Conserved Protein Domain Family
SLC6sbd_NET
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cd11512: SLC6sbd_NET 
Na(+)- and Cl(-)-dependent norepinephrine transporter NET; solute-binding domain
NET (also called NAT1, NET1), is a transmembrane transporter that transports the neurotransmitter norepinephrine from synaptic spaces into presynaptic neurons. Human NET is encoded by the SLC6A2 gene. NET is expressed in brain, peripheral nervous system, adrenal gland, and placenta. NET may play a role in diseases or disorders including depression, orthostatic intolerance, anorexia nervosa, cardiovascular diseases, alcoholism, and attention-deficit hyperactivity disorder. This subgroup belongs to the solute carrier 6 (SLC6) transporter family.
Links
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Statistics
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PSSM-Id: 212081
Aligned: 3 rows
Threshold Bit Score: 1105.79
Created: 20-Jul-2011
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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  next features
Feature 1: putative glycosylation site [posttranslational modification site], 1 residue position
Conserved feature residue pattern:NClick to see conserved feature residue pattern help
Evidence:
  • Comment:based on site-directed mutagenesis of human NET
  • Citation:PMID 8764591
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                     
AAB67676   69 REHWGKKIDFLLSVVGFSVDLANVWRFPYLCYKNGGGAFLIPYTLFLIIAGMPLFYMELALGQYNREGAATVWKICPCFK 148 bullfrog
P23975     56 RETWGKKIDFLLSVVGFAVDLANVWRFPYLCYKNGGGAFLIPYTLFLIIAGMPLFYMELALGQYNREGAATVWKICPFFK 135 human
NP_990047  74 RETWGKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLIPYILFLIIAGMPLFYMELALGQYNREGAATVWKICPVFK 153 chicken

Feature 1                                                     #                               
AAB67676  149 GVGYTVILIALYVGFYYNVIIAWSLYYLASSFTSELPWTTCGNVWNTPNCTDPtLLNASFFGNGTKYSKYKLTPATQFYE 228 bullfrog
P23975    136 GVGYAVILIALYVGFYYNVIIAWSLYYLFSSFTLNLPWTDCGHTWNSPNCTDPkLLNGSVLGNHTKYSKYKFTPAAEFYE 215 human
NP_990047 154 GVGYAVILIALYVGFYYNVIIAWSLYYLFSSFTFELPWTNCDNSWNSPNCTDPkLFNASVLGNGTKYSKYKLTPAAEFYE 233 chicken

Feature 1                                                                                     
AAB67676  229 REVLHLHESAGIHDLGLPRWQLTLCLFAVLIVLFFSLWKGVKTSGKVVWITATLPYVVLFVLLIRGVTLPGSFKGISAYL 308 bullfrog
P23975    216 RGVLHLHESSGIHDIGLPQWQLLLCLMVVVIVLYFSLWKGVKTSGKVVWITATLPYFVLFVLLVHGVTLPGASNGINAYL 295 human
NP_990047 234 RGVLHLHESRGIHDLGLPRWQLSLCLLVVVIILFFSLWKGVKTSGKVVWITATLPYVVLFVLLIHGITLPGAYNGINAYL 313 chicken

Feature 1                                                                                     
AAB67676  309 HIDFKRLKEPGVWIDAATQIFYSLGAGFGVLIAFASYNKFDNNCYRDALLTSTINCVTSFISGFAIFSILGYMAQknnVK 388 bullfrog
P23975    296 HIDFYRLKEATVWIDAATQIFFSLGAGFGVLIAFASYNKFDNNCYRDALLTSSINCITSFVSGFAIFSILGYMAHehkVN 375 human
NP_990047 314 HIDFRRLKEATVWIDAATQIFYSLGAGFGVLIAFASYNKFDNNCYRDALLTSTINCVTSFISGFAIFSILGYMAHehkVK 393 chicken

Feature 1                                                                                     
AAB67676  389 IEDVATEGPGLVFIIYPEAISTLrGSTFWAVVFFIMLLTLGIDSAMGGMEAVITGMADDFsIVKKHRKAFTFAVAFITFL 468 bullfrog
P23975    376 IEDVATEGAGLVFILYPEAISTLsGSTFWAVVFFVMLLALGLDSSMGGMEAVITGLADDFqVLKRHRKLFTFGVTFSTFL 455 human
NP_990047 394 IEDVATEGAGLVFILYPEAISTLsGSTFWAVVFFIMLLTLGIDSSMGGMEAVITGLADDFhILKQHRKLFTFGVSFGTFL 473 chicken

Feature 1                                                                                     
AAB67676  469 LALLCITNGGIYVVTLLDTFAAGTSILFAVLIEAVGVSWFYGVDRFSDDIYRMLGFRPGLYWRLCWKFVSPAFLLFVVIT 548 bullfrog
P23975    456 LALFCITKGGIYVLTLLDTFAAGTSILFAVLMEAIGVSWFYGVDRFSNDIQQMMGFRPGLYWRLCWKFVSPAFLLFVVVV 535 human
NP_990047 474 LALFCITNGGIYVLTLLDTFAAGTSILFAVLMEAIGVSWFYGVDRFSEDIQQMMGFKPGLYWRLCWKFVSPAFLLFVVIV 553 chicken

Feature 1                                                                                     
AAB67676  549 SIVTHSPLSYDDYNFPPWANRTGWAIALSSMLLVPIYSVYKFFTVPGTFEQKLGYCITPENEYYLVQQGDIRQFKLKHWL 628 bullfrog
P23975    536 SIINFKPLTYDDYIFPPWANWVGWGIALSSMVLVPIYVIYKFLSTQGSLWERLAYGITPENEHHLVAQRDIRQFQLQHWL 615 human
NP_990047 554 SIINFKPLTYDDYTFPFWANRIGWGIALSSMILVPAYVIYKFMNVRGTFKERLAYCITPENEHQLVAQGNVRQFKLQHWL 633 chicken

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