4NQY


Conserved Protein Domain Family
LeuC

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COG0065: LeuC 
Homoaconitase/3-isopropylmalate dehydratase large subunit [Amino acid transport and metabolism]
Homoaconitase/3-isopropylmalate dehydratase large subunit is part of the Pathway/BioSystem: Isoleucine, leucine, valine biosynthesis
Statistics
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PSSM-Id: 439835
Aligned: 783 rows
Threshold Bit Score: 379.375
Created: 9-Feb-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4NQY_A        20 MGMTIVEKILAKASgkkEvSPGDIVMANIDVAMVHDITGPLTVNTLKEYGiEKVWNPEKIVILFDHQVPADSIKAAENHI 99 
WP_012176572   1 MGKTIAQKIFDAHSv--DqPFGEVHVIRLDGVFCHEITTPTAICDLMEKNkDRVFDPSKIKAVIDHVTPAKDSKTAAQGK 78 
WP_015903691   1 MGKTIAEKIFDAHTv--DkPGGDIVVINLDAVFCHEITTPIAINDLVARGkDRVFDRSKIKAVIDHVTPAKDSKTALQGK 78 
WP_013162767   1 MGQTIVEKIFAAHRr--DtPTPENIILDLDVVMCHEITTPIAVTDLEARGmDRVFDPDKIKVVIDHVTPAKDSKTATQGK 78 
WP_013505036   1 MGKTVAQKIFDAHLr--DePFPGTKVLSLDMVFCHEITTPIAIDDLVRLGkDRVFDPNKIKAVIDHVTPAKDSKTAQQGK 78 
WP_014185981   1 MGKTIAEKIFDAHRv--DmPFPDTHVLKLDRVFCHEITTPIAITDLMARGmDRVYDPTKIKAVIDHVTPAKDSKTAEQGK 78 
WP_014959223   1 MGKTIAEKIFDAHLv--DePFGDVSVLKLDRVFCHEITTPTAIQDLVARGkDRVFDPEKIKAVIDHVTPAKDSKTAMQGK 78 
WP_015405045   1 MGKTIAQKIFDAHLr--DtPTPENMVLDLDVVLCHEITTPIAIMDLMEKGmDRVFDPNKIKAVIDHVTPAKDSKTAAQGK 78 
WP_040200805   1 MGQTIAEKIFSTHLr--DePFPGTYVLDLDRVLCHEITTPVAIADLQWRGkDRVFDPDCIKAVIDHVTPAKDSKTATQGK 78 
WP_106052588   1 MGKTLAQKIFDAHTv--DtPAPGVRVLSLDRVFCHEITTPIAINDLVAIGkDRVFDPTKIKAVIDHVTPAKDSKTAEQGK 78 
4NQY_A       100 LMRKFVKEQGIKyFYDI-ReGVCHQVLPEKGHVAPGEVVVGADSHTCTHGAFGAFATGIGSTDMAHVFATGKLWFKVPET 178
WP_012176572  79 ILRQWARRHGIDgFFDIgRnGVCHALFPEQGFVRPGHTIIMGDSHTCTYGAFGAFAAGVGTTDLEVGILKGVCALNYPST 158
WP_015903691  79 TLRDWAKRHEIKdFFDIgRnGVCHAIFPEKGFVRPGYTIIMGDSHTCTHGAFGAFAAGVGTTDLEVGILKGVCAFKKPFS 158
WP_013162767  79 ILRDWARRQNIRdFFDIgRnGVCHALFPEKGFIRPGYTVIMGDSHTCTHGAFGAFAAGVGTTDLEVGILKGVCSFRLPRT 158
WP_013505036  79 VLRDWARRHSIKdFFDIgRnGVCHAIFPEKGFVRPGYTIIMGDSHTCTHGAFGAFAAGVGTTDLEVGILKGVCAFRQPKT 158
