQHL 573 sansaifugu

Feature 1                          ### ##                       #            
O43301       464 RDLFqkpevsTVKFLFLVGGFAEAPLLQQAVQAAFGdqCRIIIPQDVGLTILKGAVLFGL 523 human
OCT71301     454 TNLFqkpevtGVKFLFLVGGFAESPLLQQAVQQAFGdqCRVIIPHDVGLTILKGAVLFGL 513 African clawed frog
TFK09850     460 SDLFekpevtNVKFLFLVGGFAEAPLLQQAVQNAFGskCRIIIPQDVGLTILKGAVLFGL 519 big-headed turtle
XP_007907348 463 SDLFqkpevsGIKFLFLVGGFAESPLLQQAVQSSLSetCRVIIPHDVGLTILKGAVLFGL 522 elephant shark
TWW77890     574 TELFekpevgEIKFLFLVGGFAESPLLQQAVQNMLQgrSRVIIPHDVGLTILKGAVLFGL 633 sansaifugu

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