WP_014185981  79 ILRDWAKRHGIKdFFDIgRnGVCHAIFPEKGFVRPGYTVIMGDSHTCTHGAFGAFAAGVGTTDLEVGILKGVCAFHFPKT 158
WP_014959223  79 ILRDWAKRHKIKdFFDIgHnGVCHAIFPEKGFARPGFTIIMGDSHTCTHGAFGAFAAGVGTTDLEVGILKGVCTFKKPET 158
WP_015405045  79 IMREWAKRQNIKdFFDVgEnGVCHALFPEKGFIRPGYTVIMGDSHTCTHGAFGAFAAGVGTTDLEVGILKGVCTFRAPVS 158
WP_040200805  79 MLREWARRHEIKdFFDVgRnGVCHALFPEKGFIRPGFTVIMGDSHTCTHGAFGAFAAGVGTTDLEVGILKGVCAFRKPNT 158
WP_106052588  79 TMREWAKRQGIKdFFDIgEnGVCHAIFPEKGFVRPGFTVIMGDSHTCTHGAFGAFAAGVGTTDLEVGILKGVCTMREPAT 158
4NQY_A       179 IYFNITGDLQPYVTSKDVILSIIGEVGVDGATYKACQFGGETVKKMSIASRMTMTNMAIEMGGKTGIIEPDEKTIQYVKE 258
WP_012176572 159 IKVVLNGKLSPGVYAKDVILAVIAELGVNGATNRVIEFTGPCVDAMSMEARMTLCNMAIEAGGTCGICYPDKTTVAYLWE 238
WP_015903691 159 MKVEISGTLGAGVYAKDVILSIIKTIGVNGATDRVMEFSGPVVDHMTMEERMTLCNMAVEAGATSGICPPDRVTVDYLWR 238
WP_013162767 159 IKVEINGKLPAGVYAKDVILYIIKTITVNGATDRVLEFAGPVVDAMSMEARMTLCNMAIEAGATCGICPPDKTTAEYLWP 238
WP_013505036 159 LRINVNGTLPKGVYAKDVILHIIGTISVNGATDMVIEFGGNVVENLSMESRMTLCNMAIEAGGTSGICAPDMTTVEYLWP 238
WP_014185981 159 IKIVLKGTLQPGVYAKDLILFIIKELTVNGATNMVIEFTGPVVDAMSMESRMTLCNMAIEAGGTCGICYPDMTTVNYLWD 238
WP_014959223 159 YKIEIVGTLQNGVYAKDIILKVIQELGVNGATNMVIEFRGNIVDEMNMDQRMTLSNMAVEAGATSGICLPDMTTVEYLWD 238
WP_015405045 159 MKVSISGILQNGVSAKDVILAVIKKLTVNGATDKVIEFTGPLVDSMNMSARMTLCNMAVEAGATSGLCYPDRVTAEYLWQ 238
WP_040200805 159 IRVNLEGSLAQGVYAKDVILYVIGQLGVNGATDRVIEFRGSVVDGMSMEARMTLCNMAIEAGGTSGICLPDMTTVNYLWP 238
WP_106052588 159 IKVVLNGKLRSGVFAKDVILAVIRLLTVNGATDKVIEFTGPAVDAMGMDSRMTLCNMAIEAGGTCGVCYPDMVTVDFLWP 238
4NQY_A       259 ----------AMKkhgteRPFEVIKGDEDAEFAEVYEIEADKIEPVFACPHNVDNVKQAREVAGKPIDQVFIGSCTNGRL 328
WP_012176572 239 fikgeypsrqAAL-----KAFKKLVSDPDADYDRVLEMDISDLSPRVTYGYKPDCVKPVAEMEGTPIDQVYIGSCTNGRL 313
WP_015903691 239 fikddysskdAAF-----EAFMAFAPDADAVYADTLKIDVTTLSPQVTFGFKPDQVRSVAEMAGTPIDQVYIGSCTNGRI 313
WP_013162767 239 fiqndyatvdQAA-----ADFRQWHSDPDAAYEQVLEFDVSTLAPQVTFGFKPDEVKDITAMEGVPVDQIYIGSCTNGRI 313
WP_013505036 239 fikddypskeAAL-----EDYKQWQPDADAEYERVLEIDASSLEPMCTYGYKPDCVKPVSQMTDSKIDQVYIGSCTNGRI 313
WP_014185981 239 fikdefstkeEAL-----QEYSKWTSDADAAYEKVYEYDVTDLGPMATFGNKPDQVKTVAEMSGTAIDQVYIGSCTNGRI 313
WP_014959223 239 fikdehaskqEAL-----ETFSTFNSDEDAVYANQKTIDVSDLEPLTTFGYKPDNVKPVSQMKGTKIDQVYIGSCTNGRL 313
WP_015405045 239 fikddyttidAAV-----AKFEKWHSDADAEYASVIELDVSELEPQVTYGYKPDHVKNIREMEGTPVDQIYIGSCTNGRI 313
WP_040200805 239 fissdypdkeAAL-----KDFSRWHSDADAEYEKVLDFDVCDLEPQVTFDYKPDCVKSVGEMAGTPVDQVYIGTCTNGRI 313
WP_106052588 239 fikddfaskeAAL-----AEYSKWLPDADAVYDKVVAMDVSELEPMVTFGYKPDQVKTVREMEGTPVNQIYIGSCTNGRL 313
4NQY_A       329 EDLRMAIKIIEKHgGIADDVRVVVTPASREEYLKALKEGIIEKFLKYGCVVTNPSCSACMGSLYGVLGPGEVCVSTSNRN 408
WP_012176572 314 EDLRVAAKVLKGK-KVHPSVRGIVSPATPTVFQAALEEGLIATFMAAGFCVTNPTCGACLGMSNGVLAPGEVCLSTTNRN 392
WP_015903691 314 EDLRIAAQILKGK-TISPDVRAIVSPATPEIFSMALEEGLIKTFMDAGFCVTNPTCGACLGMSNGILAPGEACASTTNRN 392
WP_013162767 314 EDLREAAKVLKGR-RIADQVRGILSPATPKVYNQAMEEGLLKIFQEAGFCVTNPTCGACLGMSNGVLAEGEVCASTTNRN 392
WP_013505036 314 EDLREAAAVLKGK-TIADSVRGILSPATPDIFKQANHEGLIDIFLEAGFCVTNPTCGACLGMSNGVLAEGEACASTTNRN 392
WP_014185981 314 EDLRIAASILKDK-KISDDVRAIVSPATPAIFNMALKEGLIEIFQNAGFCVTNPTCGACLGMSNGVLASGEVCASTTNRN 392
WP_014959223 314 EDLRIAAKVLEGH-TINENVRGIVSPATPKIFSQALEEGIIKIFMESGFCVTNPTCGACLGMSNGVLADGEVAAATTNRN 392
WP_015405045 314 EDLRQAAAILKGK-RLASGVRGIVTPATPGIYSQALEEGIIKIFMDAGFCVLNPTCGACLGMSSGVLAEGEVCASTTNRN 392
WP_040200805 314 EDLRVAAEILKGR-KLADTVRGIVSPATPKIFQDALAEGIIQVFMDAGFCVTNPTCGACLGMSNGVLAEGEVCASTSNRN 392
WP_106052588 314 EDLRIAAGILKGK-KISENVRAIVSPATPKIYREALKEGLIEIFMEAGFCVTNPTCGACLGMSNGVLANGESCASTTNRN 392
4NQY_A       409 FRGRQGSlEAEIYLASPITAAACAVKGELVDPRDL 443
WP_012176572 393 FNGRMGK-GGMVHLASPATAAAGAIAGCITNSKLY 426
WP_015903691 393 FNGRMGK-GGMVHLMSPATAAASAIAGKIANSEIF 426
WP_013162767 393 FNGRMGK-GGIVHLMSPLSAAAAAVAGKITDPRPL 426
WP_013505036 393 FNGRMGK-GGMVHLMSPAAAAAAAITGHITDPRKY 426
WP_014185981 393 FNGRMGK-GGTVHLMSPATAAASAIEGKITNSQLY 426
WP_014959223 393 FNGRMGK-GGMVHLMSPATAAASAITGEISNSSLF 426
WP_015405045 393 FNGRMGK-GGMVHLMSPASAAAAAITGTISDPRQF 426
WP_040200805 393 FNGRMGK-GGMVHLMSPSTAAATAVKGVITDARRI 426
WP_106052588 393 FNGRMGK-GGMVHLMSPATAAATAIAGVITNSPFF 426
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